肿瘤分子生物学行为与其影像表现关系的探讨

肿瘤基因表达与其影像表现有一定的相关性,为我们用无创的影像学方法显示肿瘤的生物学特征提供了可能。探寻肿瘤分子生物学特性与其影像表现的内在联系,以期对肿瘤浸润和转移做出正确的诊断,从而为临床选择治疗方案、判断疗效和评估预后等提供更多、更有价值的信息。     

BEAUTY IN THE LIVING WORLD

Almost all admit that there is beauty in the natural world. Many suspect that such beauty is more than an adornment of nature. Few in our contemporary world suggest that this beauty is an empirical principle of the natural world itself and instead relegate beauty to the eye and mind of the beholder. Guided by theological and scientific insight, the authors propose that such exclusion is no longer tenable, at least in the data of modern biology and in our view of the natural world in general. More important, we believe an empirical aesthetics exists that can help guide experimental design and development of computational models in biology. Moreover, because theology and science can both contribute toward and equally profit from such an aesthetics, we propose that this empirical aesthetics provides the foundation for a living synergy between theology and science.     

Is Biosphere Doing Theology?

Three theories about evolution are presently under discussion: the genocentric theory, the organismocentric theory, and the biospherocentric theory. A brief discussion of the three theories is presented. These theories have different implications for theology. The genocentric theory is related to the Darwinian interpretation and, for theology, means the end of an apologetic vision of natural science and for this reason the end of natural theology. The organismo-centric theory is mainly related to events of autoorganization and follows the path of the geometrical harmony of nature. But it is far different from the apologetic interpretation of natural theology which cannot be restored. The biospherocentric theory, on the contrary, contains many fruitful perspectives. This theory, which counts Teilhard de Chardin among its founders, allows the development of a new approach to the theology of nature. In this approach, it is actually the biosphere herself that is doing theology thanks to her thinking sphere: the noosphere.     

Contrasting Acquisition-Focused and Performance-Focused Models of Acquired Behavior

What is encoded during a learning experience? In a learning situation, a training (acquisition) phase is often followed by a test phase. Acquisition-focused models (most associative models) emphasize information processing that occurs during training and assume that only summary statistics (associative values) are retained to influence behavior during testing. Performance-focused models (a k a "computational" models) emphasize information processing that occurs at test and often assume fairly comprehensive memory of prior experiences. In this article, we contrast these two families of models. We note that neither family can claim unique support from the various learning phenomena commonly cited as favoring one or the other position. Within each family, there are highly diverse models that preclude blanket generalizations. However, the acquisition-focused view that subjects retain only summary statistics suggests unrealistically impoverished memories relative to the fairly veridical memories that clearly are formed. But this oversimplifying assumption of acquisition-focused associative theories is exactly what has made them superior to performance-focused models to date in stimulating research.     

社会生物学伦理观评介

威尔逊通过社会生物学的研究,指出动物的社会行为有其生物学的基础。他认为人类的利他主义伦理也同样有着生物学基础,从而提出了以生物行为科学解释伦理本质的伦理观。社会生物学伦理观,是一座联接伦理学与自然科学的桥梁。当今时代,进一步深入研究社会生物学伦理观,对于完善伦理学的科学基础,对于如何恰当地开展社会伦理教育都具有重要的意义。     

The intrinsic difficulty of recursive functions

This paper deals with a philosophical question that arises within the theory of computational complexity: how to understand the notion of INTRINSIC complexity or difficulty, as opposed to notions of difficulty that depend on the particular computational model used. The paper uses ideas from Blum's abstract approach to complexity theory to develop an extensional approach to this question. Among other things, it shows how such an approach gives detailed confirmation of the view that subrecursive hierarchies tend to rank functions in terms of their intrinsic, and not just their model-dependent, difficulty, and it shows how the approach allows us to model the idea that intrinsic difficulty is a fuzzy concept. Jan Zygmunt     

Tableau algorithms for factor analysis by instrumental variable methods

Simple tableau algorithms are given for the noniterative instrumental variable (FABIN 2) and two stage regression (FABIN 3) factor loading estimates of Hägglund. Corresponding generalized least squares estimates of factor covariances and unique variances are introduced. An example is given for the purpose of illustration and comparison.This research was supported by NSF Grant MCS-8301587.     

Teaching Bioethics to a Large Number of Biology and Pharma Students: Lessons Learned

To be made aware of bioethical issues related to their disciplines, undergraduate students in biology and pharmaceutical sciences at the University of Basel are required to enroll in the bioethics course called “Introduction to Bioethics”. This article describes the chances and challenges faced when teaching a large number of undergraduate biology and pharmaceutical sciences students. Attention is drawn to the relevance and specific ethical issues that biology and pharmaceutical sciences students may be confronted with and to how these could be integrated into ethics curricula. Results from a survey addressing the knowledge and opinion of students taking the course in spring semester 2012, 2013, and 2014 are presented and discussed. Finally, we describe the lessons learned and how we have improved the course based on students’ feedback throughout the following years.     

Much ado about nothing? Why going non-semantic is not merely semantics

This paper argues that deciding on whether the cognitive sciences need a Representational Theory of Mind matters. Far from being merely semantic or inconsequential, the answer we give to the RTM-question makes a difference to how we conceive of minds. How we answer determines which theoretical framework the sciences of mind ought to embrace. The structure of this paper is as follows. Section 1 outlines Rowlands’s (2017) argument that the RTM-question is a bad question and that attempts to answer it, one way or another, have neither practical nor theoretical import. Rowlands concludes this because, on his analysis, there is no non-arbitrary fact of the matter about which properties something must possess in order to qualify as a mental representation. By way of reply, we admit that Rowlands’s analysis succeeds in revealing why attempts to answer the RTM-question simpliciter are pointless. Nevertheless, we show that if specific formulations of the RTM-question are stipulated, then it is possible, conduct substantive RTM debates that do not collapse into merely verbal disagreements. Combined, Sections 2 and 3 demonstrate how, by employing specifying stipulations, we can get around Rowlands’s arbitrariness challenge. Section 2 reveals why RTM, as canonically construed in terms of mental states exhibiting intensional (with-an-s) properties, has been deemed a valuable explanatory hypothesis in the cognitive sciences. Targeting the canonical notion of mental representations, Section 3 articulates a rival nonrepresentational hypothesis that, we propose, can do all the relevant explanatory work at much lower theoretical cost. Taken together, Sections 2 and 3 show what can be at stake in the RTM debate when it is framed by appeal to the canonical notion of mental representation and why engaging in it matters. Section 4 extends the argument for thinking that RTM debates matter. It provides reasons for thinking that, far from making no practical or theoretical difference to the sciences of the mind, deciding to abandon RTM would constitute a revolutionary conceptual shift in those sciences.