Le vaccin,un médicament devenu l’arme absolue promise contre la COVID-19 : une réglementation adaptée ?

As the first vaccines against COVID-19 arrive on the market, the question of the safety of these products arises in the public debate. The major concern is about the possible occurrence of adverse effects, particularly in the context of the use of novel pharmaceutical technologies such as mRNA. It is important to remind both patients and professionals that a vaccine is not only a medicinal product in its own right, but also a special medicinal product: biological and immunological. As a result, its supervision is draconian, and despite the urgency, no requirements have been lowered. The speed of marketing is the result both of adapted clinical trials and optimized evaluation procedures.     

γ节律神经振荡：反映自闭症多感觉整合失调的一项重要生物指标

多感觉整合是对不同感官信息进行选择、联系、统一乃至解释的加工过程, 它需要神经系统不同功能区域的共同投入与相互协调, 以实现多种感觉信息的时间捆绑以及全局性的预测编码。而γ神经振荡因具有反映神经皮层兴奋/抑制的平衡状况, 实现多感官信息的时间同步, 以及通过跨频耦合实现全局性预测编码的特点, 在多感觉整合的加工过程中发挥着重要作用。相比正常个体, 自闭症患者神经系统中的GABA中间神经元存在结构与功能异常, 导致γ神经振荡紊乱, 由此破坏了正常的时间同步以及预测编码加工, 并最终引发多感觉整合失调。基于上述因果关联, 未来研究可结合无创可逆性干预技术, 以γ节律神经振荡为生物反馈指标, 形成科学系统化的临床干预治疗方案。     

创造力产生过程中的神经振荡机制

创造力究竟是怎么产生的, 目前尚未得出一致的结论。神经电生理技术因其高时间分辨率, 可以准确地揭示创造力产生进程中的神经振荡机制, 从而帮助人们更深刻地理解创造力的本质。近年来的研究发现, 单节律alpha神经振荡会随着创造力的增加而增强, 这反映了创造力产生过程中的内部信息加工需求增加、自上而下的抑制控制增强。同时, 多频段神经振荡交叉节律耦合体现了创造性产生过程中额叶、颞叶和顶叶等多脑区之间信息交流的动态变化。未来研究应该以整合理论框架为基础, 结合多层次多方法的研究工具, 引进更生态化的数理计算方法, 并利用计算神经科学建模来预测个体创造力发展趋势, 从而全面深刻地认识创造力的本质。     

中国人限制性饮食和食物渴求的认知神经机制

物质丰富的时代, 如何抵御美味食物线索带来的食物渴求, 并限制饮食从而保持健康成为人们关注的重要话题之一。近年来, 国内学者为了探讨节食成功的原因, 创建中国食物图片库, 考察限制性饮食的认知神经机制, 以及成功和失败限制性饮食者的脑机制差异; 开展了特质食物渴求及中国特色的辣食渴求的认知神经研究。对推进饮食行为研究的理论发展, 也为肥胖、饮食失调等健康干预工作提供重要支持。     

解读不显著结果：基于500个实证研究的量化分析

不显著结果(如, p > 0.05)在心理学研究中十分常见, 且容易被误解为接受零假设的证据, 并可能导致分组匹配研究的错误推断或者忽视被小样本的不显著结果掩盖的真实效应。但国内目前尚无实证研究对不显著结果的普遍性及其解读进行调查。本研究调查500篇中文心理学实证研究, 统计其摘要中出现与不显著结果相关的阴性陈述的频率, 判断并统计基于阴性陈述的推断准确性, 并使用贝叶斯因子对不显著结果中包含t值的研究进行重新评估。结果表明, 36%的摘要提及不显著结果, 共包含236个阴性陈述。其中, 41%的阴性陈述对不显著结果的解读出现偏差(如, 解读为支持了零假设)。对包含t值的研究进行贝叶斯因子分析, 结果显示仅有5.1%的不显著结果可以提供强证据支持零假设(BF₀₁ > 10)。与先前对国际心理学期刊的调查结果相比(32%的摘要包含阴性陈述; 72%的阴性陈述对不显著结果的解读错误), 中文心理学期刊中报告不显著结果的比例更高, 且对不显著结果解读错误的比例更低。但国内研究者仍需进一步加强对不显著结果的认识, 推广适于评估不显著结果的统计方法。     

Evolution and the nonlegal equivalent of aggressive criminal behavior

Within the framework of modern evolutionary theory, arguments are reviewed that the nonlegal equivalent of aggressive criminal behavior may have evolved by natural selection among mammals, particularly primates, as part of their overall approach to reproduction. If so, the commission of aggressive crimes (or their nonlegal equivalent) by humans, and even efforts to prevent fellow social group members from being victimized by aggressive crimes, may also be partially explainable in natural selection terms. The plausibility of this deduction was explored, first, by specifying the three elements that a human act must have to be regarded as an aggressive crime. Summarily, these were that (1) injury to a victim must be a likely result of the act, (2) the act must be intended, and (3) the act must elicit negative responses from those witnessing it. The primate behavior literature was examined for evidence that some behavior of nonhumans met all three conditions. Affirmative results were obtained. Therefore, while further research is in order, human aggressive criminal behavior, as well as human efforts to control it, seem to have close parallels in other primates. This would be consistent with the notion that aggressive criminal behavior (along with its condemnation by fellow group members) is part of a social system produced and sustained by natural selection.     

Generating interior search directions for multiobjective linear programming

A new multiobjective linear programming (MOLP) algorithm is presented. The algorithm uses a variant of Karmarkar's interior-point algorithm known as the affine-scaling primal algorithm. Using this single-objective algorithm, interior search directions are generated and used to provide an approximation to the gradient of the (implicitly known) utility function. The approximation is guided by assessing locally relevant preference information for the various interior directions through interaction with a decision maker (DM). The resulting algorithm is an interactive approach that makes its progress towards the solution through the interior of the constraints polytope.     

Some subordinates are more equal than others: Play fihgting amongst adult subordinate male rats

Adult male rats living together form dominance relationships, with one dominant and the remainder adopting subordinate roles. In previous studies, it was shown that in adult male pairs, the subordinate rat initiates more playful contacts and retains a more juvenile response to the playful contacts by the dominant. In this experiment, triads were used to examine the play between subordinate males. The subordinates directed fewer playful contacts to each other than to the dominant rat, and there was a symmetrical play relationship between the subordinates. After the dominant was removed from the colony, one subordinate became the dominant. Playful interactions amongst these pairs increased, with the subordiante intiating more playful contacts than the dominant. Furthermore, from a similarly low frequency of juvenile-type response to playful contact to each other when in triads, the subordinate in the dyads increased its frequency of juvenile responses to the dominant partner. This supports the hypothesis that the playful behavior of subordinate male rats towards the dominant is an adaptive response, playful behavior of subordinate male rats towards the dominant is an adaptive response, serving a “friendship maintenance” function. Finally, when in triads, one subordinate was more playful with the dominant than the other subordinate. It was the least playful subordinate that was the most likely to become the dominant. This sugests that within a colony, not all subordinates are the same. © 1993 Wiley-Liss, Inc.     

Misunderstandings and omissions in textbook accounts of effect sizes

There have been frequent attempts in psychology to reduce the reliance on null hypothesis significance testing (NHST) as the criterion for establishing the importance of results. Many authorities now recommend the reporting of effect sizes (ESs) as a supplement or alternative to NHST. However, there is extensive specialist literature highlighting problems associated with the use and interpretation of ESs. A review of the coverage of ESs in over 100 textbooks on statistical analysis in behavioural science revealed widespread neglect of ESs and the relevant critical issues that have widespread coverage in the more specialist literature. For example, many textbooks claim that ESs should be interpreted as a simple measure of the practical real-world importance of a result despite the fact that ESs are profoundly influenced by features of design and analysis strategy. We seek to highlight areas of misunderstanding about ESs found in the pedagogical literature in the light of the more specialist literature and make recommendations to researchers for the appropriate use and interpretation of ESs. This is critical as statistics textbooks have a crucial role in the education of researchers.     

Aging Affects the Ability to Process the Optic Flow Stimulations: A Functional Near-Infrared Spectrometry Study

Abstract

Optic flow (OF) has been utilized to investigate the sensory integration of visual stimuli during postural control. It is little known how the OF speed affects the aging brain during the sensory integration process of postural control. This study was to examine the effect of OF speeds on the brain activation using functional near-infrared spectroscopy (fNIRS) and postural sway between younger and older adults. Eleven healthy younger adults (5M/6F, age 22?±?1-year-old) and ten healthy older adults (4M/6F, age 71?±?5-year-old) participated in this study. A virtual reality headset was used to provide the OF stimulus at different speeds. A forceplate was used to record the center-of-pressure to compute the amplitude of postural sway (peak-to-peak). Compared with younger adults, older adults showed significantly increased activation in the OF speed of 10?m/s and decreased activation in the OF speed of 20?m/s in the left dorsolateral prefrontal cortex. Older adults also showed decreased activation in the left temporoparietal region (VEST) in the OF speed of 20?m/s. A significant difference in peak-to-peak was found between groups. Our results indicated that age might be associated with the ability to process fast OF stimulation.