The crane's foot: The rise of the pedigree in human genetics

The standard pedigree used by geneticists is intimately connected to the history of genetics. Pedigrees drawn today are based on standards established in the early decades of the twentieth century. Those standards were established by geneticists who pursued an active interest in eugenics. The slightly different standards followed in America vs. England to some extent followed the stronger support of Mendelism by the Americans, as well as the individual preferences of the leading human geneticists in those countries.     

FUNCTIONAL COMMUNICATION TRAINING WITH AND WITHOUT EXTINCTION AND PUNISHMENT

Functional communication training has been reported to be a promising treatment for severe behavior problems. In this study, functional communication training alone and combined with extinction and/or punishment was evaluated for 4 clients with severe retardation, behavior problems, and communication deficits. The participants were inpatients on a hospital unit for treatment of severe behavior disorders. They received individualized interventions based on functional assessment that included reinforcement of a communication response with the same function as their destructive behavior. Results showed that for some patients, functional communication training was not sufficient to produce clinically significant reductions in destructive behavior, and the combination of training plus punishment produced the largest and most consistent reductions.     

Effects of differences between stimuli, responses, and reinforcer rates on conditional discrimination performance

In a discrete-trial conditional discrimination procedure, 4 pigeons obtained food reinforcers by pecking a key with a short latency on trials signaled by one stimulus and by pecking the same key with a long latency on trials signaled by a second stimulus. The physical difference between the two stimuli and the temporal separation between the latency values required for reinforcement were varied factorially over four sets of conditions, and the ratio of reinforcer rates for short and long latencies was varied within each set of conditions. Stimulus discrimination varied directly with both stimulus and response differences and was unaffected by the reinforcer ratio. Sensitivity to reinforcement, estimated by generalized-matching-law fits to the data within each set of conditions, varied directly with the response difference but inversely with the stimulus difference arranged between sets of conditions. Because variations in stimulus differences, response differences, and reinforcer differences did not have equivalent effects, these findings question the functional equivalence of the three terms of the discriminated operant: antecedent stimuli, behavior, and consequences.     

The substitutability of reinforcers

Substitutability is a construct borrowed from microeconomics that describes a continuum of possible interactions among the reinforcers in a given situation. Highly substitutable reinforcers, which occupy one end of the continuum, are readily traded for each other due to their functional similarity. Complementary reinforcers, at the other end of the continuum, tend to be consumed jointly in fairly rigid proportion, and therefore cannot be traded for one another except to achieve that proportion. At the center of the continuum are reinforcers that are independent with respect to each other; consumption of one has no influence on consumption of another. Psychological research and analyses in terms of substitutability employ standard operant conditioning paradigms in which humans and nonhumans choose between alternative reinforcers. The range of reinforcer interactions found in these studies is more readily accommodated and predicted when behavior-analytic models of choice consider issues of substitutability. New insights are gained into such areas as eating and drinking, electrical brain stimulation, temporal separation of choice alternatives, behavior therapy, drug use, and addictions. Moreover, the generalized matching law (Baum, 1974) gains greater explanatory power and comprehensiveness when measures of substitutability are included.     

Delay reduction: current status.

Delay-reduction theory states that the effectiveness of a stimulus as a conditioned reinforcer may be predicted most accurately by the reduction in time to primary reinforcement correlated with its onset. We review support for the theory and then discuss two new types of experiments that assess it. One compares models of choice in situations wherein the less preferred outcome is made more accessible; the other investigates whether frequency of conditioned reinforcement affects choice beyond the effect exerted by frequency of primary reinforcement.     

Violations of transitivity: Implications for a theory of contextual choice

Violations of strong stochastic transitivity in concurrent-chains choice were first reported by Navarick and Fantino. In a series of articles, Navarick and Fantino concluded that neither a unidimensional model capable of predicting exact choice probabilities nor a fixed-variable equivalence rule was possible for the concurrent-chains procedure. I show that when choice is modeled contextually (i.e., when preference for a schedule is affected by factors other than the schedule itself, e.g., aspects of the alternative schedule), a unidimensional, exact-choice probability model is possible that both predicts the intransitivities reported by Navarick and Fantino and provides a fixed-variable equivalence rule for the concurrent-chains procedure. The contextual model is an extension of the generalized matching law and violates a key assumption underlying traditional choice models—simple scalability—because of (a) schedule interdependence and (b) bias from procedural contingencies. Therefore, strong stochastic transitivity cannot be expected to hold. Contextual scalability is analyzed to reveal a hierarchy of context effects in choice. Navarick and Fantino's intransitivities can be satisfactorily explained by bias. If attribute sensitivity is context dependent, however, and if there are similarity structures among choice alternatives, the contextual model is shown to be able to predict violations of ordinal preference. Therefore, it may be possible to formulate a deterministic, general psychophysical model of choice as a behavioral alternative to probabilistic, multidimensional choice theories.     

Adaptation, teleology, and selection by consequences

This paper presents and defends the view that reinforcement and natural selection are selection processes, that selection processes are neither mechanistic nor teleological, and that mentalistic and vitalistic processes are teleological but not mechanistic. The differences between these types of processes are described and used in discussing the conceptual and methodological significance of “selection type theories” and B. F. Skinner's radical behaviorist view that “operant behavior is the field of intention, purpose, and expectation. It deals with that field precisely as the theory of evolution has dealt with another kind of purpose” (1986, p. 716). The antimentalism of radical behaviorism emerges as a post-Darwinian extension of Francis Bacon's (and Galileo's) influential view that “[the introduction of final causes] rather corrupts than advances the sciences” (Bacon, 1905, p. 302).     

Unit price as a useful metric in analyzing effects of reinforcer magnitude.

In this paper, we applied the behavioral-economic concept of unit price to the study of reinforcer magnitude in an attempt to provide a consistent account of the effects of reinforcer magnitude on behavior. Recent research in the experimental analysis of behavior and in behavioral pharmacology suggests that reinforcer magnitude interacts with the schedule of reinforcement to determine response rate and total consumption. The utility of the unit-price concept thus stems from its ability to quantify this interaction as a cost-benefit ratio (i.e., unit price = characteristics of the schedule of reinforcement divided by magnitude of reinforcement). Research employing the unit-price concept has shown that as unit price increases, a positively decelerating function exists for consumption (i.e., a function with an increasingly negative slope, when plotted on log coordinates) and a bitonic function exists for response rate. Based on these findings, the present analysis applied the unit-price concept to those studies of reinforcer magnitude and drug self-administration that examined the effects of reinforcer magnitude on response rate using simple schedules of reinforcement (e.g., fixed-ratio schedule). This resulted in three findings: (a) Reinforcer-magnitude manipulations and schedule manipulations interact in a manner that can be quantified in terms of unit price as benefit and cost factors, respectively; (b) different reinforcer-magnitude manipulations are functionally interchangeable as benefit factors in the unit-price ratio; and (c) these conclusions appear warranted despite the differences in reinforcers (food or drug), species (dogs, monkeys, or rats), and schedules (interval or ratio), and despite the fact that these studies were not designed for a unit-price analysis. In methodological terms, these results provide further evidence that employing the unit-price concept is a parsimonious method for examining the effects of reinforcer magnitude. In theoretical terms, these results suggest that a single process may underlie the effect of combined reinforcer-magnitude and schedule manipulations.     

The asymptotic posterior normality of the latent trait in an IRT model

It has long been part of the item response theory (IRT) folklore that under the usual empirical Bayes unidimensional IRT modeling approach, the posterior distribution of examinee ability given test response is approximately normal for a long test. Under very general and nonrestrictive nonparametric assumptions, we make this claim rigorous for a broad class of latent models.This research was partially supported by Office of Naval Research Cognitive and Neural Sciences Grant N0014-J-90-1940, 442-1548, National Science Foundation Mathematics Grant NSF-DMS-91-01436, and the National Center for Supercomputing Applications. We wish to thank Kumar Joag-dev and Zhiliang Ying for enlightening suggestions concerning the proof of the basic result.The authors wish to thank Kumar Joag-Dev, Brian Junker, Bert Green, Paul Holland, Robert Mislevy, and especially Zhiliang Ying for their useful comments and discussions.     

Schedule-induced defecation by rats during ratio and interval schedules of food reinforcement.

Lever pressing in rats was maintained by continuous and intermittent schedules of food while defecation was monitored. In Experiment 1, reinforcement densities were matched across variable-ratio and variable-interval schedules for three pairs of rats. Defecation occurred in all 3 rats on the variable-ratio schedule and in all 3 rats on the yoked variable-interval schedule. In Experiment 2, fixed-ratio and fixed-interval schedules with similar reinforcement densities maintained lever pressing. Defecation occurred in 3 of 4 rats on the fixed-ratio schedule and in 4 of 4 rats on the fixed-interval schedule. Almost no defecation occurred during continuous reinforcement in either experiment. These results demonstrate that defecation may occur during both ratio and interval schedules and that the inter-reinforcement interval is more important than the behavioral requirements of the schedule in generating schedule-induced defecation.