睡眠和记忆之间关系的研究

睡眠和记忆是人类重要的功能．人们对于二者之间的关系一直非常感兴趣、本文综述了近年来睡眠和记忆之间关系研究的主要成果,从动物和人的不同角度进行讨论．并进一步综述了近年有关事件相关电位和功能成像等的研究成果．在有关人的探讨中,进一步讨沦了快波睡眠,慢波睡眠、睡眠的组织、睡眠缺失等对记忆的影响、     

The influence of competitive status (winner/loser) on the behavior of male rats in three models of anxiety

Studies indicate that features such as prior stressful experience, strain, gender, and age can influence the behavior of rats in animal models of anxiety. In the present study, we examined the possible influence of competitive status (winner/loser) in three such models: the elevated plus‐maze, the open field, and the social interaction test. One hundred to 135‐day‐old male Wistar rats were conditioned to traverse a straight runway tube to obtain food. Subsequently, two rats were placed at the same time in the runway tube and, being unable to pass each other, one of them pushed the other to the opposite end‐box. The rats were categorized as winners or losers in this competition. One week after the straight runway tube test, the rats were submitted to the anxiety models, where it was observed that winner rats showed greater locomotor activity than the losers in the three models studied. Furthermore, winner rats showed less immobility and higher central and total locomotor activity in the open field and a greater duration of social interaction in the social interaction test. These results suggest that competitive status has an influence on the locomotor activity of rats in animal models of anxiety. However, whether competitive status influences anxiety as assessed in these models is unclear, and further investigations are warranted. Aggr. Behav. 28:164–171, 2002. © 2002 Wiley‐Liss, Inc.     

Exogenous testosterone and social experience each enhance the development of aggressive behavior in Cyprinodon variegatus

The combined effects of testosterone and social experience from the time of hatching on development of aggressive behaviors in Cyprinodon variegatus were investigated. Social experience was defined as a rearing condition allowing visual, tactile, chemosensory, and auditory contact with zero, three, or 15 additional conspecifics. Behaviors were videotaped once weekly from 3 weeks to 4 months post-hatching, using the focal animal method, and an ethogram was constructed. At 3 months post-hatching, half the fish were injected once with testosterone propionate (2 μg/g b. w., i. p., vehicle-Ringer's solution) and the other half were injected with Ringer's isotonic saline solution. Testosteronetreated subjects showed significantly greater frequencies and durations of behaviors that may be related to aggression than did saline controls. Two weeks after the treatments, a round-robin tournament was conducted between testosterone- and saline-treated fish from each rearing condition. Testosterone-treated fish won significantly more encounters than did saline-treated subjects over all rearing conditions. Furthermore, significantly more aggressive acts were displayed by fish raised in the groups of 16 and the groups of four than did the Isolates. Although the number of aggressive acts exhibited by the group of 16 was greater than the group of four, the difference was not statistically significant.     

Protection of animal research subjects

The use of experimental animals, mostly rodents, in biomedical research and especially in oncology and immunology should be acknowledged with respect, recognizing the contribution of animal experimentation in the fascinating scientific progress in these disciplines of research. It is an obligation of the investigator to justify the scientific and ethical aspects of each study requiring the use of animals. The international guiding principles for using animals in biomedical research are well defined and have been distributed worldwide by the International Council for Laboratory Animal Science (ICLAS) since 1956, when this Organization was founded. In Poland the ICLAS philosophy and principles are highly respected and were implemented firstly by the members of the Commission on Biology of Experimental Animals appointed in 1962 by the Department of Medical Science of the Polish Academy of Science in Warsaw. Animal Protection Acts, first proclaimed in 1928 were gradually modified and improved. Actual legislation (enacted in 1997, 2003 and 2005) is consistent with EU Directives (86/609/EEC) and follows the internationally recommended principles that include ICLAS guidelines concerning animal welfare and care condition in biomedical research. The problem of “alternative methods” is briefly discussed. Dr. Donald Boisvert, CCAC — Canadian Council on Animal Care A lecture on the subject of this paper was presented at the 6th International Bioethics Conference entitled ‘The Responsible Conduct of Basic and Clinical Research’, held in Warsaw, Poland, 3–4 June 2005. The author is the National Representative of Polish Academy of Science to the International Council for Laboratory Animal Science (ICLAS) and a Member of the ICLAS Governing Board.     

Reasonable Partiality and Animal Ethics

Moral psychology is often ignored in ethical theory, making applied ethics difficult to achieve in practice. This is particularly true in the new field of animal ethics. One key feature of moral psychology is recognition of the moral primacy of those with whom we enjoy relationships of love and friendship – philia in Aristotles term. Although a radically new ethic for animal treatment is emerging in society, its full expression is severely limited by our exploitative uses of animals. At this historical moment, only the animals with whom we enjoy philia – companion animals – can be treated with unrestricted moral concern. This ought to be accomplished, both for its own sake and as an ideal model for the future evolution of animal ethics.     

Family of the forest: Fatal enmeshment and other systems issues in the animal world

While the observation of non-human animal behavior has been a major means of developing psychological theories, it has been rarely used by marriage and family therapists to devise or explain systemic ideas. Jane Goodall's multigenerational research on the Flo family of wild chimpanzees in Gombe, Tanzania, as presented in her own and other's writing, and especially in Hugo van Lawick's documentary film,People of the Forest, offers a clear example of how systems concepts' application to animal families may have theoretical, pedagogical, and clinical utility.My thanks to my good friend, Violet Richman, who suggested the subject for this paper.