我国转化医学发展现状的思考

转化医学在当今世界发展迅速,虽然在我国起步较晚,但取得了巨大的成就,建立了许多转化医学研究机构,积极开展合作交流,但不可避免地存在一些问题,诸如创新能力不足、顶层设计不够和人才缺乏等,为此提出相应对策和未来发展的前景,同时指出转化医学在我国不仅是学术问题,而且是社会问题.     

Shaping Medical Students' Attitudes Toward Ethically Important Aspects of Clinical Research: Results of a Randomized,Controlled Educational Intervention

The effects of research ethics training on medical students' attitudes about clinical research are examined. A preliminary randomized controlled trial evaluated 2 didactic approaches to ethics training compared to a no-intervention control. The participant-oriented intervention emphasized subjective experiences of research participants (empathy focused). The criteria-oriented intervention emphasized specific ethical criteria for analyzing protocols (analytic focused). Compared to controls, those in the participant-oriented intervention group exhibited greater attunement to research participants' attitudes related to altruism, trust, quality of relationships with researchers, desire for information, hopes about participation and possible therapeutic misconception, importance of consent forms, and deciding quickly about participation. The participant-oriented group also agreed more strongly that seriously ill people are capable of making their own research participation decisions. The criteria-oriented intervention did not affect learners' attitudes about clinical research, ethical duties of investigators, or research participants' decision making. An empathy-focused approach affected medical students' attunement to research volunteer perspectives, preferences, and attributes, but an analytically oriented approach had no influence. These findings underscore the need to further examine the differential effects of empathy-versus analytic-focused approaches to the teaching of ethics.     

Evidence-Based Practice in Psychology: An Ethical Framework for Graduate Education,Clinical Training,and Maintaining Professional Competence

Evidence-based practice is often acknowledged as the future state of psychology, yet those graduate students who will soon be applying such practices tend to hold several misconceptions about the major components within this framework. This review highlights implications for graduate education, clinical training, and professional competence in light of the movement toward evidence-based practice in psychology. These implications are discussed in relation to the close parallel between the major components of the evidence-based framework and the current Ethical Principles of Psychologists and Code of Conduct. The evidence-based framework is discussed as an ideology that promotes lifelong learning and best prepares graduate students for ethical clinical practice throughout their careers as psychologists.     

Ethical Challenges in the Treatment of Individuals With Intellectual Disabilities

The effective provision of psychotherapy services to individuals with intellectual disability requires consideration of ethical issues related to clinical competence, access to services, obligations to multiple parties, guardianship, and appropriate assessment practices. This article provides an overview of major ethical considerations with guidance for clarifying and resolving common ethical concerns. Psychologists are encouraged to expand access to psychotherapy services for this population while maintaining awareness of potential modifications, training needs, and boundaries of professional competence. The authors provide recommendations and resources for effective and ethical treatment of psychotherapy clients with intellectual disabilities.     

The Psychology of the persecutor — With reference to Costa Gavras's film Music Box

This paper is based on the author's interpretation of the film Music Box by Costa Gavras. The external and internal preconditions in the development of a persecutor are discussed in an attempt to understand the process from a socio-psychological as well as psychoanalytic viewpoint. During crises of a social nature, earlier coping strategies lose their validity, resulting in a narcissistic blow to the individual's ego. Earlier repressed primitive aspects of the personality are reactivated. When the individual is exposed to a totalitarian ideology which promises salvation from anxiety, paranoid processes become anchored and may dominate.

The protagonist in the film is approached as a case-study. By reviewing his present and past actions, the process by which the young man became a persecutor is exemplified as well as the long-term effects upon his object relations.     

The embodied analyst: from Freud and Reich to relationality

This paper presents the impact of clinical supervision on once-weekly psychoanalytically-informed training psychotherapy. The development of Oedipus complex theory is presented, culminating in Britton's work on the triangular space that opens up by working through the complex. The geometry of psychic space is described to highlight the importance of supervision, especially when training in therapy. The theme of spiders and cobwebs emerging from the clinical material provides a powerful metaphor for the tensions in psychic space. In the course of this training, the trainee therapist was at times less able to benefit fully from supervision, and thus the third position partially collapsed. Vignettes from anonymised clinical work are presented in the three ‘phases’ of this therapeutic process, illustrating the impact of the presence – and relative absence – of supervision.     

Affective facilitation and inhibition of cultural influences on reasoning

Research in South Korea and the United States examined how affective states facilitate or inhibit culturally dominant styles of reasoning. According to the affect-as-information hypothesis, affective cues of mood influence judgements by serving as embodied information about the value of accessible inclinations and cognitions. Extending this line of research to culture, we hypothesised that positive affect should promote (and negative affect should inhibit) culturally normative reasoning. The results of two studies of causal reasoning supported this hypothesis. Positive and negative affect functioned like “go” and “stop” signals, respectively, for culturally typical reasoning styles. Thus, in happy (compared to sad) moods, Koreans engaged in more holistic reasoning, whereas Americans engaged in more analytic reasoning.     

The Effects of Need for Cognition and Need for Affect on Partisan Evaluations

The voting behavior literature has advanced two prominent theoretical models of partisanship: the social psychological and rational models. Implicit to both stylized models is the assumption that all partisans process information similarly. Yet, growing research in psychology suggests that individuals possess different motivations when evaluating information. We propose that the applicability of the stylized models of partisanship is conditioned on individuals' need for cognition (NFC) and need for affect (NFA), with the social psychological model being most applicable to individuals who have a high NFA and the rational model most applicable to those with a high NFC. To test this proposition, we fielded a survey in which respondents who identified with the two major political parties in the United States (Democrat or Republican) were randomly assigned factual information that depicted either their party or their opposing party in a negative light. Respondents were then asked to assess the actions of that party and subsequently evaluate both political parties. We find evidence that is generally consistent with the proposition that the stylized models of partisanship are conditionally dependent on the extent to which individuals possess a need to engage in effortful thinking or a need to seek out emotions.     

Conceptualizations of Social Class in Afrtican American Women:

This article addresses the multiple definitions of social class in African American people and how the therapist's understanding of these definitions is important in therapeutic interventions with African American women. The article discusses: (a) the traditional ways in which social class has been defined in social science and the limits of these conceptualizations; (b) the multiple definitions of class within the African American community; and (c) treatment concerns for African American women based on class issues. Clinicians working with African American and other women who vary by class should be able to assess how class variables influence their therapeutic interventions with these women.