融于教学的游戏训练对农村大班幼儿执行功能的促进

本研究采用实验组对照组前测后测设计,对实验组（即干预组）幼儿进行为期3个月的融于教学的多种形式游戏训练（自控力养成、专注力练习、记忆棋游戏）。结果发现：(1)两组幼儿在执行功能的三个维度（工作记忆、抑制控制和认知灵活性）上的前测成绩均无显著差异,但训练后干预组幼儿在认知灵活性上的增量显著高于对照组,工作记忆上的增量略高于对照组;(2)将干预组幼儿依据执行功能水平进行高、低分组划分,发现低执行功能组在三个维度都得到了显著提升,而高执行功能组在工作记忆和抑制控制两个维度上有所提升。研究证明,短期游戏训练一定程度上可以促进农村幼儿执行功能的进步,尤其对执行功能偏低的幼儿效果更佳,显示出补偿发展的特征。     

Assessing inhibitory control in early-stage Alzheimer's and Parkinson's disease using the Hayling Sentence Completion Test

The ability to inhibit irrelevant information is essential for coping with the demands of everyday life. Inhibitory deficits are present in all stages of dementia and commonly observed in people with Parkinson's disease (PwPD). Inhibition is frequently tested with the Stroop test, but this may lack ecological validity. This study investigates inhibitory control in people with Alzheimer's disease dementia (PwD) and PwPD using the Hayling Sentence Completion Test (HSCT), which aspires to be a more ecologically valid task. A total of 117 people completed the HSCT, a test where participants have to complete a sentence with an unrelated word. The sample comprised 30 PwD, 33 PwPD, and 54 healthy older controls. We compared response times and the number and type of errors across the three groups. Completion time in Part B (Inhibition) did not distinguish between PwD, PwPD, and controls when controlling for the initiation speed, but a higher proportion of Category A errors (producing a word that fits the sentence when instructed otherwise) was a unique characteristic of inferior performance in PwD and PwPD. While not part of the standard test scoring protocol, controlling for the initiation speed and distinguishing between speed and accuracy in test performance appear to be essential for accurate evaluation of the inhibitory control in HSCT in older people. The findings suggest that the HSCT may be sensitive to verbal suppression deficits and may provide insight into inhibitory control in PwD and PwPD.     

Accelerated muscle contractility and decreased muscle steadiness following sauna recovery do not induce greater neuromuscular fatigability during sustained submaximal contractions

Acute whole-body hyperthermia (WBH) increases blood markers concentration of stress, impairs motor drive to exercising muscles, and decreases resistance to neuromuscular fatigability. The functional natural residual consequences of WBH on neuromuscular functions remain unclear. We aimed to investigate the effects of residual WBH on voluntary and electrically induced ankle plantar flexor contractility properties, motor drive transmission (reflexes), muscle torque steadiness, resistance to neuromuscular fatigability, and markers of stress as the body temperature recovers naturally to normothermia. WBH was induced by Finnish sauna bathing in 16 apparently healthy young (24 ± 4 years) adult men. Motor performance was monitored before and 2 h after the sauna, and immediately after submaximal exercise (120 s at 50% of maximal voluntary contraction). Markers of stress were monitored before and 2 h after the sauna. Finnish sauna exposure induced moderate to severe WBH (rectal temperature, 38.5–39.6 °C). At 2 h after the sauna, rectal temperature had recovered to the preheating level (preheating 37.11 ± 0.33 °C versus postheating 37.00 ± 0.29 °C, p > .05). Post-sauna recovery was accompanied by slowed salivary free cortisol diurnal kinetics, whereas noradrenaline, dopamine, and serotonin did not persist into the 2 h recovery after the sauna. Although recovery to normothermia after a sauna led to a greater acceleration of muscle contractility properties and decreased muscle steadiness, sustained isometric submaximal contraction did not provoke greater neuromuscular fatigability.     

意外地点任务中不同测试问题及意图理解与执行功能的关系

旨在讨论意外地点任务中“知否问题”与“预测问题”可能存在的差异及两者与执行功能任务的关系,并初步探讨意图理解与执行功能间的关系。用意外地点任务、膝跳反射任务和两个执行功能的任务（DCCS和手部游戏）对59名3~5岁的儿童施测。结果显示：（1）儿童在意外地点任务的“知否问题”上的表现显著好于“预测问题”,儿童对“知否问题”和“预测问题”的回答可能反映了心理理论发展的不同阶段。（2）膝跳反射任务,DCCS任务与“知否问题”三者间有显著的相关,且其高相关在排除年龄及语言能力的影响后仍保持显著。“双表征区分结构”可能是三者间具有共同的成分。     

存在问题的逻辑语言维度

存在问题在分析哲学的背景下取得了深入细致的研究成果。在“何谓存在”问题上,围绕“存在”是不是个体的属性从而是不是逻辑谓词的争论呈现出三派观点:弗雷格、罗素等从一阶逻辑出发,认为“存在”不是逻辑谓词,而是量词;皮尔士、斯特劳森等结合精致的自然语言分析,认为“存在”在某些特殊情况下表达了个体的属性,是一种特殊的谓词;自由逻辑学家则从自由逻辑的角度给出了肯定的答案。在“何物存在”问题上,蒯因“存在就是约束变项的值”的本体论承诺标准机智地揭示了存在问题的语言学实质。可以说,利用一阶逻辑解释存在问题的方法是比较成功的。如果将弗雷格、罗素的一阶语言扩展到高阶语言,则既能与蒯因的理论连贯一致,又能避免无谓的“存在”本体论纷争。这种做法的结果是“存在”具有了层次性的特征。掌握一定的逻辑学基础知识,有助于我们深入研究西方哲学。     

干细胞移植技术离临床治疗应用到底还有多远

骨髓细胞移植是一种早期的干细胞移植性治疗方式.干细胞分离纯化技术的革命,尤其是干细胞移植在各种临床疾病治疗中近期疗效的不断报道促成了干细胞移植技术的推广迅猛发展.胚胎干细胞或成体干细胞如何分化形成指定的有恰当功能的组织器官一直是发育生物学家和干细胞移植科学家们关注的重大研究课题.实际上,干细胞移植治疗既存在理论性困惑,又存在技术性问题,因此干细胞移植技术的实际应用前途是光明的,但道路是曲折的.     

论我国艾滋病防治工作中的政府职能

艾滋病是世界性的重大公共卫生问题和社会问题。近年来,我国艾滋病的流行呈现快速上升趋势,流行范围广,局部地区疫情相当严重,疫情正在从高危人群向一般人群传播。政府的组织领导是做好我国艾滋病防治工作的根本保证,各级政府要强化政府的公共卫生职责,发挥政府的主导作用,动员足够的防治资源和力量,引导社会各方面力量的广泛参与,打一场防治艾滋病的“人民战争”,我们一定能够控制艾滋病的流行。     

Empirical evaluation of a model of global psychophysical judgments: III. A form for the psychophysical function and intensity filtering

In part I, a concept of ratio estimation is defined and it is shown that if such estimates depend only upon the physical ratio of the signal to the reference signal, the psychophysical function must be a power function. Assuming the same exponents for each component, an invariance condition, equivalent to a sum of power functions, is studied empirically for binaural loudness. It is fully or partially sustained for 19 of 22 respondents. Since failures may be attributable to different exponents in the two ears, the ratio of the two exponents is estimated but that fails to explain the failures. Other possible explanations are suggested. In part II, an intensity filtering model is presented, accounting for the phenomenon where monaural loudness matches show a bias depending on the matching ear. We show (a) that the existence of such a bias does not alter the prior experimental results; and (b) assuming the power function, that five respondents attenuate the opposite ear and two enhance it.     

Function, Intuition and Ends in Aristotle's Ethics

This essay attempts to show why deliberation is not of ends for Aristotle, not only because deliberation is concerned with means, but because ends are grasped by wish. Such wishing, I argue, is a form of rational intuition that is non-discursive and analogous to seeing and therefore not at all like the discursive thought involved in deliberation. Such a reading also helps shed light on the nature of contemplation and therefore on happiness in Aristotle.