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观察洛铂与顺铂联合培美曲塞治疗晚期肺腺癌的疗效和不良反应。将64例肺腺癌患者分为PL组(培美曲塞+洛铂)和PC组(培美曲塞+顺铂),每2个周期评价疗效,观察不良反应。结果两组疗效无显著差异。PL组恶心、呕吐、腹泻较轻,口腔黏膜炎反应较重。结论两组疗效相当,但洛铂组不良反应较轻,耐受性好。 相似文献
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Behavioral versus Behavioral and Pharmacological Treatment in ADHD Children Attending a Summer Treatment Program 总被引:3,自引:0,他引:3
Pelham WE Gnagy EM Greiner AR Hoza B Hinshaw SP Swanson JM Simpson S Shapiro C Bukstein O Baron-Myak C McBurnett K 《Journal of abnormal child psychology》2000,28(6):507-525
As part of the behavioral treatment in the Multimodal Treatment Study of Children with ADHD (MTA), children participated in an intensive summer treatment program (STP). This study examined the differences between 57 children in the combined treatment (Comb) group, who were medicated, and 60 children in the behavioral treatment (Beh) group, who were unmedicated throughout the STP. Comb children were significantly better than Beh on 5 measures: rule following, good sportsmanship, peer negative nominations, and STP teacher posttreatment ratings of inattention/overactivity. Groups did not differ on any of the other 30 measures, and responded similarly to the STP over time. Comparisons to normative data revealed that Comb children were more likely to fall within the normative range on 6 measures. The differences between these results and the main MTA results, in which Comb was always superior to Beh, are discussed in terms of the relative intensity of combined treatments. The implications for future studies of pharmacological and behavioral treatment for ADHD are discussed. 相似文献
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Using data from a study of combined cognitive behavioral therapy (CBT) and venlafaxine XR in the treatment of generalized anxiety disorder (GAD), the current article examines the reliability and convergent validity of scales, and preliminary outcomes, for African American compared with European American patients. Internal consistency and short-term stability coefficients for African Americans (n = 42) were adequate and similar or higher compared with those found for European Americans (n = 164) for standard scales used in GAD treatment research. Correlations among outcome measures among African Americans were in general not significantly different for African Americans compared with European Americans. A subset of patients with DSM-IV–diagnosed GAD (n = 24 African Americans; n = 52 European Americans) were randomly selected to be offered the option of adding 12 sessions of CBT to venlafaxine XR treatment. Of those offered CBT, 33.3% (n = 8) of the African Americans and 32.6% (n = 17) of the European Americans accepted and attended at least one CBT treatment session. The outcomes for African Americans receiving combined treatment were not significantly different from European Americans receiving combined treatment on primary or secondary efficacy measures. 相似文献
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探讨腰-硬联合麻醉及全身麻醉用于高海拔高龄低氧患者行人工髋关节置换的临床优势。分析2010年1月~2013年11月来我院进行人工髋关节置换术的高龄(年龄>69岁)低氧患者86例,其中全麻31例,腰-硬联合麻醉55例,记录麻醉后5min、15min、30min及术毕血压、心率,术中低血压发生率,术后转ICU比例等指标。与全麻相比,腰-硬联合麻醉组血流动力学稳定、术中低血压发生率降低(P<0.05)、入住ICU几率显著降低(P<0.05)。在高海拔高龄低氧患者行人工髋关节置换术中采用腰-硬联合麻醉可以使患者麻醉效果突出,血流动力学平稳,安全有效,比全麻更有临床应用优势。 相似文献
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Pamela B. Sorensen 《Journal of Child Psychotherapy》2016,42(1):45-53
This paper explores Donald Meltzer’s concept of the claustrum, an unconscious phantasy of a space inside the body of the internal mother that has been forcibly entered and occupied. The author proposes that claustrophobic phenomena might be viewed on a continuum from the relatively ordinary to the severely pathological. Following a brief review of the characteristics of Meltzer’s claustral ‘compartments’, this continuum is explored through and illustrated by a psychoanalytic understanding of two films, Coraline, directed by Henry Selick and based on the novella by Neil Gaiman, and The Talented Mr. Ripley, based on the novel by Patricia Highsmith and directed by Anthony Minghella. The degree of entrapment in a claustrophobic world and the possibility of emerging from it into a world of authentic intimate relationships is shown to be influenced by the internal relationship to a parental couple. 相似文献
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《Behavior Therapy》2022,53(4):701-713
Although cognitive theories suggest the interactive nature of information processing biases in contributing to social anxiety, most studies to date have investigated these biases in isolation. This study aimed at (a) testing the association between social anxiety and each of the threat-related cognitive biases: attention, interpretation, and memory bias; and (b) examining the relationship between these cognitive biases in facial perception. We recruited an unselected sample of 188 adult participants and measured their level of social anxiety and cognitive biases using faces displaying angry, disgusted, happy, and ambiguous versions of these expressions. All bias tasks were assessed with the same set of facial stimuli. Regression analyses showed that social anxiety symptoms significantly predicted attention avoidance and poorer sensitivity in recognizing threatening faces. Social anxiety was, however, unrelated to interpretation bias in our sample. Results of path analysis suggested that attention bias influenced memory bias indirectly through interpretation bias for angry but not disgusted faces. Our findings suggest that, regardless of social anxiety level, when individuals selectively oriented to faces displaying anger, the faces were interpreted to be more negative. This, in turn, predicted better memory for the angry faces. The results provided further empirical support for the combined cognitive bias hypothesis. 相似文献
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Lars-Johan Schalin Phil.mag. 《Scandinavian Psychoanalytic Review》2013,36(2):115-139
The case illustration is from a long-term experience of individual psychoanalytic psychotherapy with a male patient, who started therapy when he was 15-years- old. According to DSM-IV criteria, he was diagnosed with a major depressive disorder. A psychological assessment including a Rorschach test showed a poorly integrated but well-adapted Borderline-Narcissistic personality disorder. Various classes of ant-idepressant drugs were used with equivocal or uncertain effects, and the roots and causes of the patient's negative reactions to medication had to be thoroughly investigated and dealt with during psychotherapy. Pharmacotherapy might succeed in targeting the various symptoms of depressive states, but the psychodynamic approach in a psychotherapeutic relationship widens the scope and works introspectively, allowing the patient insights to understanding the symptoms. The use of a psychotropic agent is usually based on trust and belief in its expected effect, but often the effect is not as expected. The psycho- pharmacological drug is also imbued with manifest and latent meanings which can be reached at in the psychoanalytic report. Such meanings and expectancies, and the consequent reactions affect both the patient and the psychotherapist. They have to be dealt with and overcome by psychoanalytic understanding and intervention, as well as experience and skill in use of the medicine concerned. 相似文献
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