机体蛋白质复杂性与植物药复方的统一

植物药复方是中医辨证施治的主要手段。药物是通过蛋白质起作用的。蛋白质复杂多样的功能与其时空的复杂演变密切相关,复方如何对蛋白质时空产生影响、如何对其结构与功能发生作用以及两者之间相互作用、相互影响的深入研究可能发现新的生命现象,为阐明疾病发病机理以及植物药的创新研制奠定理论基础和提供技术支持。     

Attention in the pigeon: a reevaluation

During training sessions, pigeons were successively exposed to compounds consisting of a white triangle on a red background and a white circle on a green background. Key pecking intermittently produced grain reinforcers in the presence of one form-color compound. Once key pecking was confined to the compound associated with reinforcement, the elements—red, green, triangle, and circle—were presented during a test in which no reinforcement was available. Each bird pecked nearly exclusively in the presence of the color previously associated with reinforcement, a result that might be interpreted as indicating that the subjects had attended to color, but not form during training. Pecking was next reinforced when either the triangle or the circle was present. Pecking in the presence of the form previously associated with reinforcement was acquired more rapidly. This result suggests that the birds had learned about the forms during training, and that conclusions about attention based on the lack of differential pecking in the nonreinforcement test may not be appropriate.     

Control by the auditory or the visual element of a compound discriminative stimulus: effects of feedback.

Groups of pigeons were trained to depress a treadle in the presence of a compound stimulus consisting of a tone and a red houselight (a) to avoid electric shock, or (b) to obtain grain. Immediate, exteroceptive feedback was equated for avoidance and appetitive groups within an experiment, but varied across experiments from elevation of a nonilluminated feeder to darkening of the chamber, termination of the tone, and elevation of an illuminated feeder. Responding in the absence of the compound stimulus postponed its next occurrence. After performance had stabilized, the degree to which each element controlled treadle pressing was determined. Generally, in the appetitive tests, the red light controlled much more responding than did the tone, but in the avoidance tests, the tone controlled more responding than did the red light.     

SELECTIVE ASSOCIATIONS PRODUCED SOLELY WITH APPETITIVE CONTINGENCIES: THE STIMULUS-REINFORCER INTERACTION REVISITED

In studies reporting stimulus-reinforcer interactions in traditional conditioning paradigms, when a tone-light compound was associated with food the light gained stimulus control, but when the compound was paired with shock avoidance the tone gained control. However, the physical nature of the reinforcerrelated events (food vs. shock) presented in the presence of the tone-light compound was always confounded with the conditioned hedonic value of the compound's presence relative to its absence. When the compound was paired with shock, its presence was negative relative to its absence (which was shock-free). In contrast, when the compound was paired with food, its presence was positive relative to its absence (which was food-free). The present experiment dealt with this confounding effect by conditioning a tone-light compound to be positive or negative, relative to its absence, solely with food reinforcement. One group of rats received food for responding in the presence of the tone-light compound and no food in its absence. The other group also responded in the presence of the compound, but received food only in its absence. These rats were trained on a chained schedule in which responding in the presence of the tone-light compound produced a terminal link signaled by the absence of the compound; responding ceased in the terminal link because it delayed food delivery. In a test session to assess stimulus control by the elements of the compound, tone and light were presented separately under extinction conditions. Rats that had been exposed to a positive correlation between food and the compound emitted almost double the responses in the presence of the light as in the presence of the tone. In comparison, rats that had been exposed to a negative correlation emitted only two thirds as many responses in the presence of the light as in the presence of the tone. Because this selective association was produced using only food, it appears that the contingencies under which a reinforcer is presented, rather than (or as well as) its physical properties, can generate the selective associations previously attributed to “stimulus-reinforcer interactions.” This could mean that regardless of the class of reinforcer that ultimately maintains responding (appetitive or aversive), the contingency-generated hedonic value of the compound stimulus may influence the dominant modality of stimulus control.     

Reading comprehension with the Go/No-Go procedure with compound stimuli

The present study investigated whether the Go/No-Go procedure with compound stimuli produces emergent relations among dictated words (A), pictures (B), and printed words (C) and the emergence of textual behavior (CD) using a multiple probe design across word sets. Three preschool children were exposed to 4 phases: (1) pretests for BC, CB, and CD relations, (2) pretraining with known stimuli, (3) AB and AC training, and (4) posttests for BC, CB, and CD relations. During AB and AC training, responses to A1B1, A2B2, A1C1, and A2C2 compound stimuli, but not to A1B2, A2B1, A1C2, and A2C1, were reinforced. The results showed that all participants met the learning criterion and demonstrated emergence of BC and CB relations (i.e., relations between pictures and printed words), and CD relations (i.e., textual behavior) after training. These results suggest that the Go/No-Go procedure with compound stimuli is an effective alternative for establishing reading comprehension.     

Love and the Problem of Evil

The focus of this paper is the virtual certainty that much of what we must prize in loving any human person would not have existed in a world that did not contain much of the evil that has occurred in the history of the actual world. It is argued that the appropriate response to this fact must be some form of ambivalence, but that lovers have reason to prefer an ambivalence that contextualizes regretted evils in the framework of what we welcome in human life.

The same but different: an empirical investigation of the reducibility principle

According to classical utility theory the valuation of any lottery should depend only on its outcomes and their respective probabilities, and should not be affected by the nature, complexity and structure of the chance mechanism. Previous research has documented systematic violations of this principle. For example, most subjects prefer lotteries in which the payoffs are contingent on the joint occurrence of multiple (high probability) events to simple lotteries, and lotteries in which the earlier stages offer higher probabilities than the later stages. We review the various violations of this principle and suggest a classification into two major types associated with misunderstanding of chance mechanisms and attitude towards the chance mechanism and process. In the present study 40 subjects were presented with 30 pairs of binary gambles. In any given pair the lotteries had identical outcomes and equal ‘reduced’ probabilities (and thus equal expected values). However, the chance mechanisms varied along a variety of factors such as the size of the sample space, the number of stages, temporal ordering, order of probabilities, their transparency and time constraints. Half the subjects saw lotteries involving gains and the other half considered only losses. After choosing one lottery in each pair, the subjects were asked to explain and justify their choices. The findings revealed systematic violations of the reducibility principle: subjects displayed a preference for lotteries with larger sample spaces, and for lotteries that allow quicker resolutions in the earlier stages. A clear distinction between some patterns of preferences in the gains and loss domains was revealed. In gambles involving gains subjects preferred to have the highest probability on the first stage (and the lowest probability on the last stage), but displayed the opposite preferences for losses. A content analysis of the subjects' stated reasons for their choices identified eight major categories. The most frequently invoked were hope, fun, simplicity, stress and time. Copyright © 2001 John Wiley & Sons, Ltd.     

Argument Structure and Disciplinary Perspective

Many in the informal logic tradition distinguish convergent from linked argument structure. The pragma-dialectical tradition distinguishes multiple from co-ordinatively compound argumentation. Although these two distinctions may appear to coincide, constituting only a terminological difference, we argue that they are distinct, indeed expressing different disciplinary perspectives on argumentation. From a logical point of view, where the primary evaluative issue concerns sufficient strength of support, the unit of analysis is the individual argument, the particular premises put forward to support a given conclusion. Structure is internal to this unit. From a dialectical point of view, where the focus concerns how well a critical discussion comes to a reasoned conclusion of some disputed question, the argumentation need not constitute a single unit of argument. The unit of dialectical analysis will be the entire argumentation made up of these several arguments. The multiple/co-ordinatively compound distinction is dialectical, while the linked/convergent distinction is logical. Keeping these two pairs of distinctions separate allows us to see certain attempts to characterize convergent versus linked arguments as rather characterizing multiple versus co-ordinatively compound arguments, in particular attempts of Thomas, Nolt, and Yanal, and to resolve straightforwardly conflicts, tensions, or anomalies in their accounts. Walton's preferred Suspension/Insufficient Proof test to identify linked argument structure correctly identifies co-ordinatively compound structure. His objection to using the concept of relevance to explicate the distinction between linked and convergent structure within co-ordinatively compound argumentation can be met through explicating relevance in terms of inference licenses. His counterexample to the Suspension/No Support test for identifying linked structure which this approach supports can itself be straightforwardly dealt with when the test is explicated through inference licenses.     

整形外科的临床治疗决策分析

在生物心理社会医学模式下,以循证医学为基础的共享型临床决策成为主导.整形外科疾病有着诊断容易、治疗方法多样、效果不一、患者年龄小、心理脆弱、大众认知有一定误区等特点,更需要在情感和实践上体现对患者的理解和尊重,真正实现医生患者共同参与的共事型临床决策.