5, 7-dihydroxytryptamine lesions: Effects on body weight,irritability, and muricide

Forty-four male rats were subjected to injections of 5,7dhydroxytryptamine (40 μg/4 μ1) in the ascending 5-hydroxytryptamine projection or control operations. The injections resulted in depletion of forebrain 5-hydroxytryptamine, weight loss, irritability, and muricide. No significant correlations were found between any of these effects. It is suggested that the neural systems mediating regulation of body weight and muricide are substantially distinct.     

Body weight and response acquisition with delayed reinforcement.

The relation between body weight and responding established with unsignaled delayed reinforcement was investigated. In three experiments, naive rats were deprived to either 70%, 80%, or 90% of ad libitum weight and were then exposed to tandem variable-interval 15-s differential-reinforcement-of-other-behavior 30-s schedules. The tandem schedule defined a resetting unsignaled delay-of-reinforcement procedure. In the first experiment, speed of magazine training, acquisition of lever pressing, and final rate of lever pressing were related to body weight. In the next experiment, lever pressing was established and maintained in rats that were magazine trained at 70% of ad libitum weight but that were then exposed to the delay procedure at 90% of ad libitum weight. Responding did not change consistently either across or within subjects in subsequent conditions in which body weight was manipulated. In the final experiment, lever pressing was established and maintained with delayed reinforcement in the absence of magazine training for each of 2 rats at 70% and for 1 of 2 rats at 90% of ad libitum weight. The results further illuminate the conditions under which responding can be established in the absence of training and when such responses are reinforced only following an unsignaled delay period.     

关于早期知觉过程中注意资源分配权重的实验研究

本研究将早期知觉过程中分配的资源比例理解为权重。实验采用中心提示法,探讨了字母、数字、图形和颜色四种刺激特征的早期识别过程中资源分配权重问题。结果发现：（１）颜色不易受到提示的影响,而其它三个特征则受提示的影响较大;（２）在弱提示位置上,对数字的识别比对字母和图形的识别要难,而在强提示位置上,则相差不大。说明这四种刺激特征的注意权重在知觉加工的初始阶段是不同的;这种“不同”是早期知觉过程中刺激因素与注意资源分配之间相互作用的结果。     

Analysis of contingency tables by ideal point discriminant analysis

Cross-classified data are frequently encountered in behavioral and social science research. The loglinear model and dual scaling (correspondence analysis) are two representative methods of analyzing such data. An alternative method, based on ideal point discriminant analysis (DA), is proposed for analysis of contingency tables, which in a certain sense encompasses the two existing methods. A variety of interesting structures can be imposed on rows and columns of the tables through manipulations of predictor variables and/or as direct constraints on model parameters. This, along with maximum likelihood estimation of the model parameters, allows interesting model comparisons. This is illustrated by the analysis of several data sets.Presented as the Presidential Address to the Psychometric Society's Annual and European Meetings, June, 1987. Preparation of this paper was supported by grant A6394 from the Natural Sciences and Engineering Research Council of Canada. Thanks are due to Chikio Hayashi of University of the Air in Japan for providing the ISM data, and to Jim Ramsay and Ivo Molenaar for their helpful comments on an earlier draft of this paper.     

Evidence of improved fluid management in patients receiving haemodialysis following a self-affirmation theory-based intervention: A randomised controlled trial

Objective: Haemodialysis patients are at risk of serious health complications; yet, treatment non-adherence remains high. Warnings about health risks associated with non-adherence may trigger defensive reactions. We studied whether an intervention based on self-affirmation theory reduced resistance to health-risk information and improved fluid treatment adherence.

Design: In a cluster randomised controlled trial, 91 patients either self-affirmed or completed a matched control task before reading about the health-risks associated with inadequate fluid control.

Outcome measures: Patients’ perceptions of the health-risk information, intention and self-efficacy to control fluid were assessed immediately after presentation of health-risk information. Interdialytic weight gain (IDWG), excess fluid removed during haemodialysis, is a clinical measure of fluid treatment adherence. IDWG data were collected up to 12 months post-intervention.

Results: Self-affirmed patients had significantly reduced IDWG levels over 12 months. However, contrary to predictions derived from self-affirmation theory, self-affirmed participants and controls did not differ in their evaluation of the health-risk information, intention to control fluid or self-efficacy.

Conclusion: A low-cost, high-reach health intervention based on self-affirmation theory was shown to reduce IDWG over a 12-month period, but the mechanism by which this apparent behaviour change occurred is uncertain. Further work is still required to identify mediators of the observed effects.     

肝素、低分子肝素诱导的重症血小板减少2例救治分析

探讨肝素/低分子肝素诱导的重症血小板减少救治经验与规律.对2例分别使用肝素、低分子肝素后出现重症血小板减少患者发病、临床特征、实验室检查等进行分析,进一步提高该类重症病的认识,总结救治经验：严密监测,早期发现,一旦出现重症血小板减少,及时停用肝素和/或低分子肝素,换用非肝素类抗凝药;立即激素（地塞米松30mg/d）冲击治疗2天,重症血小板减少（PLT≤3×109/L）并出血者酌情输注血小板.     

A prospective study of pressures from parents, peers, and the media on extreme weight change behaviors among adolescent boys and girls

The current study was designed to evaluate the role of sociocultural influences over a 16 month period on strategies to lose weight, extreme weight loss strategies, and strategies to increase muscles among adolescent boys (n=344) and girls (n=246). All participants completed measures of body dissatisfaction, body image importance, strategies to lose weight, extreme weight loss strategies, and strategies to increase muscles. Measures of perceived pressure to lose weight or increase muscles from mother, father, best male friend, best female friend and the media were also evaluated. Data were gathered on three occasions, 8 months apart. The results demonstrated that boys showed a decrease in strategies to lose weight and increase muscles over time, whereas girls showed an increase. Both boys and girls showed an increase in extreme weight loss strategies with girls demonstrating a greater increase than boys. The sociocultural influences generally were perceived by girls to relate to messages to lose weight, whereas for boys they were perceived to relate to increasing muscles. Messages from parents, particularly fathers, were strong predictors of both strategies to lose weight and increase muscles among boys, with the media and best male friend playing a limited role. For girls, the strongest influences were mothers and best female friends, with few influences from fathers or the media. The results of this study are discussed in terms of the importance of the various sociocultural influences in shaping body change strategies among young adolescent boys and girls, and the implications of these findings for intervention programs for adolescents.     

Bring It On: Proactive Coping with Discrimination

We investigated proactive coping with discrimination among heavy women in both a high impact lab study (101 women) and a daily diary study (62 women). Heavy women assessed greater harm and fewer coping resources for discriminatory, as compared to non-discriminatory, hassles (Study 2). Primary appraisals of harm were important determinants of proactive coping, including primary control (attempts to change the environment) and secondary control (attempts to change the self to fit the environment) directed at discriminatory stressors (Studies 1 and 2). When heavy women used primary control coping efforts, they experienced positive interpersonal outcomes (Study 1) and less negative intrapersonal outcomes (Study 2). We discuss the benefits and limitations of engaging in proactive coping and suggest avenues for future research.

Treating Bulimia Nervosa and Achieving Medically Required Weight Loss: A Case Study

Eating disorder and weight loss interventions have typically been regarded as distinct or antithetical, despite a growing number of individuals with comorbid eating pathology and obesity. This siloing of research and practice has created a clinical conundrum for providers seeking to treat individuals with an eating disorder seeking to lose weight (e.g., required pre-surgical weight loss). To date, integrated treatment research targeting both eating disorders and weight loss is rare and practical guidance is lacking, especially for restrictive/binge-purge subtypes. This case example describes how an integrated approach was applied within a naturalistic outpatient clinical practice setting to successfully treat a client presenting with excess weight and severe bulimia nervosa who was medically required to lose weight for orthopedic surgery. We conclude by reviewing the benefits and challenges of integrating eating disorder and behavioral weight loss treatments and providing practical insights for treatment providers.     

Weight Bias Internalization and Psychosocial,Physical, and Behavioral Health: A Meta-Analysis of Cross-Sectional and Prospective Associations

Coinciding with widespread efforts to address obesity, weight bias internalization (a process of self-devaluation wherein individuals apply weight-biased stereotypes to themselves) has gained increased attention as a robust correlate of poor health outcomes. The present meta-analysis aimed to provide the largest quantitative synthesis of associations between weight bias internalization and health-related correlates. Studies that provided zero-order correlations for cross-sectional or prospective associations between weight bias internalization and physical, psychosocial, and behavioral health correlates were included in the meta-analysis. Meta-regression determined whether these associations differed based on demographic (sex/gender, race, age), anthropometric (body mass index), and study-level (publication status, sample type, study quality) moderators. Data for 149 (sub)samples were identified that included between 14 and 18,766 participants (M sample size = 534.96, SD = 1,914.43; M age = 34.73, SD = 12.61, range = 9.95–65.70). Results indicated that greater weight bias internalization was concurrently associated with worse psychosocial (e.g., negative and positive mental health, social functioning), physical (e.g., BMI, weight maintenance, health-related quality of life [HRQoL]), and behavioral health (e.g., disordered eating behaviors, healthy eating, physical activity) across most constructs, with effects ranging from small to very large in magnitude. Preliminary evidence also suggested that greater weight bias internalization was subsequently associated with less weight loss and increased negative mental health. Notable variations in the nature and magnitude of these associations were identified based on the health-related correlate and moderator under consideration. These findings indicate that weight bias internalization is linked to multiple adverse health-related outcomes and provide insight into priorities for future research, theory building, and interventions in this area.