Animal experimentation

Millions of animals are used every year in oftentimes extremely painful and distressing scientific procedures. Legislation of animal experimentation in modern societies is based on the supposition that this is ethically acceptable when certain more or less defined formal (e.g. logistical, technical) demands and ethical principles are met. The main parameters in this context correspond to the “3Rs” concept as defined by Russel and Burch in 1959, i.e. that all efforts to replace, reduce and refine experiments must be undertaken. The licensing of animal experiments normally requires an ethical evaluation process, oftentimes undertaken by ethics committees. The serious problems in putting this idea into practice include inter alia unclear conditions and standards for ethical decisions, insufficient management of experiments undertaken for specific (e.g. regulatory) purposes, and conflicts of interest of ethics committees’ members. There is an ongoing societal debate about ethical issues of animal use in science. Existing EU legislation on animal experimentation for cosmetics testing is an example of both the public will for setting clear limits to animal experiments and the need to further critically examine other fields and aspects of animal experimentation. This paper was presented at the 6th International Bioethics Conference on the subject of ‘The Responsible Conduct of Basic and Clinical Research’, held in Warsaw, Poland, 3–4 June 2005. The paper has been expanded from an article to be published in the forthcoming Council of Europe publication entitled “Animal Protection and Welfare”.     

The Regulation of Animal Research and the Emergence of Animal Ethics: A Conceptual History

The history of the regulation of animal research is essentially the history of the emergence of meaningful social ethics for animals in society. Initially, animal ethics concerned itself solely with cruelty, but this was seen as inadequate to late 20^th-century concerns about animal use. The new social ethic for animals was quite different, and its conceptual bases are explored in this paper. The Animal Welfare Act of 1966 represented a very minimal and in many ways incoherent attempt to regulate animal research, and is far from morally adequate. The 1985 amendments did much to render coherent the ethic for laboratory animals, but these standards were still inadequate in many ways, as enumerated here. The philosophy underlying these laws is explained, their main provisions are explored, and future directions that could move the ethic forward and further rationalize the laws are sketched.     

Agent Perception in Children with and Without Imaginary Companions

This study examined whether children with and without imaginary companions differed in their attributions of agency to inanimate objects. In Study 1, preschool children were shown animation movies in which two geometric figures moved with systematic interaction or randomly. Then, children were asked about biological, emotional and cognitive properties of the figures. The results revealed that children with imaginary companions were more likely to attribute biological properties to the geometric figures that moved randomly compared to children without imaginary companions, but children with and without imaginary companions did not differ in their attributions of cognitive and emotional properties. In Study 2, children were asked about the biological, psychological and perceptual properties of a puppet and a human. Results showed that children with and without imaginary companions did not show the differences in the biological and psychological attributions. Results are discussed in terms of children's agent perception systems. Copyright © 2015 John Wiley & Sons, Ltd.     

Animal models of source memory

Source memory is the aspect of episodic memory that encodes the origin (i.e., source) of information acquired in the past. Episodic memory (i.e., our memories for unique personal past events) typically involves source memory because those memories focus on the origin of previous events. Source memory is at work when, for example, someone tells a favorite joke to a person while avoiding retelling the joke to the friend who originally shared the joke. Importantly, source memory permits differentiation of one episodic memory from another because source memory includes features that were present when the different memories were formed. This article reviews recent efforts to develop an animal model of source memory using rats. Experiments are reviewed which suggest that source memory is dissociated from other forms of memory. The review highlights strengths and weaknesses of a number of animal models of episodic memory. Animal models of source memory may be used to probe the biological bases of memory. Moreover, these models can be combined with genetic models of Alzheimer's disease to evaluate pharmacotherapies that ultimately have the potential to improve memory.     

GROUNDHOG ORACLES AND THEIR FOREBEARS

Groundhog Day animal weather forecasting ceremonies continue to proliferate around the United States despite a lack of public confidence in the oracles. This essay probes religio‐historical and original ethnographic perspectives to offer a psychological argument for why these ceremonies exist. Employing Paul Shepard's notion of a felt loss of sacred, intimate relationships with nonhuman nature, as well as Peter Homans's concept of the monument that enables mourning, this essay argues that groundhog oracles serve as monuments that allow humans experientially to attempt to heal lost sacred relationships with animals like weather forecasting bears, hedgehogs, and badgers.     

Effects of stroking horses on both humans' and horses' heart rate responses1

Abstract: The present study examined both human and horse heart rates (HRs) when humans stroked horses for 90 seconds; the subjective arousal levels of the humans were measured by the Tohoku Activation Deactivation Adjective Check List before and after stroking horses. Six male subjects with a positive attitude toward companion animals and 6 male subjects with a negative attitude were selected by their scores on the Pet Attitude Scale, and these two groups, together with a third group, of 6 subjects who were male members of the Doshisha University horse-riding club, participated in this experiment. The HRs of the human subjects during the first 10 seconds immediately after the stroking began were significantly higher than those obtained after that period, but these higher levels gradually returned to baseline levels. This tendency appears more clearly in the negative attitude group. The HRs of the horses increased during the first 20 seconds immediately after the human subjects of the NA group started stroking them, but gradually reduced as the stroking continued. The results of subjective arousal levels suggest a decrease in tension by stroking horses. These results suggest that a certain affectional interaction may exist between humans and companion animals.     

Choice by rats for enriched versus standard home cages: Plastic pipes, wood platforms, wood chips, and paper towels as enrichment items

The purpose of the present study was to determine whether simple additions to the home cages of rats made those cages preferable to standard housing arrangements. Results indicated that most rats preferred cages with wood platforms, wood chips, and paper towels to otherwise identical cages without these items. Wood chips were not, however, practical with the cages used in the present study. Plastic pipes caused no problems but were not preferred by most animals. Both wood platforms and paper towels created no problems and appeared to be useful as enrichment items. The latter were preferred to the former in a direct comparison.     

Ethical aspects of the safety of medicines and other social chemicals

The historical background of the discovery of adverse health effects of medicines, food additives, pesticides, and other chemicals is reviewed, and the development of national and international regulations and testing procedures to protect the public against the toxic effects of these drugs and chemicals is outlined. Ethical considerations of the safety evaluation of drugs and chemicals by human experimentation and animal toxicity studies, ethical problems associated with clinical trials, with the falsification of clinical and toxicological data, and with inadequate experimental methodology, are reviewed, and the ethics of the marketing of drugs and their post-marketing surveillance, are similarly considered. These ethical problems are illustrated with many specific examples, including the drugs neoarsphenamine, chloramphenicol, thalidomide, diethyl stilboestrol and benoxaprofen.     

Post‐traumatic functional recovery and reorganization in animal models: A theoretical and methodological challenge

Studies addressing cerebral functional localization face methodological and theoretical problems. Lesion experiments expect that when a functionally specialized structure is missing, its function can be deduced from the resulting impairments. Mostly, however, initial impairments are partially or fully eliminated through functional recovery. Apparently, such a recovery contradicts the notion of functional localization. In order to understand the mechanisms of recovery, improved methodology and a new theoretical framework are required. Insights into the mechanisms of recovery can be achieved by using “challenge” techniques, where functionally recovered individuals are exposed to organic and behavioral challenges, e.g. pharmacological manipulations or additional lesions, as well as modified test situations. Using such methods, a number of principles of functional recovery have emerged. We evaluate some of the available theories of post‐traumatic recovery against these principles and find that none of them can account for the principles. Finally, we present a new conceptual framework – the Reorganization of Elementary Functions (REF) model. This model reconceptualizes the term “function”, suggests mechanisms of post‐traumatic reorganizations, and resolves the contradiction between localization and functional recovery.     

ARE ANIMALS MORAL? A THEOLOGICAL APPRAISAL OF THE EVOLUTION OF VICE AND VIRTUE

I discuss controversial claims about the status of non‐human animals as moral beings in relation to philosophical claims to the contrary. I address questions about the ontology of animals rather than ethical approaches as to how humans need to treat other animals through notions of, for example, animal rights. I explore the evolutionary origins of behavior that can be considered vices or virtues and suggest that Thomas Aquinas is closer to Darwin's view on nonhuman animals than we might suppose. An appreciation of the complexity of the emotional lives of social animals and their cooperative behaviors in light of the work of animal ethologists such as Frans de Waal and Marc Bekoff suggests that social animals can be considered moral in their own terms. I discuss the charge of anthropomorphism, drawing on the work of archaeologist Steven Mithen, and consider arguments for the evolution of conscience in the work of anthropologist Christopher Boehm. Only the biological basis for the development of conscience and religion has evolved in nonhuman animals, and this should not be confused with sophisticated moral systems of analysis or particular religious beliefs found in the human community.