临床活体部分小肠移植过程中矛盾现象及处理

从1999年至今、在国内我们率先成功地施行两例临床活体部分小肠移植术,在整个处置过程中出现许多的矛盾现象。如术前为纠正患者严重的营养不良,必须给予肠外营养支持。但是,长期的肠外营养又引起患者肝功能损害,使患者无法耐受手术;对受体来讲,当然是移植的肠管越长越有利,但是在活体移植的情况下供体只能有限地提供肠管,且肠管过长受体也无法接受;手术后患者必须应用有效的免疫抑制剂来防治免疫排斥反应,而机体在免疫抑制下极易发生感染,应用强效而广的抗菌素虽然可防治细菌的感染,但是可引起菌群的失调导致真菌感染;为防止血管内血栓的形成,需应用有效的抗凝剂,但同时可导致出血倾向等等。我们体会：正确地处理这些矛盾现象是我们成功的关键。首先要抓重点,抓主要矛盾,同时应对可能出现的问题有所感知并给与预防,尽可能避免副反应的发生。     

重症加强监护医学与临床思维

重症加强监护医学的发展史,也是其临床思维的发展史,一个由个体性呼吸衰竭救治观念转化为集群性救治启动了重症加强监护学的建立,它们的发展带动亦受益于其临床思维、动态思维的发展。重症加强监护的实施,引发了医学伦理学新的思考与选择,而新的生物技术革命,必将导致重症加强监护医学及其临床思维的巨大变革。     

Who shall be Allowed to Give? Living Organ Donors and the Concept of Autonomy

Free and informed consent is generally acknowledged as the legal andethical basis for living organ donation, but assessments of livingdonors are not always an easy matter. Sometimes it is necessary toinvolve psychosomatics or ethics consultation to evaluate a prospectivedonor to make certain that the requirements for a voluntary andautonomous decision are met. The paper focuses on the conceptualquestions underlying this evaluation process. In order to illustrate howdifferent views of autonomy influence the decision if a donor's offer isethically acceptable, three cases are presented – from Germany, theUnited States, and India. Each case features a person with questionabledecision-making capacity who offered to donate a kidney for a siblingwith severe renal insufficiency. Although the normative framework issimilar in the three countries, different or sometimes even contraryarguments for and against accepting the offer were brought forward. Thesubsequent analysis offers two explanations for the differences inargumentation and outcome in spite of the shared reference to autonomyas the guiding principle: (1) Decisions on the acceptability of a livingdonor cannot simply be deducted from the principle of autonomy but needto integrate contextual information; (2) understandings of the wayautonomy should be contextualized have an important influence on theevaluation of individual cases. Conclusion: Analyzing the conceptualassumptions about autonomy and its relationship to contextual factorscan help in working towards more transparent and better justifieddecisions in the assessment of living organ donors.     

Order of Information Affects Clinical Judgment

Family practice physicians read a case vignette describing a patient with a history of lung cancer, a new transient neurological disturbance, and a normal computerized tomographic (CT) scan of the head. They then estimated the probabilities of two diagnoses: transient ischemic attack (TIA) and brain tumor. Probability estimates of TIA were lower if the history of lung cancer was presented at the end of the case rather than at the beginning. This recency effect was found for both more and less experienced physicians and whether subjects were prompted for a single end-of-sequence probability judgment or multiple step-by-step judgments after each piece of information. These results are inconsistent with Hogarth and Einhorn's (1992) belief-adjustment model, which predicts a recency effect for the step-by-step condition but a primacy effect for the end-of-sequence condition.     

对心血管病学若干进展的反思

心电起搏的发展经历曲折的过程,反映出以技术和设备为本的缺陷,以人为本可弥补这些缺陷;对介入新技术的过热应用反映了以技术为本的弊端;临床试验证据只反映某种情况下的患者共性,对试验证据的僵化理解和运用违背了循证医学的本义,以人为本可较好地解决这一矛盾;预防为主是以人为本的最好体现,应得到广泛的重视和实施。以人为本是医学的核心价值和出发点。     

吉兰-巴雷综合征的临床循证诊疗策略及思考

介绍吉兰-巴雷综合征（GBs）病因治疗的循证医学证据,主要包括血浆置换、静脉注射免疫球蛋白、糖皮质激素。简述循证医学三大要素：收集最新最好的科学研究依据、熟练的临床经验、就诊病人的特殊情况,阐发GBS的循证医学诊疗决策。阐述循证医学与经验医学的区别,循证医学并不排除科学的经验积累,并从GBS激素的使用对循证医学与专家经验的关系进行哲学思考。     

临床诊疗决策中的常见失误浅析

就常见的临床诊疗决策失误,从四个方面探讨失误的原因。首先是对患者的发病过程的相关情况掌握不全面、不准确:其次是对患者的化验与检查结果用于诊断与治疗不尽合理:第三是未处理好对患者的诊断与治疗之间的相互关系:第四是未处理好如何发挥各级各类专家的智慧、学识与经验,用于整个临床诊断与治疗的决策过程。总而言之,影响临床决策的环节多,且贯穿于整个临床过程,医师们应重视循证医学证据,始终都要把握好,不可稍有粗疏,否则将不利于提升医疗质量,难以确保医疗安全。     

关于药物临床试验伦理问题的思考

医学伦理学是伴随着科学技术的发展而产生的事物,药物临床试验在促进人类健康事业发展的同时,也涉及到与之相驳的伦理学问题,运用哲学的矛盾原理,浅析药物临床试验与医学伦理之间存在的矛盾及矛盾的两面性,以求解决目前药物临床试验中遇到的困难和问题。     

中西医结合治疗骨折的临床思维方法

骨科医生在骨折治疗中需要科学的方法论指导。系统论的思想应用于中西医结合治疗骨折,它能从人体的总体出发,在“动与静”、“筋与骨”、“内与外”、“人与物”四对矛盾的相互作用中,揭示损伤的性质和骨折愈合的规律,有助于获得骨折的最佳治疗原则,有助于提高认识水平和实践能力。     

外科手术决策过程中的情与法

越是给熟人、领导、要人做手术,出现各种手术相关问题的几率就越高。其原因主要是医生受各种情感因素的影响,降低了对医疗核心制度的执行标准,简化了术前准备,放宽了手术适应证,非理性地扩大了手术范围。解决方法:对待任何病人首先必须恪守法律和医疗规范,在此基础上尽可能与病人进行情感交流,达到医患共同自觉执行相关法律和规章,降低情感因素对手术决策的负性作用。