认知心理生理学与无创性脑功能成像技术

无创性脑功能成像技术是认知心理生理学研究的重要手段。脑电图、事件相关电位、脑磁图、正电子发射断层摄影术、单光子发射计算机断层摄影术、功能磁共振成像和功能红外线成像等技术通过对人脑的电磁、新陈代谢、血流量、氧消耗、神经元活动等的测量来研究如视觉、注意、记忆、语言等认知活动及其与相关脑机制的相互关系。它们各有优缺点。     

高血压脑出血微创治疗及手术时机的决策探讨

为了比较幕上高血压脑出血传统开颅与微创治疗的效果及其并发症,并对其手术时机进行探讨,对30例传统开颅组和104例微创治疗组进行对比研究。结果显示,术后6个月微创治疗组致残率及肺部感染发生率较传统开颅组明显为低(P0.05);早期(8h～24h)手术死亡率较超早期(8h)明显为低(P0.05)。因此,微创治疗能够有效降低高血压脑出血患者的致残率和术后并发症的发生率,其手术时机适宜选择在早期。     

脑动静脉畸形手术前后血流灌注的TCD研究

对脑AVM患者手术前后进行TCD检查以及激光多普勒监测,以探讨脑AVM患者血流动力学指标与手术后局部脑皮层血流量指标变化的相关性,从而为预测正常灌注压突破综合征提供依据。结果显示AVM患者高流量组与低流量组之间手术后rCBF值存在显著差异(P0.05),并且不同流量AVM供血动脉的血流动力学指标差异性于手术后消失。因此,通过对AVM患者手术前后TCD监测,有助于为预测术后局部脑皮层血流量变化提供依据。     

浅谈自发性脑出血诊断的辩证思维

自发性脑出血作为临床常见疾病,其背景复杂,对其予以准确诊断较为困难。除最常见于高血压性脑出血外,其既可作为某些疾病的首发表现,也可作为其他疾病的并发症或某些药物治疗的副作用而出现。其准确诊断除需具备完整临床知识结构外,亦要求我们具有辩证思维。本文旨在从辩证思维和临床角度探讨自发性脑出血的准确诊断。     

Effects of Visual Manipulation in Sit-to-Stand Movement in Children With Cerebral Palsy

The authors sought to verify the effects of vision on sit-to-stand (STS) movement performance by means of postural sway in children with cerebral palsy (CP) and typical children (TC). Participants were 42 TC and 21 children with CP. STS movement was assessed with eyes open and with eyes closed. Area and velocity of center of pressure sway were analyzed in each of the 3 STS phases. We observed greater postural sway during STS movement with eyes closed. Children with CP presented greater postural sway than TC did. Both groups exhibited greater postural instability with absence of vision expressing the role of vision to keep postural stability. Moreover, the greater postural instability was observed in children with CP.     

Implicit processing of emotional words by children with Post-Traumatic Stress Disorder: An fMRI investigation

Background/ObjectiveIn the last decade, socio-political violence in Colombia (South America) has created an environment of extreme/chronic stress. In this study, brain imaging technology (fMRI) and behavioral task performance were used to measure potential deficits in executive functioning for emotional processing in Colombian children.MethodParticipants (22 Post-Traumatic Stress Disorder, PTSD and 22 neurotypical, NT) were asked to perform a word task with implicit emotional salience, which required them to report the color of the ink in which a positive, negative or neutral word was printed.ResultsMixed design analysis of variance showed no group differences in accuracy for determining ink color when presented as a positive or neutral word. However, PTSD children were significantly less accurate (negative words) and notably slower (both positive and negative words) at determining ink color when presented in the context of an emotional word. PTSD processing of positive and negative words was associated with hypoactivation in the superior and middle frontal gyri of the right hemisphere in comparison to NT children.ConclusionsThese results may reflect a deficit in executive functioning for emotionally laden stimuli, perhaps induced as a by-product of their traumatic experiences.     

右侧脑发育不全患者启动效应与智力水平分离

采用 ＷＭＳ－ＣＲ． ＷＩＳＣ－ＣＲ和４项内隐记忆任务（偏好、自由联想、字根补笔和字辨认）观察一例右侧脑发育不全患者和两正常对照组被试的智商、记忆商和启动效应。发现该患者智力发育迟滞、记忆功能严重损伤,但启动效应正常。提示右侧脑发育不全患者启动效应与智力测验结果分离。由于启动效应是人类的一种重要的无意识习得能力,因此该研究表明智力发育迟滞者或脑损伤患者仍可能存在较好的无意识习得能力,这对特殊教育和临床脑损伤患者康复有一定的参考价值;同时该研究提示当前智力测验未能反映大脑功能的无意识方面,提出今后的智力测验应包括无意识习得能力的测量。     

右侧脑发育不全遗忘症患者的启动效应与右侧皮层的分离

采用ＷＭＳ－ＣＲ、ＷＩＳＣ－ＣＲ和４项内隐记忆任务（偏好、自由联想、字根补笔和字辨认）观察一例右侧大脑发育不全患者和两组正常对照的知觉性启动效应和语义性启动效应。发现该患者智力发育迟滞、记忆功能严重障碍,但两种启动效应正常。显示右侧大脑皮层发育不全不影响两种启动效应任务操作,启动效应与右侧大脑皮层分离。不支持Ｋｅａｎｅ等人认为知觉性启动效应的神经学基础在大脑皮层的结论。结合先的研究结果认为知觉性启动效应可能与基底神经节有关,语义性启动效应可能与左侧大脑皮层有关。     

Visual attention skills of premature infants with and without intraventricular hemorrhage

The relation between two medical complications associated with prematurity (intraventricular hemorrhage (IVH) and respiratory distress syndrome (RDS)) and visual attention skills of very low birth-weight (VLBW) infants were examined. Fourteen preterm VLBW infants with IVH and RDS, 9 preterms with RDS and no IVH, and 10 full-term infants matched on SES, sex, and race were assessed at 7 months of age (after correction for prematurity) for their ability to show a decremental response to a familiar visual stimulus and an increment in response to a novel visual stimulus. Measures of attention getting (turning toward a stimulus) and attention holding (sustained fixation on the stimulus after turning) were taken. On the attention-getting measures, IVH-RDS preterms had longer latencies than both the RDS-no-IVH preterm group and the full-term group. There were no group differences on attention-holding measures. The three groups did not differ in habituation to the familiar visual stimulus or discrimination of the novel stimulus. This study indicates that the early visual attention skills of preterm infants are differentially affected by specific types of prenatal complications.     

阿拉伯数字与汉字大写数字认知的大脑功能一侧化实验研究

用半视野速示术检查阿拉伯数字和汉字大写数字在三种任务加工条件（认读、简单相加、奇偶概念异同判断）下进行认知的大脑两半球机能活动一侧化效应。结果表明：以被试正确反应的百分数为指标,两类数字的三种任务加工均没有表现出明显的视野（大脑半球）优势。以被试正确反应的反应时为指标,两类数字的认读和简单相加也未出现视野（大脑半球）的明显差别,而两类数字的奇偶概念异同判断却出现了差异显著的右视野（左半球）优势。