过度担忧和广泛性焦虑障碍与rCBF关系的SPECT脑显像研究

目的：探查过度担忧者和GAD病人的r CBF变化,更好地了解导致病理性焦虑和GAD的神经病理生理学基础。方法：回顾性分析18例过度担忧者和61例GAD病人SPECT脑显像的结果。GAD患者再按病程分为3个亚组。计算各组患者特定脑区r CBF损伤的百分比及损伤的脑区数。结果：12例（66.7%）过度担忧者可见前额叶、基底节、扣带回、颞叶和枕叶r CBF增加（11例）和/或减少（9例）。58例（95.1%）GAD患者可见r CBF减少,主要累及中和下前额叶、中和下颞叶、前扣带、海马旁回、基底节和丘脑。大多数GAD患者累及的主要脑区等于或大于3个。GAD病人的r CBF损伤和病程之间存在一定的相关性。结论：结果支持GAD患者r CBF的变化是一个与担忧和焦虑等心理和情绪改变密切相关的慢性和渐进的过程。GAD的局部脑功能障碍是病理性焦虑产生的先决条件,并出现在局部脑结构异常之前。     

Effects of Visual Manipulation in Sit-to-Stand Movement in Children With Cerebral Palsy

The authors sought to verify the effects of vision on sit-to-stand (STS) movement performance by means of postural sway in children with cerebral palsy (CP) and typical children (TC). Participants were 42 TC and 21 children with CP. STS movement was assessed with eyes open and with eyes closed. Area and velocity of center of pressure sway were analyzed in each of the 3 STS phases. We observed greater postural sway during STS movement with eyes closed. Children with CP presented greater postural sway than TC did. Both groups exhibited greater postural instability with absence of vision expressing the role of vision to keep postural stability. Moreover, the greater postural instability was observed in children with CP.     

语篇主题表征在大脑两半球的存贮

使用半视野速示技术和启动—再认探测方法,采用包含两个句子的短语篇作为前行信息、通过主题启动、歧义词启动探测语段阅读时主题表征在大脑两半球的存贮情况,结果发现,无论是主题启动还是歧义词启动,左视野／右半脑和右视野／左半脑对语境相关的目标词反应时间都比不一致目标词更长,说明语段阅读后两半脑对主题表征都有存贮。     

脑动静脉畸形手术前后血流灌注的TCD研究

对脑AVM患者手术前后进行TCD检查以及激光多普勒监测,以探讨脑AVM患者血流动力学指标与手术后局部脑皮层血流量指标变化的相关性,从而为预测正常灌注压突破综合征提供依据。结果显示AVM患者高流量组与低流量组之间手术后rCBF值存在显著差异(P0.05),并且不同流量AVM供血动脉的血流动力学指标差异性于手术后消失。因此,通过对AVM患者手术前后TCD监测,有助于为预测术后局部脑皮层血流量变化提供依据。     

¿Qué es una emoción?

RESUMEN

La finalidad de estas páginas es mostrar que, en lo que respeta a las emociones, los procesos cerebrales emocionales no sólo se asemejan a los procesos cerebrales sensoriales comunes, sino que, en términos estructurales, no son sino todos los mismos procesos combinados de distinta forma. El resultado más importante de ello será simplificar nuestras nociones sobre los posibles complicaciones fisiológicas del cerebro y hacernos ver que poseemos ya un modelo de cerebro cuyas aplicaciones son mucho más amplias de lo que creían algunos autores. La tesis principal es que los cambios corporales que siguen directamente a la percepción del hecho desencadenante y nuestra sensación de esos cambios según se van produciendo es la emoción.     

Early and middle childhood developmental,cognitive, and psychiatric outcomes of Malawian children affected by retinopathy positive cerebral malaria

The objective is to determine the short -and long-term developmental, cognitive, and psychiatric effects of retinopathy positive cerebral malaria (CM-R) among young children in a prospective study assessing them around the onset of disease and again 2 years at preschool and again at school age.

In total, 109 children were recruited from the Queen Elizabeth Central Hospital in Blantyre, Malawi, (N = 49) with CM-R and non-malaria controls (N = 60). Children were assessed for overall motor, language, and social skills using the Malawi Developmental Assessment Tool (MDAT) at preschool age. At school age, the same children were then given the Kaufman Assessment Battery for Children, second edition (KABC-II), which assessed global cognitive performancememory, and learning; as well as the Test of Variables of Attention (TOVA), which assessed attention. The Achenbach Child Development Checklist (CBCL) was administered at both time points to assess emotional and behavioral patterns.

Controls scored significantly better on all KABC-II global domains as well as on the mental processing index than their CM-R group counterparts, but showed no performance differences in the TOVA and CBCL assessments at school age, or in the MDAT and CBCL assessments at preschool age. The MDAT total score was significantly correlated with the KABC-II sequential processing, learning, and mental processing index among CM-R survivors but not among controls.

Persisting neurocognitive effects of CM can be captured with the KABC-II at school age. The MDAT at preschool age is correlated with the KABC-II among CM-R survivors and can be used to capture early emerging developmental deficits due to CM-R.