Neurochemical mechanisms underlying amygdaloid modulation of aggressive behavior in the cat

Studies designed to determine the respective roles of substance P, excitatory amino acids, and enkephalins in amygdaloid modulation of defensive rage behavior in the cat are presented. The basic design of these studies involved three stages. In stage I, cannula electrodes for stimulation and drug infusion were implanted into medial hypothalamic or midbrain periaqueductal gray (PAG) sites from which defensive rage behavior could be elicited. Then, a stimulating electrode was implanted into a site within the medial, basal, or central nuclear complex from which modulation of the defensive rage response could be obtained. Amygdaloid modulation of defensive rage was determined in the following manner: it employed the paradigm of dual stimulation in which comparisons were made of response latencies between alternate trials of dual (i. e., amygdala = medial hypothalamus [or PAG]) and single stimulation of the hypothalamus or PAG alone. Thus, stage I established the baseline level ofmodulation (i. e., facilitation or suppression of defensive rage) in the predrug stimulation period. In stage II, a selective or nonselective receptor antagonist for a given transmitter system was administered either peripherally or intracerebrally at the defensive rage site, after which time the same dual stimulation paradigm was then repeated over the ensuing 180 min postinjection period in order to determine the effects of drug delivery upon amygdaloid modulation of defensive rage. Stage III of the study took place at the completion of the pharmacological testing phase. The retrograde axonal tracer, Fluoro-Gold, was microinjected into the defensive rage site within the medial hypothalamus or PAG, and following a 6-14 day survival period, animals were sacrificed and brains were processed for histological and immunocytochemical analyses for the neurotransmitters noted above. This procedure thus permitted identification of cells within the amygdala which were labeled retrogradely and which were also immunostained positively for substance P, excitatory amino acids, or enkephalin. For studies involving substance P, defensive rage was elicited from the medial hypothalamus and for studies examining the roles of excitatory amino acids and enkephalin, defensive rage was elicited from the PAG. In the first study, facilitation of hypothalamically elicited defensive rage was obtained with dual stimulation of the medial nucleus of the amygdala. In separate experiments, the selective NK₁ non-peptide antagonist, CP 96,345, was administered both peripherally as well as intracerebrally into the hypothalamic defensive rage sites in doses of 0.5-4.0 mg/kg (i. p.) and 0.5-2.5 nmol (i. c.). Following drug delivery, the facilitatory effects of medial amygdaloid stimulation were blocked in a dose- and time-dependent manner in which the effects were noted as early as 5 min postinjection. The maximum drug dose (4.0 mg/kg) employed for peripheral administration resulted in a 42% reduction in the facilitatory effects of the medical amygdala (P < 0.002). This drug, when microinjected directly into medial hypothalamic defensive rage sites at the maximum dose level of 2.5 nmol, resulted in an 84% reduction of the suppressive effects of amygdaloid stimulation (P < 0.5) at 5 min postinjection. In the next study, an N-methyl-D-aspartate (NMDA) antagonist, DL-α-amino-7-phosphonoheptanoic acid (AP-7), was administered either peripherally (0.1-1.0 mg/kg) or intracerebrally (0.2 and 2.0 nmol) into PAG defensive rage sites. Facilitation of defensive rage behavior, which was observed following dual stimulation of the basal amygdala and PAG, was significantly reduced by either route of drug administration in a dose- and time-dependent manner. At the maximum dose level of peripheral administration, AP-7 reduced amygdaloid facilitation of defensive rage by 63% (P < 0.001) for 60 min, postinjection. A smaller (i. e., 19%) but still significant (P < 0.05) reduction in facilitation was obtained following intracerebral administration of the drug. In a third study, the non-selective opioid receptor antagonist, naloxone (27.5 nmol), infused directly into PAG defensive rage sites, totally blocked the suppressive effects of central amygdaloid stimulation for a period of 30 min (P < 0.05) in a dose- and time-dependent manner. The anatomical phase of this study revealed the following relationships: 1) that large numbers of neurons projecting to the medial hypothalamus from the medial amygdala immunoreact positively for substance P; 2) that neurons projecting to the PAG from the basal complex of amygdala immunoreact positively for glutamate and aspartate; and 3) that neurons located within the central nucleus of the amygdala which project to the PAG immunoreact positively for met-enkephalin. Collectively, these observations provide new evidence which characterizes the likely neurotransmitters linked with specific amygdaloid pathways subserving the modulation of defensive rage behavior in the cat.     

Effets comportementaux et cognitifs de l'engagement dans un acte préparatoire activant un élément central versus périphérique de la représentation du don d'organes

We render an account of a research programme that links two fields of study usually unconnected: the field of the freely agreed submission and the field of social representations. Two hypothesis are tested in the foot-in-the door paradigm: participants that agree to perform an initial request (to sign a petition) that selects a core element of the representation of organ donation: a) will be more inclined to agree to perform the target request (to sign a donor card); and b) will have an attitude more favourable about organ donation than participants that agree to perform an initial request that selects a peripheral element. The two experiments presented confirm these hypotheses.     

数学学习困难与工作记忆关系研究的现状与前瞻

工作记忆是一种对信息进行暂时加工和贮存的能量有限的记忆系统,在许多复杂的认知活动中起重要作用,工作记忆缺陷是造成数学学习困难的根本原因。数学学习困难儿童都存在视觉空间模板、语音回路以及中央执行器功能等方面的缺陷,工作记忆的各成分对数学困难者的影响不同。今后研究将以整体的、发展的视角,不断改进研究方法,将行为研究和神经加工机制研究相结合。     

工作记忆中央执行功能的特异性和可分离性

采用3种中央执行功能,对中央执行功能的特异性和可分离性进行研究。选取青年和老年被试各31名。每位被试都要参加3种中央执行功能2个难度水平的任务和瑞文标准推理测验。结果发现：记忆刷新的年龄效应不能完全由液态智力的年龄差异来解释;虽然同种执行功能内不同难度任务的年龄效应类似,但不同执行功能的年龄效应不同,从大到小依次为记忆刷新、随机生成和选择性注意;控制液态智力的影响后,同种执行功能内不同难度任务间的相关仍然显著,而不同中央执行功能之间的相关不显著;另外,本实验条件下选择性注意与液态智力相关不显著,且不存在年老化现象。研究结果表明中央执行功能相对于液态智力具有一定的特异性,并且可以进一步分离为一些相互独立的子功能。     

语音记忆和中央执行功能在不同年级儿童解码和语言理解中的作用

选取256名三~六年级儿童, 采用相关分析、结构方程模型等方法考察了语音记忆和中央执行功能在不同年级儿童的解码和语言理解中的作用。结果显示, 在低年级阶段, 语音记忆和刷新对解码存在显著预测作用, 转换和刷新对语言理解存在显著预测作用; 在高年级阶段, 只有刷新对解码保持着稳定的预测作用。这表明, 语音记忆和中央执行功能对儿童的解码和语言理解存在不同的影响, 并且这种影响会随着年级的增长发生变化。     

Attentional Limitations in Doing Two Tasks at Once

ABSTRACT— People generally have difficulty doing two tasks at once. To explain this fact, theorists have proposed that central processing—the thought-like stages following perceptual encoding and preceding response processing—takes place for only one task at a time. Because this bottleneck imposes severe limits on human cognitive processes, research has attempted to find exceptions. There is now solid evidence that, at least in the laboratory, the entire bottleneck can be completely bypassed under favorable combinations of circumstances. While these findings provide a ray of hope for enabling parallel multitasking in real-world scenarios, it will not be easy to take advantage of the combination of conditions that appear to be necessary.     

自闭症儿童的中心信息整合及其与心理理论的关系

研究用积木测验和镶嵌图形测验测量中心信息整合,用5个信念任务测量心理理论能力,比较了12名自闭症儿童和同等言语能力的28名正常儿童的表现,并分析了心理理论和中心信息整合的相关。结果表明:(1)中心信息整合的测量指标积木测验和镶嵌图形测验成绩保持中高度相关;(2)自闭症儿童中心信息整合显著弱于正常儿童;(3)心理理论和中心信息整合成绩相互独立。     

易学视域下的象山心学

象山心学有着深层易学根基之支撑。基于易学的天人之学,他敞开了以大中至正之道、之理为根基根据的整体宇宙图景。认为人的本心存在的敞开着宇宙大千世界中的一切。《易》的"穷理尽性以至于命"的价值期许,遂具体落实为人人之开显对于本心的高度明觉,挺立个我生命的主体性,积极构建基于此心的属于自己的意义的世界。     

心理病理学网络理论、方法与挑战

对于精神障碍这一概念的理解, 传统DSM-ICD分类诊断系统和研究领域标准RDoC均基于潜变量视角, 认为精神障碍的症状由其潜在共同原因所致。这2种观点都忽略了症状间的相互作用。不同于分类和维度视角, Borsboom在2008年对精神障碍的概念化提出了的全新视角——心理病理学网络理论。此理论的核心观点是症状之间的动态因果关系构成了精神障碍。基于心理病理学网络理论的网络分析方法, 主要以结合EBIC的glasso算法估计症状间的偏相关网络, 并通过网络中节点中心性与网络连接性等指标, 来考查精神障碍症状的不同特性。近几年来, 研究者发现心理病理学网络分析方法在对症状间因果关系的推断、核心症状的识别和网络结构的可靠性与可重复性方面仍面临一些挑战。这些挑战为心理病理学网络理论与方法指明了未来可能的发展方向。     

习得性无助是习得的吗？——对习得性无助理论及其反思的评述

Seligman和Maier（1967）在动物实验的基础上提出了著名的习得性无助理论,但在2016年,Maier和Seligman二人却联合发文对该理论进行了反思：从最新的神经生物学证据来看,习得性无助的经典理论概括存在基本错误,习得性无助并非习得而来！所谓“习得性”无助,实质上是动物对厌恶刺激长期作用的先天适应性反应,而非认知学习的结果。本文简要梳理习得性无助理论的起源与发展,深入分析这一反思的核心内容、依据及意义,对其中否定习得性无助理论概括的观点,从证据的充分性、研究范式的效度、规范概念等角度作了进行进一步的探讨,并结合新的实验范式对未来研究提出建议。