Environmental and Behavioral Influences on Gene Activity

The central dogma of molecular biology holds that 'information' flows from the genes to the structure of the proteins that the genes bring about through the formula DNA → RNA → protein. In this view, a set of master genes activates the DNA necessary to produce the appropriate proteins that the organism needs during development. In contrast to this view, probabilistic epigenesis holds that necessarily there are signals from the internal and external environment that activate DNA to produce the appropriate proteins. To support this view, I review a substantial body of evidence showing that external environmental influences on gene activation are normally occurring events in a large variety of organisms, including humans. This demonstrates how genes and environments work together to produce functional organisms, thus extending the model of probabilistic epigenesis.     

An Archival Study of Eyewitness Memory of the Titanic's Final Plunge

A handful of real-life studies demonstrate that most eyewitnesses accurately recall central details (i.e., the gist of what happened) from traumatic events. The authors evaluated the accuracy of archival eyewitness testimony from survivors of the Titanic disaster who witnessed the ship's final plunge. The results indicate that most eyewitness testimony (15 eyewitnesses of 20) is consistent with forensic evidence that demonstrates that the Titanic was breaking apart while it was still on the ocean's surface. Despite the methodological limitations of archival research, the authors provide evidence from a single-occurrence traumatic event (with a large-scale loss of life) that the majority of eyewitnesses accurately recall central details.     

301例中枢神经系统感染的临床分析

回顾性研究301例中枢神经系统感染病例的临床资料,分析其临床特点,将符合临床诊断标准的病例按病原种类分为病脑组、结脑组、化脑组及隐脑组4个组,应用相关的统计描述分析其临床特征。结果发现病毒性脑（膜）炎是最常见的中枢神经系统感染性疾病,而中枢神经系统感染性疾病一年四季均可发病,其中病毒性脑（膜）炎高发于5月及7月,结核性脑膜炎则高发于1月与3月,有明显的季节性。中枢神经系统感染的临床首发症状依次表现为发热、头痛、意识障碍、精神症状、抽搐及神经系统定位症状。     

Reduced interhemispheric interaction in non-autistic individuals with normal but high levels of autism traits

People with autism spectrum disorder (ASD) show superior performance for tasks requiring detail-focused processing. Atypical neural connectivity and reduced interhemispheric communication are posited to underlie this cognitive advantage. Given recent conceptualization of autism as a continuum, we sought to investigate whether people with normal but high levels of autism like traits (AQ) also exhibit reduced hemispheric interaction. Sixty right-handed participants completed the AQ questionnaire (Baron-Cohen, Wheelwright, Skinner, Martin, & Clubley, 2001) and a lateralised letter matching task that assessed unilateral and bilateral performance in response to simple (physical) and complex (identity) matches. Whereas people with low self-rated AQ scores showed a bilateral advantage for the more complex task, indicating normal interhemispheric interaction, people in the high AQ group failed to show a bilateral gain for the computationally demanding stimuli. This finding of disrupted interhemispheric interaction converges with a dimensional conceptualisation of ASD, suggesting that the structural anomalies of ASD extend to non-autistic individuals with high levels of autism traits.     

Neuropsicología clínica: Revisión y previsión

RESUMEN

Este trabajo presenta las contribuciones originarias, actuales y potenciales de la neuropsicología clínica, defendiendo que no sólo ayuda a la comprensión de los problemas de la relación entre mente y cerebro sino que puede revolucionar el tratamiento de los pacientes que sufren diversas disfunciones del sistema nervioso superior, debido a sus implicaciones terapéuticas. Respecto a sus contribuciones actuales se destacan, entre otras, la de proporcionar medidas objetivas de la significación funcional de una lesión y líneas base para evaluar los efectos a largo plazo o el curso de rehabilitación, revisando las técnicas y resultados de varias investigaciones que exploran las funciones de estructuras corticales y subcorticales. Como contribución potencial se señala la posibilidad de reinstaurar las funciones cerebrales y de acelerar el ritmo de compensación de lesiones, diseñando programas de rehabilitación específicos para cada paciente que estén basados en la medición neuropsicológica, en estrecha colaboración con otros profesionales. Este trabajo finaliza concluyendo que la neuropsicología clínica puede constituir el foco del tratamiento interdisciplinario de los pacientes con alteraciones del sistema nervioso central.     

数学学习困难初中生的中央执行系统特点

为揭示数学学习困难学生的认知过程加工特点,筛选上海111名初中生（男生46名,女生68名,平均年龄11.97岁）比较数学困难学生（55名）与数学优秀学生（56名）的中央执行系统的表现差异,通过反应停止任务和Flanker任务考察抑制能力以及注意控制能力。结果发现各种抑制和注意控制条件下,数困组学生的正确率低于数优组;在具有干扰的情况的成绩更能有效预测数学成绩;中央执行系统能力在初中总体具有上升发展趋势,数困生的发展具有波动性。因此,数学学习困难在中央执行系统中的缺损主要是对抗干扰的能力不足,而非简单的加工速度。     

叙述文本中中心概念的确定方式及其通达

采用移动窗口技术考察叙述文本中中心概念的确定方式及其通达。实验一在中文条件下得出了与Michelle＆O’Brien2002研究一致的结果。实验二采用事件相关方式确定中心词．结果表明．无论在标题相关陪衬调还是在事件相关陪衬调干扰下。事件相关中心词通达效果显著优于边缘词。实验兰进一步比较事件相关中心概念与词频相关中心概念的通达效果。结果表明,前者通达效果显著优于后者。总的实验结果表明。事件相关中心的确定方式同样在叙述文本中具有适用性．能够很好地体现文本中心,表现出情境模型水平上的通达优势。     

工作记忆中央执行对儿童算术认知策略的影响

运用“双重任务”范式,以113名小学二年级儿童为被试,考察了儿童工作记忆的中央执行对算术认知策略表现的影响。结果表明:中央执行对儿童算术认知策略的选择产生了针对性的影响,集中表现在外部策略、支持性策略和猜测放弃策略上。中央执行干扰使策略执行的正确率下降、反应时增加。在简单加法任务上,中央执行影响了外部策略和支持性策略的选择频次;在复杂任务中,这种影响体现在外部策略和放弃策略上。无论是简单任务还是复杂任务,中央执行的干扰都造成了策略整体执行效果的下降。     

Movement segmentation and visual perturbation increase developmental differences in motor control and learning

We examined the developmental differences in motor control and learning of a two‐segment movement. One hundred and five participants (53 female) were divided into three age groups (7–8 years, 9–10 years and 19–27 years). They performed a two‐segment movement task in four conditions (full vision, fully disturbed vision, disturbed vision in the first movement segment and disturbed vision in the second movement segment). The results for movement accuracy and overall movement time show that children, especially younger children, are more susceptible to visual perturbations than adults. The adults’ movement time in one of the movement segments could be increased by disturbing the vision of the other movement segment. The children's movement time for the second movement segment increased when their vision of the first movement segment was disturbed. Disturbing the vision of the first movement segment decreased the percentage of central control of the second movement in younger children, but not in the other two age groups. The children's normalized jerk was more easily increased by visual perturbations. The children showed greater improvement after practice in the conditions of partial vision disturbance. As the participants’ age increased, practice tended to improve their feedforward motor control rather than their feedback motor control. These results suggest that children's central movement control improves with age and practice. We discuss the theoretical implications and practical significance of the differential effects of visual perturbation and movement segmentation upon motor control and learning from a developmental viewpoint.     

Neuropsychological Sequelae of Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease: A Critical Review

Neuropsychologists are increasingly involved in surgical candidacy evaluations and postoperative neurobehavioral assessments of patients with movement disorders, most notably those with disease (PD). We review here the initial studies regarding neuropsychological outcomes of deep brain stimulation (DBS) within the subthalamic nucleus (STN) for treatment of PD. Overall, these initial investigations provide preliminary support for the cognitive and neurobehavioral safety of STN DBS. Improvements in self-reported symptoms of depression and diminished verbal fluency were the most common findings, whereas changes in global cognitive abilities, memory, attention, and frontal/executive functions were inconsistent and most often described as nominal and/or transient. The generalizability of this literature is hindered by several methodological limitations, including small samples and the absence of appropriate control participants. The clinical and theoretical implications of these initial studies are highlighted and recommendations are offered to guide future research.