Effects of cocaine on performance under fixed-interval schedules with a small tandem ratio requirement

Daily administration of cocaine often results in the development of tolerance to its effects on responding maintained by fixed-ratio schedules. Such effects have been observed to be greater when the ratio value is small, whereas less or no tolerance has been observed at large ratio values. Similar schedule-parameter-dependent tolerance, however, has not been observed with fixed-interval schedules arranging comparable interreinforcement intervals. This experiment examined the possibility that differences in rate and temporal patterning between the two types of schedule are responsible for the differences in observed patterns of tolerance. Five pigeons were trained to key peck on a three-component multiple (tandem fixed-interval fixed-ratio) schedule. The interval values were 10, 30, and 120 s; the tandem ratio was held constant at five responses. Performance appeared more like that observed under fixed-ratio schedules than fixed-interval schedules. Effects of various doses of cocaine given weekly were then determined for each pigeon. A dose that reduced responding was administered prior to each session for 50 days. A reassessment of effects of the range of doses revealed tolerance. The degree of tolerance was similar across components of the multiple schedule. Next, the saline vehicle was administered prior to each session for 50 days to assess the persistence of tolerance. Tolerance diminished in all subjects. Overall, the results suggested that schedule-parameter-dependent tolerance does not depend on the temporal pattern of responding engendered by fixed-ratio schedules.     

Time and rate measures in choice transitions

Three experiments with pigeons studied the relation between time and rate measures of behavior under conditions of changing preference. Experiment 1 studied a concurrent chain schedule with random-interval initial links and fixed-interval terminal links; Experiment 2 studied a multiple chained random-interval fixed-interval schedule; and Experiment 3 studied simple concurrent random-interval random-interval schedules. In Experiment 1, and to a lesser extent in the other two experiments, session-average initial-link wait-time differences were linearly related to session-average response-rate differences. In Experiment 1, and to a lesser extent in Experiment 3, ratios of session-average initial-link wait times and response rates were related by a power function. The weaker relations between wait and response measures in Experiment 2 appear to be due to the absence of competition between responses. In Experiments 1 and 2, initial-link changes lagged behind terminal-link changes. These findings may have implications for the relations between fixed- and variable-interval procedures and suggest that more attention should be paid to temporal measures in studies of free-operant choice.     

Effects of reinforcer probability, delay, and response requirements on the choices of rats and pigeons: possible species differences

In Experiment 1 with rats, a left lever press led to a 5-s delay and then a possible reinforcer. A right lever press led to an adjusting delay and then a certain reinforcer. This delay was adjusted over trials to estimate an indifference point, or a delay at which the two alternatives were chosen about equally often. Indifference points increased as the probability of reinforcement for the left lever decreased. In some conditions with a 20% chance of food, a light above the left lever was lit during the 5-s delay on all trials, but in other conditions, the light was only lit on those trials that ended with food. Unlike previous results with pigeons, the presence or absence of the delay light on no-food trials had no effect on the rats' indifference points. In other conditions, the rats showed less preference for the 20% alternative when the time between trials was longer. In Experiment 2 with rats, fixed-interval schedules were used instead of simple delays, and the presence or absence of the fixed-interval requirement on no-food trials had no effect on the indifference points. In Experiment 3 with rats and Experiment 4 with pigeons, the animals chose between a fixed-ratio 8 schedule that led to food on 33% of the trials and an adjusting-ratio schedule with food on 100% of the trials. Surprisingly, the rats showed less preference for the 33% alternative in conditions in which the ratio requirement was omitted on no-food trials. For the pigeons, the presence or absence of the ratio requirement on no-food trials had little effect. The results suggest that there may be differences between rats and pigeons in how they respond in choice situations involving delayed and probabilistic reinforcers.     

Choice in a variable environment: effects of unequal reinforcer distributions

Six pigeons were trained in a procedure in which sessions included seven unsignaled components, each offering two pecking keys, and each providing a potentially different reinforcer ratio between the two keys. Across conditions, various combinations of reinforcer ratios and reinforcer-magnitude ratios were used to create unequal reinforcer distributions between the two alternatives when averaged across a session. The results extended previous research using the same basic procedure that had included only reinforcer distributions symmetrical around 1:1. Data analyses suggested that the variables controlling choice operated at a number of levels: First, individual reinforcers had local effects on choice; second, sequences of successive reinforcers obtained at the same alternative (continuations) had cumulative effects; and, third, when these sequences themselves occurred with greater frequency, their effects further cumulated. A reinforcer obtained at the other alternative following a sequence of continuations (a discontinuation) had a large effect and apparently reset choice to levels approximating the sessional reinforcer ratio.     

项目等距呈现过程中的系列位置效应

以中国汉字为材料,利用刘英茂提出的向前和向后联想的方法,证明在不同呈现时间和不同间隔时间条件下,系列位置曲线中首因效应和近因效应性质的分化过程。结果说明,系列位置曲线的近因部分对时间变化更为敏感,表现为绝对记忆的性质。系列位置曲线中首因效应和近因效应性质的分化,取决于项目呈现时间、项目间隔时间和系列包含的项目数。     

Tests of sphericity of normal distributions and the analysis of repeated measures designs

The locally best invariant test statistic for testing sphericity of normal distributions is shown to be a simple function of the Box/Geisser-Greenhouse degrees of freedom correction factor in a repeated measures design. Because of this relationship it provides a more intuitively appealing test of the necessary and sufficient conditions for valid F-tests in repeated measures analysis of variance than the likelihood ratio test. The properties of the two tests are compared and tables of the critical values of the Box/Geisser-Greenhouse correction factor are given.     

Concurrent ratio schedules: Fixed vs. variable response requirements

Rats were trained on concurrent fixed-ratio variable-ratio or concurrent fixed-ratio mixed-ratio schedules of food reinforcement. The variable-ratio schedule was composed of an arithmetic sequence of 11 ratios that averaged 50; the mixed-ratio schedule consisted of equiprobable ratios of 1 and 99. Fixed-ratio values, varied over experimental conditions, included 25, 35, 50, 60, and 99. The proportion of responses and time allocated to the variable- or mixed-ratio schedule increased as the size of the fixed ratio increased. For most subjects, higher proportions of responses and time were maintained on the fixed-ratio schedule at fixed-ratio values of 25 and 35; higher proportions of responses and time were maintained on the variable- or mixed-ratio schedule at fixed-ratio values of 50 or higher. On concurrent variable-ratio fixed-ratio schedules, the tendency for responding to be maintained exclusively by one schedule was related to the difference in local reinforcement rates obtained from those schedules. Exclusive responding was approximated when the difference in local reinforcement rates obtained from those schedules was large; responding was more evenly distributed between the schedules as the difference in the rates at which reinforcement was obtained from each decreased.     

Performance of rats under concurrent variable-interval schedules of negative reinforcement

The behavior of rats under concurrent variable-interval schedules of negative reinforcement was examined. A single one-minute variable-interval programmer determined the availability of 30-second timeouts from electric shock. These were assigned to one or the other of the two component schedules with a probability of 0 to 1.0. The response requirement for the component schedules was standing to the right or left of the center of the experimental chamber. With a six-second changeover delay, the relative time spent under one component schedule varied directly and linearly with the relative number of timeouts earned under that component schedule. The absolute number of changeovers was highest when a similar number of timeouts was earned under each component schedule, and lowest when all or nearly all timeouts were earned under one component schedule. In general, these relations are similar to those reported with concurrent variable-interval schedules of positive reinforcement.     

Local response-rate constancy on concurrent variable-interval schedules of reinforcement

Concurrent variable-interval schedules were arranged with a main key that alternated in color and schedule assignment, along with a changeover key on which a small fixed ratio was required to changeover. Acceptable matching was observed with pigeons in two replications, but there was a tendency toward overmatching. Local response rates were found to differ for unequal schedules of a concurrent pair: local response rate was greater for the variable-interval schedule with the smaller average interreinforcement interval, but qualifications based on an interresponse-time analysis were discussed. In a second experiment, two 3-minute variable-interval schedules were arranged concurrently, and the experimental variable was the changeover procedure: either a changeover delay was incurred by each changeover or a small fixed ratio on a changeover key was required to complete a changeover. Changeover delays of 2 and 5 seconds were compared with a fixed-ratio changeover of five responses. The response output on the main key (associated with the variable-interval schedules) was greater when a changeover delay was arranged than when a fixed ratio was required to changeover. A detailed analysis of stripchart records showed that a 2-second delay generated an increased response rate for 3 seconds after a changeover, while the fixed-ratio requirement generated an increased rate during the first second only, followed by a depressed response rate for 2 seconds.