An evolutionary system for neural logic networks using genetic programming and indirect encoding

Nowadays, intelligent connectionist systems such as artificial neural networks have been proved very powerful in a wide area of applications. Consequently, the ability to interpret their structure was always a desirable feature for experts. In this field, the neural logic networks (NLN) by their definition are able to represent complex human logic and provide knowledge discovery. However, under contemporary methodologies, the training of these networks may often result in non-comprehensible or poorly designed structures. In this work, we propose an evolutionary system that uses current advances in genetic programming that overcome these drawbacks and produces neural logic networks that can be arbitrarily connected and are easily interpretable into expert rules. To accomplish this task, we guide the genetic programming process using a context-free grammar and we encode indirectly the neural logic networks into the genetic programming individuals. We test the proposed system in two problems of medical diagnosis. Our results are examined both in terms of the solution interpretability that can lead in knowledge discovery, and in terms of the achieved accuracy. We draw conclusions about the effectiveness of the system and we propose further research directions.     

试论“肝病传脾”的诊断及治疗思路

《金匮要略》中“肝病传脾”的思想,广泛应用于临床诊断与治疗,本文以脏腑经络辨证论治思想为依据,探讨中医诊断肝痛的思路：根据症状判断病位深浅,肝病见四肢疲乏为病轻、肝病见食不消化甚至不思饮食为病重。由此判断病情轻重,为临床提供治疗依据。     

颈动脉病变的治疗现状

颈动脉病变尤其是颈动脉狭窄治疗上的分歧,颈动脉内膜切除术受欧美学者推崇,颈动脉支架成形技术受国内学者青睐,本文就近年来的文献复习发现颈动脉内膜切除术和颈动脉支架成形术各有相宜的适应证,各有优缺点,根据各自医院的设备条件、医师对颈动脉内膜切除术和颈动脉支架成形术熟悉程度来开展工作,对颈动脉狭窄治疗均有益处,存在的问题和困...     

围手术期患者的抗栓治疗

抗栓治疗的患者接受外科手术时面临栓塞和出血双重风险,本文就临床常用抗栓药物的药理特性、围手术期患者抗栓治疗需要注意的问题以及解决方案作一概述。     

心血管疾病的康复和旅游——生当如夏花般灿烂

现代社会导致了心血管疾病发病率的提高,同时人们越来越注重生活的质量和品质。作为生活品质标志之一的旅游能够改善心血管疾病康复患者的预后,愉悦他们的身心,而且一定高度的登山和商业飞行对患者基本是安全的。在康复旅游中我们仍有一些问题需要进一步解决。     

Impaired awareness of movement disorders in Parkinson’s disease

Background

This study analyzed the presence of awareness of movement disorders (dyskinesias and hypokinesias) in 25 patients with Parkinson’s disease (PD) and motor fluctuations (dyskinesias, wearing off, on–off fluctuations). Of the few studies that have dealt with this topic, none have analyzed the differences in the awareness of motor deficits by comparing the on and off states using motor scales and an extensive battery of tests to assess cognitive and behavioral functioning.

Methods

PD patients were compared on three different scales that we have devised to measure awareness of movement disorders: Global Awareness of Movement (GAM) Disorders, dyskinesia/hypo-bradykinesia rating scales.

Results

Data showed that PD patients had greater awareness and psychological suffering in the off state than in the on state. In particular, they were troubled by motor disabilities related to hypokinesias and had mood-related symptoms and a perception of disability in activities of daily living. Interestingly, patients only showed a selective reduction of awareness of movement disorders associated with executive functions and related to dyskinesias in the on state, compared to a preserved awareness of hypokinesias in the off state. On the contrary, no association with executive functions was found in the off state.

Conclusion

Our findings suggest that the dopaminergic overstimulation of mesocorticolimbic pathways may cause a dysfunction of prefrontal–subcortical connections related to the impaired insight.     

Contribution of temporal preparation and processing speed to simple reaction time in persons with Alzheimer’s disease and mild cognitive impairment

Temporal preparation was assessed in 15 Alzheimer’s disease (AD) patients, 20 persons with mild cognitive impairment (MCI) and 28 healthy older adults. Participants completed a simple reaction time task in which the preparatory interval duration varied randomly within two blocks (short versus long temporal window). Results indicated that AD and MCI patients had difficulty preparing for the shortest preparatory interval of the short temporal window. AD and MCI patients also had difficulty maintaining an optimal level of preparation up to 5 s within the short temporal window. These results suggest that AD and MCI patients might show difficulty preparing for rapidly occurring events and maintaining preparation over time. This phenomenon should be considered when using reaction time measures with such patients.     

Impaired emotion recognition in music in Parkinson’s disease

Music has the potential to evoke strong emotions and plays a significant role in the lives of many people. Music might therefore be an ideal medium to assess emotion recognition. We investigated emotion recognition in music in 20 patients with idiopathic Parkinson’s disease (PD) and 20 matched healthy volunteers. The role of cognitive dysfunction and other disease characteristics in emotion recognition was also evaluated.     

2000年～2009年国内胃食管反流病误诊文献回顾分析

为探讨胃食管反流病(GERD)误诊现状、原因和对策,对2000年～2009年10年间国内公开发表的GERD误诊报道文献97篇进行回顾性分析。既往10年间共报道GERD误诊病例2629例,共涉及38个病种,其中最常见的误诊病种是冠心病/心绞痛(48.04%)、慢性咽炎(24.23%)、支气管炎(10.27%)、支气管哮喘(8.56%)。主要误诊原因是GERD非典型表现繁杂,非消化科医生缺乏相关知识,忽视相关鉴别诊断。心血管、耳鼻喉、呼吸科医生是强化GERD认识的重点人群。     

中药在心血管疾病中应用现状与反思

具有悠久历史的中医药在现代医学中有鲜明的时代特点。心血管疾病是现代社会严重威胁生命及健康的病患。本文总结分析了古老中药在现代心血管疾病中应用的现状,并深入分析其影响因素,从而提出扬长避短的未来心血管疾病应用中药的思路。