Cultural influences in somatosensory amplification and their association with negative affective states

Previous research has indicated that, reflecting East Asians’ holistic attentional style, they are likely to emphasize more somatic symptoms and perceive their internal visceral states less accurately as compared with Westerners. Based on these findings, comparing representative samples of Americans and Japanese participants, this research examined whether somatosensory amplification would vary across cultures. Moreover, by controlling confounding factors, including neuroticism and chronic disorders, the possibility that the association between somatosensory amplification and negative affective states differs across cultures also was tested. The results showed that Japanese exhibit higher somatosensory amplification than do Americans. In both cultures, as neuroticism and the number of chronic disorders increased, negative affective states also increased, leading to higher somatosensory amplification. Whereas negative affective states completely mediated the paths of neuroticism and chronic disorders to somatosensory amplification in the United States, such mediation was partial in Japan. Moreover, the association between somatosensory amplification and negative affective states was weaker in Japanese than in Americans.     

Is episodic memory performance more vulnerable to depressive affect in older adulthood?

This study examined how age, depressive symptoms, demographic variables, frailty, and health factors jointly influence episodic memory across the lifespan in two large, diverse samples. Hierarchical regression analyses from both samples showed that depressive symptoms negatively impacted episodic memory performance with the effect being more pronounced for older adults. Health and frailty tended not to be associated with episodic memory. However, the main effect of depressive symptoms tended to remain significant over and above other predictors, while the interaction with age was weakened with the addition of demographic variables. The unique contribution of this study is demonstrating that the relationship between depressive symptoms and episodic memory is moderated by age across relatively large non-clinical lifespan samples of adults. The findings indicate the importance of measuring and studying depressive symptoms during the course of aging in order to better understand the complex relationship between age, affect, physical functioning, and memory.     

Transgender Children and the Right to Transition: Medical Ethics When Parents Mean Well but Cause Harm

In this article, I argue that (1) transgender adolescents should have the legal right to access puberty-blocking treatment (PBT) without parental approval, and (2) the state has a role to play in publicizing information about gender dysphoria. Not only are transgender children harmed psychologically and physically via lack of access to PBT, but PBT is the established standard of care. Given that we generally think that parental authority should not go so far as to (1) severally and permanently harm a child and (2) prevent a child from access to standard physical care, then it follows that parental authority should not encompass denying gender-dysphoric children access to PBT. Moreover, transgender children without supportive parents cannot be helped without access to health care clinics and counseling to facilitate the transition. Hence there is an additional duty of the state to help facilitate sharing this information with vulnerable teens.     

Dangerous liaisons

In this paper I take side on externalist incompatibilism. However, I intend to radicalize the position. First, based on my criticism of Burge's anaphoric proposal, I argue that there is no reasoning‐transparency: the reasoner is blind to the reasoning he is performing. Second, assuming a global form of content‐externalism, I argue that “in the head” are only logical and formal abilities. That is what I call “bite the bullet and swallow it too.”     

‘It’s the unknown’ – understanding anxiety: from the perspective of people with multiple sclerosis

Objective: A qualitative study of PwMS who had clinically significant levels of anxiety was conducted to gain a richer perspective on their experience. The objective was to explore PwMS’ experiences of anxiety and their perspectives on causes and outcomes. Design: Twenty in-depth, semi-structured interviews were conducted with PwMS consecutively recruited from the Neurology Department of a NHS University Hospital. Sixteen had a relapsing-remitting course, three had a secondary progressive course and one person had primary progressive multiple sclerosis (MS). Interviews were recorded, transcribed and analysed using inductive thematic analysis. Results: Although participants thought different factors had initially triggered their anxiety, being given the diagnosis of MS appeared to be the most significant factor for many participants. Difficulties in the workplace and in relationships, particularly related to perceived dependence on others were also important themes. A wide range of emotional responses and negative thinking patterns were associated with anxiety; this suggested the presence of comorbid depression. Participants were able to acknowledge the positive and negative coping strategies that impacted on their anxiety. Conclusion: This review confirms that anxiety can have many negative implications for PwMS and suggests that early detection and intervention are necessary in order to improve patient’s well-being.     

Money does not bring well‐being,but it does help! The relationship between financial resources and life satisfaction of the chronically ill mediated by social deprivation and loneliness

Chronically ill people have lower incomes and higher illness‐related costs than the general population. Therefore, their financial situation can be considered vulnerable, like their health. The aims of this study were (1) to assess the strength of the relationship between financial resources and life satisfaction of patients with chronic physical illness and (2) to investigate the mediating roles of social deprivation and loneliness in this relationship. Data were used of 1265 patients diagnosed with one or more somatic chronic disease(s), aged 25 years and older, who were recruited from 56 general practices in The Netherlands. GPs provided data on diagnoses and illness duration; chronically ill patients provided data on their functional status, financial situation, social deprivation, loneliness and life satisfaction. Data were analysed by means of correlation and linear regression analyses as well as LISREL path analysis. Available income correlates 0.13 with life satisfaction, which is similar to correlations found in general Western populations. The effect of available income on life satisfaction is mainly an indirect effect that can be explained by the mediating roles of social deprivation and loneliness. Policy should pay specific attention to income support of the chronically ill and disabled in order to improve their opportunities for social participation and increase the quality of their life. Copyright © 2007 John Wiley & Sons, Ltd.     

疼痛恐惧的形成及其对疼痛知觉的影响

脑岛、杏仁核是疼痛恐惧形成的重要神经网络中心。疼痛恐惧增强了慢性疼痛患者的疼痛知觉体验, 进而加剧抑郁、焦虑情绪和功能损伤程度。脑岛、杏仁核、前额皮层和前扣带回是疼痛恐惧影响疼痛知觉的重要神经基础。通过认知方法干预疼痛恐惧可以改善患者的抑郁、焦虑情绪, 减少功能损伤。未来研究应拓展疼痛恐惧的测量工具, 采用功能磁共振成像技术进一步揭示疼痛恐惧影响慢性疼痛患者疼痛知觉的神经机制。     

创业失败与再创业意向的作用机制

近年来, 我国政府对创业支持力度不断加强, 创业活动日益活跃, 但失败率却居高不下。如何让创业者在遭遇失败后仍能保持再创业的意向是当前亟待解决的现实问题。拟综合采取横向问卷调查、纵向时间对比以及情景模拟实验的方法, 一方面探讨成就目标导向和社会比较在创业失败和创业失败学习之间的有中介的调节作用; 另一方面分析创业失败学习、创业自我效能感在创业失败和再创业意向之间的链式多重中介作用机制, 寻求由创业失败到再创业意向的不同路径, 这种探讨具有理论创新价值。依据实证研究的结论在实践中指导创业者通过上行比较, 锁定学习目标, 激发再创业意向; 通过提高自我怜悯水平, 使创业者摆脱消极情绪的困扰, 激发掌握性学习动机, 确立再创业的意向, 对于创业者具有重要指导意义。社会比较和自我怜悯的干预研究具有鲜明的中国文化特色。     

慢性应激损害大鼠学习记忆且抑制海马及额叶FGF2蛋白表达

慢性应激能够影响学习和记忆等认知功能。海马和额叶是与学习和记忆联系密切的脑区, 参与信息的获得、保持及提取。碱性成纤维生长因子(FGF2)对神经元发生、存活以及损伤修复具有重要促进作用, 目前成为神经系统退行性疾病相关研究的热点。本研究旨在探索慢性应激如何影响大鼠学习和记忆能力, 以及这一过程中FGF2蛋白在海马和额叶中表达的改变。实验中将16只雄性SD大鼠随机分为对照组和慢性应激组, 采用慢性不可预见温和刺激建立大鼠慢性应激模型, 通过Morris水迷宫实验及Y迷宫实验检测学习与记忆功能的改变, 并对海马及额叶中FGF2蛋白的表达情况进行Western blot及免疫组织化学检测。结果发现, 5周慢性应激导致大鼠学习和记忆能力受损, 海马及额叶FGF2蛋白表达下调。因此认为, FGF2蛋白可能参与慢性应激损害学习记忆能力的机制, 提示FGF2可能是诊断和治疗神经系统退行性病变的分子靶目标。