Differential interaction of platelet-activating factor and NMDA receptor function in hippocampal and dorsal striatal memory processes

The interaction between platelet activating factor (PAF) and NMDA receptor function in hippocampal and dorsal striatal memory processes was examined. In both a hidden and a visible platform water maze task, peripheral post-training injection of MK-801 (0.05 mg/kg) impaired memory. Post-training intrahippocampal infusions of PAF (1.0 microg/0.5 microl) enhanced memory in the hidden platform task, while intradorsal striatal infusion of PAF (1.0 microg/0.5 microl) enhanced memory in the visible platform task. The memory impairing effects of post-training injection of MK-801 was blocked by concurrent intrahippocampal infusion of PAF. In contrast, post-training injection of MK-801 blocked the memory enhancing effects of concurrent intradorsal striatal infusion of PAF. The results suggest that (1) the memory enhancing effects of intracerebral PAF infusion involve an interaction with NMDA receptor function, and (2) the nature of this interaction may represent a differential mechanism mediating the distinct roles of the hippocampus and dorsal striatum in cognitive memory and stimulus-response habit formation, respectively.     

Centrality ratings,forensic relevance,and production frequency: Which one best identifies central and peripheral items?

Production frequency has often been used to identify central and peripheral information, under the assumption that high frequency implies that the item is central. However, no research to date has tested the relationship between centrality and frequency. Participants watched a video of a bank robbery and completed a free recall test, from which frequency for recalled items was computed. Two groups then watched the same video and rated centrality and forensic relevance for each item. Results showed that most, but not all, items with high frequency were rated as central and forensically relevant but that low frequency items were not diagnostic of either item centrality or forensic relevance. Forensic relevance was a better indicator of item centrality than frequency. We concluded that frequency measures should be avoided to determine centrality. Also, if centrality ratings cannot be collected, forensic relevance ratings may be more appropriate for this purpose.     

Good writers,bad Jews: the “Jewish Question” among Hungarian Jewish intellectuals of the interwar period

This paper investigates the perceived place of the Jewish writer in interwar Hungarian Jewish literature. Post-World War I Hungary suffered from the effects of a short-lived communist regime, and the Trianon Treaty by losing two-thirds of its territories and more than half of its population. Though previously Jewish communities had thrived in the country, these events caused resentment that manifested itself in the creation of anti-Semitic laws in 1920. Within this new context, assimilated liberal young Jewish writers posed the question of “what is a Jew,” reflecting on their Jewishness and Hungarianness at the same time and pondering about the value of each. They answered the question in their creative works, where they indirectly explored issues such as whether Jews are able to write Hungarian novels or whether only a Hungarian can do so; whether Jewish Hungarians could write Hungarian Jewish novels; whether Hungarianness and Jewishness are compatible or whether writing literature is preconditioned on identity. Through the lens of Aladár Komlós, this paper examines the way in which liberal and assimilated young Hungarian Jewish writers interpreted their place in Hungarian culture and society within the framework of these questions.     

Projection of the Magnocellular Red Nucleus to the Region of the Accessory Abducens Nucleus in the Rabbit

The projection of the magnocellular red nucleus (RNm) to the region of the accessory abducens nucleus (AABD) was traced in rabbit using the bidirectional tracer wheat germ agglutinin-horseradish peroxidase (WGA-HRP). In one set of animals, recordings of antidromic responses from RNm neurons elicited by electrical stimulation of the rubrospinal tract were used to localize injections of WGA-HRP for orthograde labeling of RNm terminals. In a different set of animals, horseradish peroxidase was injected into the retractor bulbi muscle to retrogradely label motoneurons of the AABD. The positions of RNm fibers and terminals were examined and compared to the locations and distribution of AABD cell bodies and labeled dendrites. Analyses revealed that along the entire rostrocaudal extent of the AABD, RNm efferents terminate primarily lateral to, or in the lateral aspects of, labeled motoneurons. For the rostral AABD, RNm efferents terminate only lateral to the nucleus. Although the terminals are not positioned to contact cell bodies of the AABD, they could overlap with dendrites that extend in the lateral direction. RNm efferents terminate more extensively within the posterior AABD, overlapping within both dendritic and cell body regions of the nucleus. Even in this posterior region, however, RNm efferents were distributed primarily over the lateral half of the nucleus. These data show that RNm can monosynaptically influence the AABD, through primarily its lateral and posterior aspects. Our findings also show that a major target of RNm efferents is the reticular cell population located lateral to the AABD, suggesting that the RNm also may affect AABD motoneuronal output indirectly through its projection to reticular cells.     

Efficacy of standard deviational ellipses in the application of criminal geographic profiling

The premise for this study is that the physical and cultural landscape has a deterministic effect on the location and distribution of serial crime. As a consequence, the distribution of linked crime scenes should exhibit a shape and orientation that is consistent with the underlying landscape. Geographic Profiling models that are able to account for these effects will provide more accurate results than those models that do not. Utilizing basic geographic principles of central tendency and spatial diffusion, this research first analyzed the output of circular and elliptical profile models generated for 30 serial burglaries (n = 164) and 67 serial robberies (n = 370) in Baltimore, Maryland between 1994 and 1997. A comparative analysis of the model output reveals that the Standard Deviational Ellipse is significantly (p = 0.000) better able to predict the home location of a serial offender than profiles generated from circles. Next, the relationship between the orientation of elliptical profiles and the mean linear orientation of the corresponding landscape was assessed to reveal a moderate but significant correlation (r = 0.511, p < 0.001). Together, these findings demonstrate that landscape does impact the locations of crime, and is a measurable parameter that can improve the efficacy of geographic profiling. Copyright © 2008 John Wiley & Sons, Ltd.     

工作记忆在简单指数乘法等式判断中的作用

选择大学二年级数学系的学生作为被试,要求他们完成控制条件、语音任务、手动任务和随机间隔决策任务条件下的简单指数乘法等式判断任务,实验结果表明：（1）三种次级任务在真假等式判断的反应时上的干扰效应非常显著;（2）三种次级任务显著增加了假等式判断的错误率,但没有显著增加真等式判断的错误率。这说明,语音环路、视空间模板和反应选择成分参与简单指数乘法等式判断,而且真假等式判断具有不同的注意资源需求。     

自我肯定研究述评

自我肯定是指通过肯定与威胁信息无关领域的自我价值,来维持自我整体性,从而降低防御反应。它可以通过完成自我价值观量表、描述重要的个人价值等方式来进行实验操纵。经过自我肯定的个体能更加客观、公正地处理威胁自我认同和群体认同的信息,促进个体的成长。这些作用可能是通过系统地思考说服信息的中央路径的认知加工来实现的。在未来的研究中,对个体最重要价值威胁情况下的自我肯定效应、自我肯定效应的多种机制的共同作用、自我肯定效应与群体肯定效应的区分以及自我与群体肯定效应的跨文化比较等方面还有待进一步的研究。     

中央执行注意资源在消极和积极特征捆绑中的作用

鉴于以往研究未明确视觉工作记忆中特征捆绑是否需要注意资源,以及未考察积极加工条件下的特征捆绑等问题,本研究运用双任务干扰范式,通过两个实验分别在消极加工和积极加工条件下考察了联结客体的特征加工和特征捆绑,以及中央执行注意资源在特征捆绑中的作用。结果表明：联结客体的特征加工不但存在双重存储机制,还存在双重操作机制,这一结果拓展了Wheeler和Treisman（2002）的特征捆绑理论;联结客体的特征捆绑可分为消极特征捆绑和积极特征捆绑两种类型,消极特征捆绑不需要中央执行注意资源的参与,而积极特征捆绑则需要中央执行注意资源的参与。     

Aggressive behavior induced by electrical stimulation in the midbrain central gray of male rats

Electrical stimulation via electrodes implanted in the lateral hypothalamus may induce intraspecific aggressive behavior. Small electrolytic lesions placed via these electrodes resulted in a five– to tenfold increase in the current threshold for aggression. Degenerating fibers were stained by means of the Fink-Heimer method and could be followed caudally to the dorsal midbrain central gray and to the mammillary bodies. A few axons could be traced rostrally to the medial septum. Aggression could be induced from 10 of 112 electrodes implanted in the central gray; the other electrodes elicited either locomotion, vocalization, jump, or “alarm-like reactions.” The morphology of the induced aggression was similar to the morphology of the hypothalamically induced aggression, though it was often accompanied with motor disturbances and was less intense. Hypothalamic stimulation was combined with simultaneous central gray stimulation in rats with electrodes both in the hypothalamus and in the central gray. Hypothalamic thresholds for aggression could be lowered by this stimulation of the central gray, even when no aggressive responses were observed during central gray stimulation alone. This suggests that, although aggression is not manifest, electrical stimulation may activate neural tissue involved in aggressive behavior. It is concluded that in rats central gray and hypothalamus are part of the same neural network mediating intraspecific aggression.     

Effects on memory of early testing and accuracy assessment for central and contextual content

ABSTRACT

Memory for an event is influenced by many factors including retention interval, frequency of assessment, and type of information assessed concerning the event. We examined the usefulness of observer memory for contextual information in assessing accuracy of memory for central information. Participants viewed a video of a purse being stolen and were asked questions concerning the perpetrator and surrounding context of the event, including where and when the event occurred and who else was present. Participants tested immediately after seeing the video exhibited better memory than those tested for the first time 48 hours after the event. Additionally, testing immediately after viewing the video reduced forgetting over the 48-hour delay (i.e. early testing attenuated subsequent forgetting). Moreover, memory for the context of the event correlated positively with memory of the central information (i.e. perpetrator), and memory concerning other people at the event tended to have the highest correlation with perpetrator memory.