血液肿瘤的基因治疗及伦理学问题

基因治疗是一种新的有希望的抗肿瘤治疗方法。本文首先简述基因治疗发展史,然后介绍目前尝试性用于血液系统肿瘤的反义核酸疗法、抑癌基因疗法、自杀基因疗法以及过继性免疫疗法等基因治疗方法,进一步阐述基因治疗在血液系统肿瘤患者中应用存在的伦理学问题。     

小学教师对学生注意问题的知觉准确性研究

本研究以24名小学教师和98名小学生为研究对象,采用访谈法与测验法探讨了小学教师对学生注意问题的知觉准确性及其影响因素。结果表明:(1)从总体上看,小学教师对学生注意问题的知觉有着较高的准确性;(2)小学教师对学生注意问题的知觉准确性水平随教龄和职称的增高而呈下降趋势;(3)小学教师对学生注意问题的知觉准确性水平与其条件性知识掌握情况表现正相关;(4)小学教师对学生注意问题的知觉准确性与其所教年级无关。     

A conceptual metaphor framework for the teaching of mathematics

Word problems in mathematics seem to constantly pose learning difficulties for all kinds of students. Recent work in math education (for example, [Lakoff, G. &; Nuñez, R. E. (2000). Where mathematics comes from: How the embodied mind brings mathematics into being. New York: Basic Books]) suggests that the difficulties stem from an inability on the part of students to decipher the metaphorical properties of the language in which such problems are cast. A 2003 pilot study [Danesi, M. (2003a). Semiotica, 145, 71–83] confirmed this hypothesis in an anecdotal way. This paper reviews the implications of that study and of a follow-up one that is described here as well, in the light of how the metaphorical analysis of word problems allows learners to overcome typical difficulties in word problem-solving by teaching them how to flesh out the underlying concepts and convert them into appropriate representations.     

Treatment Participation among Children with Conduct Problems and the Role of Telephone Reminders

Children with antisocial, aggressive and disruptive behaviour problems are among the most frequent referrals to mental health services. These young people and their families present with a range of adverse contextual factors and can prove challenging to engage. We examined the characteristics of children with conduct problems, treatment participation, and the impact of telephone reminder calls. Consecutive referrals (N=262) to two child and youth mental health services were randomly assigned to either a reminder call condition or service as usual. In comparison to referrals without conduct problems, conduct problem children presented with greater sources of psychosocial adversity, attended fewer initial appointments and were at greater risk of treatment refusal. Importantly, telephone reminder calls significantly increased treatment attendance, though only for participants with elevated conduct problems. Telephone reminder calls, however, had no impact on treatment refusal, regardless of conduct problem status. The findings highlight a straightforward approach for enhancing treatment participation among a group that has been challenging for mental health services.     

Development and Validation of a Short Form of the Alabama Parenting Questionnaire

Brief assessments of parenting practices can provide important information about the development of disruptive behavior disorders in children. We examined the factor structure of a widely used assessment of parenting practices, the Alabama Parenting Questionnaire, and produced a 9-item short scale around its three supported factors: Positive Parenting, Inconsistent Discipline and Poor Supervision. The short scale was then validated in independent community samples using confirmatory factor analysis and measures of disruptive behavioral disorders in children. The scale showed good fit to a three-factor model and good convergent validity by differentiating parents of children with disruptive behavioral disorders and parents of children without such disorders. Results indicated that this new measure is an informative tool for researchers and clinicians whom require brief assessments of parenting practices relating to disruptive behavioral disorders in children.     

A model for predicting behavioural sleep problems in a random sample of Australian pre‐schoolers

Behavioural sleep problems (childhood insomnias) can cause distress for both parents and children. This paper reports a model describing predictors of high sleep problem scores in a representative population‐based random sample survey of non‐Aboriginal singleton children born in 1995 and 1996 (1085 girls and 1129 boys) in Western Australia. Longitudinal repeated data were collected up to age 4 years by caregiver report. Children's sleep rhythmicity levels in their first year, as well as conflicted and lax parenting in their second year, predicted higher scores on the sleep problem scale from the Child Behaviour Checklist/2–3 in the children's third year. Higher scores on the sleep problem scale in the children's third year predicted higher scores on the aggressive behaviour subscale of the Child Behaviour Checklist/4–16. The results support a model in which sleep problems mediated the relationship between parental conflict and aggressive behaviour, even when controlling for maternal depression, which has been associated with children's aggressive behaviour. Copyright © 2007 John Wiley & Sons, Ltd.     

The importance of narcissism in predicting proactive and reactive aggression in moderately to highly aggressive children

The present study examined the importance of psychopathy-linked narcissism in predicting proactive and reactive aggression and conduct problems in a group of 160 moderately to highly aggressive children (mean age of 10 years, 9 months). Children's self-report of self-esteem and parent and teacher report of dimensions of psychopathy [narcissism, callous-unemotional (CU) traits, and impulsivity], proactive and reactive aggression, and conduct problems were collected. Composites of parent and teacher ratings of children's behavior were used. Consistent with the study's hypotheses, narcissism predicted unique variance in both proactive and reactive aggression, even when controlling for other dimensions of psychopathy, demographic variables associated with narcissism, and the alternative subtype of aggression. As hypothesized, impulsivity was significantly associated with only reactive aggression. CU traits were not related to proactive or reactive aggression once the control variables were entered. All dimensions of psychopathy predicted unique variance in conduct problems. Consistent with prediction, narcissism was not significantly related to general self-esteem, providing support that narcissism and self-esteem are different constructs. Furthermore, narcissism and self-esteem related differentially to proactive aggression, reactive aggression, and conduct problems. Furthermore, narcissism but not self-esteem accounted for unique variance in aggression and conduct problems. The importance of narcissism in the prediction of aggressive behaviors and clinical implications are discussed.     

Action naming in anomic aphasic speakers: effects of instrumentality and name relation

Many studies reveal effects of verb type on verb retrieval, mainly in agrammatic aphasic speakers. In the current study, two factors that might play a role in action naming in anomic aphasic speakers were considered: the conceptual factor instrumentality and the lexical factor name relation to a noun. Instrumental verbs were shown to be better preserved than non-instrumental verbs in a group of anomic aphasic speakers but not in a group of Broca's aphasic speakers. Name relation to a noun improved the performance of the anomic aphasic speakers as well. Again, no effect was found in the group of Broca's aphasic speakers. Verbs with a name relation to a noun were better retrieved in action naming than verbs without a name relation. These findings are discussed in terms of the spreading activation theory of Dell. (Dell, G. S. (1986). A spreading activation theory of retrieval in sentence production. Psychological Review 93, 283-321.).     

Middle school student perceptions of school climate: Examining protective functions on subsequent adjustment problems

The present study examined the roles of student perceptions of four aspects of school climate (friction, cohesion, competition among students, and satisfaction with classes) as moderators of the relations between effortful control and subsequent conduct problems and depressive symptoms. Participants were 488 10-to-14-year old students involved in two waves, with one year between each wave, of a study. Hierarchical regression analyses indicated that high levels of perceived friction predicted more subsequent conduct problems and depressive symptoms, even after baseline levels of these problems were partialled out. Low levels of effortful control also elevated risk for subsequent conduct problems. However, perceptions of the school as high in cohesion offset the risk associated with low levels of effortful control. Perceived satisfaction with classes also offset this risk, but only for females. Contrary to expectations, student perceptions of school climate did not interact with effortful control to predict subsequent depressive symptoms.     

流动儿童社会适应的研究:现状、问题及解决办法

参照国外关于移民儿童社会适应研究的现状,对国内流动儿童社会适应的研究现状进行了回顾,指出了国内该研究领域存在的几个不足:(1)评估指标不全面;(2)评估存在缺陷取向;(3)忽视个体差异的问题;(4)研究设计与社会适应的过程理论相背离;(5)教育安置方式对流动儿童社会适应的影响未得到应有的重视。最后提出了解决以上问题的办法。