Cognitive Neuropsychology of HIV-Associated Neurocognitive Disorders

Advances in the treatment of the human immunodeficiency virus (HIV) have dramatically improved survival rates over the past 10 years, but HIV-associated neurocognitive disorders (HAND) remain highly prevalent and continue to represent a significant public health problem. This review provides an update on the nature, extent, and diagnosis of HAND. Particular emphasis is placed on critically evaluating research within the realm of cognitive neuropsychology that aims to elucidate the component processes of HAND across the domains of executive functions, motor skills, speeded information processing, episodic memory, attention/working memory, language, and visuoperception. In addition to clarifying the cognitive mechanisms of HAND (e.g., impaired cognitive control), the cognitive neuropsychology approach may enhance the ecological validity of neuroAIDS research and inform the development of much needed novel, targeted cognitive and behavioral therapies. The research described was supported by MH73419 and MH62512 from the National Institutes of Health. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense, nor the United States Government.     

From end time to the time of the end: some reflections about the emergence of subjectivity

Abstract :  In this article, the author presents the first ten years of the analysis of a young patient who just barely escaped an onset of schizophrenia. The patient showed defences of the self that had been frozen with regard to his relationship to time, and had shut him outside of any rapport with time, forcing him to seek—as desperately as unconsciously—a 'time of the end', a present time.
He explores different 'lived times': circular and linear times that are both classical in Jungian theory; he then describes what he calls subjective linear 'lived time' as a modality for opening up instinctual objectivity to subjectivity's access to the symbolic. In his theorization of this passage, he uses the Greek notion of Kairos as well as the French psychoanalyst Jean Laplanche's theory of originary seduction.
Finally, he ties this transition to recent theories in physics of complex systems, also called chaos theory, and poses the hypothesis that this model can represent two essential qualities of subjectivity: its non-predictability and its non-reproductability.     

THE MAGICIAN IN THE WORLD: BECOMING, CREATIVITY, AND TRANSVERSAL COMMUNICATION

This essay interprets the meaning of one of the cards in aTarot deck, "The Magician," in the context of process philosophy in the tradition of Alfred North Whitehead. It brings into the conversation the philosophical legacy of American semiotician Charles Sanders Peirce as well as French poststructuralist Gilles Deleuze. Some of their conceptualizations are explored herein for the purpose of explaining the symbolic function of the Magician in the world. From the perspective of the logic of explanation, the sign of the Magician is an index of nonmechanistic, mutualist or circular, causality that enables self-organization embedded in coordination dynamics. Its action is such as to establish an unorthodox connection crossing over the dualistic gap between mind and matter, science and magic, process and structure, the world without and the world within, subject and object, and human experience and the natural world, thereby overcoming what Whitehead called the paradox of the connectedness of things. The Magician represents a certain quality that acts as a catalytic agent capable of eliciting transmutations, that is, the emergence of novelty. I present a model for process∼structure that uses mathematics on the complex plane and the rules of projective geometry. The corollary is such that the presence of the Magician in the world enables a particular organization of thought that makes pre-cognition possible.     

Some factors that influence the acquisition of complex, stereotyped, response sequences in pigeons

Two pigeons were required to peck six to nine illuminated response keys. A response on any one of the keys darkened that key. When each key had been darkened, a reinforcer was delivered. No specific sequence of key pecking was ever required. The keys were presented in various matrices: three by two, three by three, horizontal rows, and vertical columns. The keys either presented the same stimulus, white light; or each key presented a different stimulus, a color or form. The results indicated that although there were 720 to 362,880 different sequences that would produce reinforcement, each bird developed a particular, stereotyped sequence that dominated its behavior. Variability among the birds across phases yielded less than 60 sequences, .0001 to 6 percent of the possible sequences. The data suggest that a reinforcement contingency that includes “free choice” of response sequence will produce stereotypical response sequences that function as complex “units” of behavior.     

Causality assessment in epidemiology

Epidemiology relies upon a broad interpretation of determinism. This paper discusses analogies with the evolution of the concept of cause in physics, and analyzes the classical nine criteria proposed by Sir Austin Bradford Hill for causal assessment. Such criteria fall into the categories of enumerative induction, eliminative induction, deduction and analogy. All of these four categories are necessary for causal assessment and there is no natural hierarchy among them, although a deductive analysis of the study design is preliminary to any assessment.     

Responding in the squirrel monkey under fixed-ratio schedules of stimulus termination

Key pressing was maintained under a fixed-ratio schedule in which electric shock was scheduled for delivery at a fixed time (t seconds) after each stimulus onset, and every n^th response terminated the stimulus and initiated a timeout from shock. Under this procedure, the higher the rate of responding, the briefer the duration of the stimulus presentation and the lower the frequency of shock delivery. The effects of several schedule parameters were studied to determine whether the maintenance of responding was dependent on an inverse relation between response rate and shock frequency. Shock rate and shock frequency were made independent of response rate by decreasing the value of t to 0.5 second and delivering shock only during the first presentation of the stimulus after a fixed time, including stimulus and timeout durations, had elapsed since the previous shock. The experiments showed that shock frequency and response rate are inversely related when t is of relatively long duration compared to the value of the fixed-ratio parameter, but that a decrease in shock rate or frequency due to a high rate of responding is not necessary for the maintenance of responding under a fixed-ratio schedule of stimulus termination.     

Allocation of complex, sequential operants on multiple and concurrent schedules of reinforcement

Pigeons could produce food by pecking exactly four times on each of two keys, in any order. In the first experiment, these response sequences were reinforced on a series of multiple schedules of variable-interval reinforcement. In the second experiment, these response sequences were reinforced on a series of concurrent schedules of reinforcement. In both experiments, highly stereotyped response sequences developed. If these response sequences were treated as individual responses, the resulting data conformed to what is typically reported in studies of multiple and concurrent schedules involving individual responses. For example, behavioral contrast was observed with the multiple schedules, and matching was observed with the concurrent schedules. However, schedule manipulation had no effect on within-sequence characteristics of responses like accuracy, stereotypy, or rate. These data constitute further evidence that response sequences can become functional behavioral units.     

The influence of complexes on implicit learning

A century ago, Jung looked into the unconscious through complexes by using word association tests. Jung wrote, 'modern psychology with its investigation of complexes has opened up a psychic taboo area riddled with hopes and fears', and complexes remain an unexplored taboo area of research. In the present study, we have investigated the influence of complexes on unconscious cognitive processing, in particular on implicit learning. We have found that complexes shown to disturb conscious cognitive processing in fact enhanced the attention of the subjects and their performance on an implicit learning task. These results suggest that complexes are not just abstractions, but have various actual influences on both conscious and unconscious processing.     

Figures of Time in Evolution of Complex Systems

Owing to intensive development of the theory of self-organization of complex systems called also synergetics, profound changes in our notions of time occur. Whereas at the beginning of the 20th century, natural sciences, by picking up the general spirit of Einstein's theory of relativity, consider a geometrization as an ideal, i.e. try to represent time and force interactions through space and the changes of its properties, nowadays, at the beginning of the 21st century, time turns to be in the focus of attention. It turns to be possible to represent space through time, because synergetics shows that historical and evolutionary stages of development of a complex structure can be found now, in its present spatial configuration. A whole series of paradoxical notions, such as “the influence of the future upon the present”, a “possibility of touching of a rather remote future today”, “availability of the past and the future now, in praesenti”, “irreversibility and elements of reversibility in the course of evolutionary processes in time”, “discrete unites, quanta of time”, appear in synergetics.     

Chasing the Numinous: Hungry Ghosts in the Shadow of the Psychedelic Renaissance

In recent years a renewed scientific, public and commercial interest in psychedelic medicines can be observed across the globe. As research findings have been generally promising, there is hope for new treatment possibilities for a number of difficult-to-treat mental health concerns. While honouring positive developments and therapeutic promise in relation to the medical use of psychedelics, this paper aims to shine a light on some underlying psycho-cultural shadow dynamics in the unfolding psychedelic renaissance. This paper explores whether and how the multi-layered collective fascination with psychedelics may yet be another symptom pointing towards a deeper psychological and spiritual malaise in the modern Western psyche as diagnosed by C. G. Jung. The question is posed whether the West’s feverish pursuit of psychedelic medicines—from individual consumption to entheogenic tourism, from capitalist commodification of medicines and treatments to the increasing number of ethical scandals and abuse through clinicians and self-proclaimed shamans—is related to a Western cultural complex. As part of the discussion, the archetypal image of the Hungry Ghost, known across Asian cultural and religious traditions, is explored to better understand the aforementioned shadow phenomena and point towards mitigating possibilities.