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91.
Eight pigeons responded in a concurrent-chains procedure in which terminal-link schedules changed pseudorandomly across sessions. Pairs of terminal-link delays either summed to 15 s or to 45 s. Across sessions, the location of the shorter terminal link changed according to a pseudorandom binary sequence. On some terminal links, food was withheld to obtain start and stop times, measures of temporal control. Log initial-link response ratios stabilized within the first half of each session. Log response ratio was a monotonically-increasing but nonlinear function of programmed log terminal-link immediacy ratio. There was an effect of absolute terminal-link duration on log response ratio: For most subjects, preference for the relatively shorter terminal-link delay was stronger when absolute delays were long than when absolute delays were short. Polynomial regressions and model comparison showed that differences in degree of nonlinearity, not in sensitivity to log immediacy ratio, produced this effect. Temporal control of stop times was timescale invariant with scalar variability, but temporal control of start times was not consistent across subjects or terminal-link durations. 相似文献
92.
探讨不同地塞米松给药方法对芬太尼咳嗽反射抑制的效果。选择200例全麻患者分为四组,按不同方法静脉注射地塞米松。诱导时芬太尼用量为5Mg·kg。观察各组患者出现咳嗽的例数和强度变化以及心率(HR)、平均动脉血压(MAP)、脉搏氧饱和度(SpO2)、脑电双频谱指数(BIS)的变化。结果显示,提前15min静注地塞米松组(Ⅰ组)咳嗽发生率为8%,与其他组有显著性差异。静注芬太尼2min时段Ⅰ组的HR、MAP和BIS与其他组相比有显著性差异。组内发生咳嗽反射患者HR、MAP明显升高,BIS值也有所回升。认为预先15min静脉注射地塞米松更有效降低麻醉诱导期间芬太尼所致咳嗽反射的发生。 相似文献
93.
条件反射性免疫抑制激活过程中下丘脑核团c-fos的表达 总被引:1,自引:0,他引:1
利用经典条件反射性免疫抑制的动物模型,以糖精水为条件刺激(CS),免疫抑制剂-环磷酰胺为非条件刺激 (UCS),观测两次CS-UCS结合训练后,再次条件刺激诱发条件反射性免疫抑制作用的动态改变,获得条件反射性免疫抑制和味觉厌恶性条件反射各自保持的情况,并在此基础上,采用c-fos免疫组化技术, 进一步观察再次条件刺激诱发条件反射性免疫抑制反应时大鼠下丘脑各核团内FOS蛋白的表达情况。结果表明,条件反射性免疫抑制作用在训练后第5天较强,第30天基本消失,而味觉厌恶性条件反射始终稳定保持到第30天。进一步研究显示出,下丘脑室旁核FOS蛋白表达在第5天非常密集,而第30天几乎没有表达,与细胞免疫功能改变在时程和趋势上具有一致性。通过FOS蛋白表达时程差异比较,提示下丘脑室旁核可能是CNS内介导CS诱导的免疫抑制效应的重要核团。 相似文献
94.
The most reproducible and ubiquitous interictal abnormality of the migraineurs’ brain is lack of habituation in neuronal information processing. The underlying mechanisms are uncertain. Increased neuronal excitability, decreased inhibition or decreased pre-activation levels have all been proposed as possible culprits.The present review summarizes the available data on habituation in migraine patients obtained with different methodological approaches. We will discuss the change of habituation level over the migraine cycle and we will show that these data congruently indicate that the sensory cortices of migraineurs react excessively to repetitive, but not to a small series of stimuli.Although the precise cellular and molecular mechanisms of this hyper-responsivity must still be determined, we will describe experimental data suggesting that a dysrhythmic thalamo-cortical activity due to inadequate monoaminergic control might be a plausible explanation. 相似文献
95.
96.
OBSERVING RESPONSES AND SERIAL STIMULI: SEARCHING FOR THE REINFORCING PROPERTIES OF THE S−
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Rogelio Escobar Carlos A. Bruner 《Journal of the experimental analysis of behavior》2009,92(2):215-231
The control exerted by a stimulus associated with an extinction component (S−) on observing responses was determined as a function of its temporal relation with the onset of the reinforcement component. Lever pressing by rats was reinforced on a mixed random-interval extinction schedule. Each press on a second lever produced stimuli associated with the component of the schedule in effect. In Experiment 1 a response-dependent clock procedure that incorporated different stimuli associated with an extinction component of a variable duration was used. When a single S− was presented throughout the extinction component, the rate of observing remained relatively constant across this component. In the response-dependent clock procedure, observing responses increased from the beginning to the end of the extinction component. This result was replicated in Experiment 2, using a similar clock procedure but keeping the number of stimuli per extinction component constant. We conclude that the S− can function as a conditioned reinforcer, a neutral stimulus or as an aversive stimulus, depending on its temporal location within the extinction component. 相似文献
97.
Grace RC 《Journal of the experimental analysis of behavior》1994,61(1):113-129
An extension of the generalized matching law incorporating context effects on terminal-link sensitivity is proposed as a quantitative model of behavior under concurrent chains. The contextual choice model makes many of the same qualitative predictions as the delay-reduction hypothesis, and assumes that the crucial contextual variable in concurrent chains is the ratio of average times spent, per reinforcement, in the terminal and initial links; this ratio controls differential effectiveness of terminal-link stimuli as conditioned reinforcers. Ninety-two concurrent-chains data sets from 19 published studies were fitted to the model. Averaged across all studies, the model accounted for 90% of the variance in pigeons' relative initial-link responding. The model therefore demonstrates that a matching law analysis of concurrent chains—the assumption that relative initial-link responding equals relative terminal-link value—remains quantitatively viable. Because the model reduces to the generalized matching law when terminal-link duration is zero, it provides a quantitative integration of concurrent schedules and concurrent chains. 相似文献
98.
Choice between reliable and unreliable reinforcement alternatives revisited: Preference for unreliable reinforcement 总被引:1,自引:1,他引:0
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Pigeons' choices between a reliable alternative that always provided food after a delay (i.e., 100% reinforcement) and an unreliable one that provided food or blackout equally often after a delay (i.e., 50% reinforcement) was studied using a discrete-trials concurrent-chains procedure modified to prevent choice between alternatives following a blackout outcome. Initial links were fixed-ratio 1 schedules, and terminal links were fixed-time schedules. Stimuli presented during the terminal-link delays were correlated with the food and blackout outcomes. In Experiment 1, terminal-link durations were varied. With short terminal links (i.e., 10 s), 6 of 8 subjects showed strong preference for the 50% side. As terminal-link duration increased to 30 s, preference, regardless of direction, became less extreme. In Experiment 2, the side-key location of the 50% and 100% alternatives was reversed for 3 subjects. Preference for the 50% alternative reoccurred following the key reversal. When a 5-s separation was subsequently interposed between the initial and terminal links for both alternatives, all birds reversed to a preference for the 100% side. In general, the strong preference for the 50% side was qualitatively consistent with the expectation that the procedure enhanced the conditioned-reinforcement effectiveness of the food-associated terminal-link stimulus on the 50% side. Implications of the results for various accounts of choice of the 50% alternative are discussed. 相似文献
99.
Pigeons were trained on simultaneous red-green discrimination procedures with delayed reward and sequences of stimuli during the delay. In Experiment 1, three stimuli appeared during the 60-second intervals between the correct responses and reward, and the incorrect responses and nonreward. The stimulus that immediately followed a correct response also preceded nonreward, and the stimulus that followed an incorrect response preceded reward. These stimuli were 10 or .33 second in duration for different groups. Stimuli during the remainder of the delay interval differed following correct and incorrect responses. Group 10 initially persisted in the nonrewarded choice, but shifted to a preponderance of rewarded responses after further training. Group .33 rapidly acquired the correct response. Similar results were obtained in Experiment 2 where delay intervals consisted of opposite sequences of two stimuli of equal duration and total delays were 6, 20, or 60 seconds. Early in training, generalization of differential conditioned-reinforcing properties from the conditions preceding reward and nonreward to postchoice conditions had a greater effect relative to backchaining than it did later. It was concluded that delayed-reward learning is best analyzed in terms of the conditioned-reinforcing value of the patterns of cues that follow immediately after rewarded and nonrewarded responses. 相似文献
100.
The relative immediacy of reinforcement in concurrent-chain schedules was varied while the relative reduction in the overall average time to reinforcement associated with terminal-link entry was held constant. For each of four pigeons, choice did not vary with relative immediacy of reinforcement. Subsequently, choice by the same subjects was shown to be sensitive to relative reduction in average time to reinforcement. 相似文献