IGFBP-2及IGFBP-6在结直肠癌中的表达及意义

研究胰岛素样生长因子结合蛋白2（IGFBP-2）及胰岛素样生长因子结合蛋白6（IGFBP-6）在结直肠癌中的表达及临床意义。采用免疫组织化学法及RT-PCR方法检测结直肠癌、结直肠腺瘤及癌旁正常黏膜组织中IGFBP-2及IGFBP-6的蛋白及mRNA的表达情况,结合临床病理资料进行统计学分析。IGFBP-2及IGFBP-6蛋白的阳性表达及mRNA的表达量在三组组织中均存在异常表达情况,且差异有明显的统计学意义（P〈0.05）,在结直肠癌组IGFBP-2、IGFBP-6的阳性表达在肿瘤浸润深度、有无淋巴结转移及Duke＇s分期存在差异,有明显的统计学差异（P〈0.05）。临床可以把二者作为结直肠癌诊断及预后的早期预测指标。     

Making Time Protestant in Early-Modern Glasgow

This article, drawn largely from the under-utilized Kirk session records from late-sixteenth-century Glasgow, by way of example, demonstrates how changing dispositions towards time were at the heart of the Reformation change of religion in Scotland. From the expansion of time obligations of Christians, the alteration of holy days, and the re-definition of basic units of time, alternative understandings of time were among the most tangible effects of the establishment of Protestantism in Scotland. In introducing time as a new way to examine the broad influence of the Reformation on the lives of the Scottish people, the article builds on recent research on the European Reformations while also introducing new perspectives on the uniqueness of the Scottish case.     

羞怯与受欺负:社交回避与被他人容纳的多重中介效应

采用大学生羞怯量表、被他人容纳量表、大学生社交回避及苦恼量表和欺负问卷测量了369名大学生,探讨社交回避和被他人容纳在羞怯与受欺负之间的作用。结果表明:(1)羞怯、社交回避和受欺负三个变量彼此之间均呈显著正相关,这三个变量与被他人容纳均呈显著负相关;(2)羞怯不仅直接影响受欺负,也通过社交回避-被他人容纳的链式中介作用间接影响受欺负。     

Cognitive diagnosis modelling incorporating item response times

To provide more refined diagnostic feedback with collateral information in item response times (RTs), this study proposed joint modelling of attributes and response speed using item responses and RTs simultaneously for cognitive diagnosis. For illustration, an extended deterministic input, noisy ‘and’ gate (DINA) model was proposed for joint modelling of responses and RTs. Model parameter estimation was explored using the Bayesian Markov chain Monte Carlo (MCMC) method. The PISA 2012 computer-based mathematics data were analysed first. These real data estimates were treated as true values in a subsequent simulation study. A follow-up simulation study with ideal testing conditions was conducted as well to further evaluate model parameter recovery. The results indicated that model parameters could be well recovered using the MCMC approach. Further, incorporating RTs into the DINA model would improve attribute and profile correct classification rates and result in more accurate and precise estimation of the model parameters.     

乡镇小学生的数学焦虑与数学成绩:数学自我效能感和数学元认知的链式中介作用

采用儿童数学焦虑量表、小学生数学学习自我效能感量表和小学生数学元认知问卷,对508名乡镇中、高年级小学生进行测量,并运用结构方程模型探讨数学焦虑影响数学成绩的内在作用机制。结果发现：（1）数学焦虑显著负向预测数学自我效能感、数学元认知和数学成绩,数学自我效能感显著正向预测数学元认知和数学成绩,数学元认知显著正向预测数学成绩;（2）在数学焦虑对数学成绩的预测中,数学自我效能感和数学元认知均发挥了部分中介作用;（3）数学自我效能感和数学元认知在数学焦虑和数学成绩之间起链式多重中介的作用。因此,数学焦虑除了直接作用于小学生的数学成绩,还可通过数学自我效能感或数学元认知间接影响数学成绩,而且可通过数学自我效能感进而通过数学元认知间接影响数学成绩。文章讨论了上述发现的理论及教育实践含义。     

抑郁在青少年核心自我评价与自杀意念间的中介作用:基于Bootstrap法和MCMC法的实证研究

考察抑郁在青少年核心自我评价与自杀意念间的中介作用。对502名高中生进行量表测评。通过偏差校正的Bootstrap法和有先验信息的MCMC法求出中介效应值的95%置信区间分别为[-.030,-.011]和[-.024,-.014],提示抑郁的中介效应显著。效应量k2、R2med分别为.124、.104,偏差校正的Bootstrap法抽样5000次后,构建的效应量的95%置信区间分别为[.070,.178]、[.063,.156],两种指标共同验证效应量为中等。研究结果说明抑郁在核心自我评价与自杀意念间起部分中介作用,效应量中等。     

Polytomous multilevel testlet models for testlet‐based assessments with complex sampling designs

A pplications of standard item response theory models assume local independence of items and persons. This paper presents polytomous multilevel testlet models for dual dependence due to item and person clustering in testlet‐based assessments with clustered samples. Simulation and survey data were analysed with a multilevel partial credit testlet model. This model was compared with three alternative models – a testlet partial credit model (PCM), multilevel PCM, and PCM – in terms of model parameter estimation. The results indicated that the deviance information criterion was the fit index that always correctly identified the true multilevel testlet model based on the quantified evidence in model selection, while the Akaike and Bayesian information criteria could not identify the true model. In general, the estimation model and the magnitude of item and person clustering impacted the estimation accuracy of ability parameters, while only the estimation model and the magnitude of item clustering affected the item parameter estimation accuracy. Furthermore, ignoring item clustering effects produced higher total errors in item parameter estimates but did not have much impact on the accuracy of ability parameter estimates, while ignoring person clustering effects yielded higher total errors in ability parameter estimates but did not have much effect on the accuracy of item parameter estimates. When both clustering effects were ignored in the PCM, item and ability parameter estimation accuracy was reduced.     

An investigation of differential reinforcement of alternative behavior without extinction

We manipulated relative reinforcement for problem behavior and appropriate behavior using differential reinforcement of alternative behavior (DRA) without an extinction component. Seven children with developmental disabilities participated. We manipulated duration (Experiment 1), quality (Experiment 2), delay (Experiment 3), or a combination of each (Experiment 4), such that reinforcement favored appropriate behavior rather than problem behavior even though problem behavior still produced reinforcement. Results of Experiments 1 to 3 showed that behavior was often sensitive to manipulations of duration, quality, and delay in isolation, but the largest and most consistent behavior change was observed when several dimensions of reinforcement were combined to favor appropriate behavior (Experiment 4). Results suggest strategies for reducing problem behavior and increasing appropriate behavior without extinction.