Pirh2在分化型甲状腺癌中的表达及意义

探讨Pirh2、P53在分化型甲状腺癌(DTC)中的表达及其意义.随机选取湖南省人民医院乳腺甲状腺外科2006.6～2011.6间DTC64例,应用免疫组化法检测癌组织中的Pirh2、P53的表达.并以结节性甲状腺肿等良性甲状腺疾病病例作为对照,分析Pirh2、P53对DTC的可能作用.Pirh2、P53分别在64例DTC中阳性表达为68.8％ (44/64)、28.1％(18/64),而在36例甲状腺良性疾病中阳性表达为25％(9/36)、16.7％(6/36).Pirh2在DTC与良性肿瘤间的表达存在差异显著性(P＜0.001).P53在两者间的表达无差异显著性(P＞0.05).Pirh2表达与P53的表达具有正相关性(r=0.316、P＜0.05).Pirh2在DTC中呈较高表达,而在良性甲状腺疾病中表达率低,Pirh2可能与P53共同调节DTC的发生发展.     

大剂量抗坏血酸静脉滴注治疗恶性肿瘤的进展

尽管30年前鲍林与卡梅伦曾经用静脉注射+口服大剂量维生素C(10克/天)治疗肿瘤患者,并验证抗坏血酸的抗癌功效,但梅约医疗中心的口服双盲试验否定了他们的结论.沉寂30年后,鲍林的继承者瑞欧丹通过不懈的努力用科学实验和医疗实践证明,通过静脉滴注大剂量抗坏血酸,令其在血浆达到一定浓度,可以杀死多种癌细胞,从而作为化疗药物可以有效治疗恶性肿瘤.30年来的临床实践现已总结为“瑞欧丹规程”.近年来,他们的成就受到美国主流医学和媒体的高度重视.与一般化疗药物相比,该法的好处是基本没有副作用,延长生存期,提高存活质量(QOF).这是一项重大科学发现和成就.该疗法的确立意义重大,将推动癌的治疗及预防,乃至其他疾病如冠心病、感染性疾病及炎症的治疗及预防,提高人类健康水平.     

The Rise and Decline of the American Asylum Movement in the 19th Century

This paper traces the history of the American public asylum from the 1840s through the late 19th century. The focus is on social factors that contributed to the establishment of public institutions at the urging of reformers, the attempts to model them on the architecture and “moral treatment” offered by the best private institutions, the crowding of the asylums, the growing criticism aimed at the asylums and their superintendents, and the effects of calls for other approaches and for scientific management. Knowledge of the asylum's history may be useful today, as we stand at the crossroads in the treatment of the mentally ill.     

The Efficiency of the Group Rorschach Test in the Psychiatric Screening of Marine Corps Recruits

In a study to extend the theory of cognitive dissonance into the area of person perception, 108 male freshmen dormitory students were led to believe that they either would or would not be sharing a room in the future with a negative other. They were also informed that they were either low, moderate, or high in similarity to this negative other. The major response measure was the extent to which the negative first impression changed in a more positive direction. A 2 × 3 ANOVA showed that both the proximity and similarity manipulations had the predicted effect. However, the trend in similarity was not linear, as hypothesized. Similarity was also found to be a more salient source of dissonance than proximity.     

Community Living Skills

Persons with chronic mental health problems are frequently found living in the community at varying quality of life levels. Though rehabilitation programs are suitable for patients with acute exacerbations of mental health pathology, these programs are necessary but not sufficient to meet the needs of the chronic person. Long-term reliance on biomedically-based rehabilitation can produce dependence on the system and maintain reliance on the "sick role" which is counterproductive for current trends related to deinstitutionalization and "least restrictive environment." The intent of this article is to focus on an one alternative service delivery model- psychoeducation. The potentials for this mode to normalize or maximize independence is discussed and two community living skills programs for the chronically mentally ill are described to exemplify the application of psychoeducation.     

The effect of chronic caffeine consumption on urinary incontinence in psychogeriatric inpatients

Abstract

Urinary incontinence is a common problem in psychiatric settings, particularly among psychogeriatric patients. In view of the known diuretic action of caffeine, the present study assessed the effect of tea and coffee consumption on level of incontinence in selected psychogeriatric inpatients. A total of 14 patients participated in the study which employed a combined “withdrawal” and “multiple-baseline across subjects” design to examine the effect of alternating phases of caffeine exposure and abstinence on frequency of daytime and nighttime incontinence. Incontinence levels were significantly reduced during periods of caffeine abstinence relative to periods of chronic caffeine exposure. The hypothesis that observed reductions in incontinence may have been due to accompanying reductions in fluid intake was examined but not supported.     

Health psychology and uptake of preventive health services: A review of 30 years' research on cervical screening

Abstract

A review of thirty years' research in cervical screening was conducted to assess the role of social and psychological factors in screening utilisation. The role of age, social class, attitudes towards and beliefs about screening as well as social influence and personality variables are considered. A reanalysis of reasons for non-attendance following an invitation for screening from ten previous studies is presented and the importance of theoretical accounts of service utilisation in this area are assessed. Research findings show significant associations for both demographic and psychological factors though poor operationalisations and statistical analyses in previous research make difficult the assessment of their importance as additive, interactive or mediational variables. The significance of service provision issues in terms of both providers' behaviour and the flexibility of delivery is highlighted. The need for further research using a theoretical framework which can unify demographic, psychological and service provision variables is identified.     

A survey of smoking status and cancer risk perceptions among participants attending a hospital-based head and neck screening program

Abstract

Screening for head and neck cancer is underutilized. Given that lack of knowledge of the risk factors may partially account for screening underutilization. we surveyed subjective risk and knowledge of risk factors for head and neck cancer among 124 individuals who attended a free. hospital-based head and neck cancer screening. Few participants were current smokers. Most attendees perceived their risk as similar to others of their age and sex. Personal health habits comprised almost all of the risk-decreasing factors, yet less than half of the risk-increasing factors. generated. Personal habits were less frequently endorsed than factors such as pollution and heredity. Those who mentioned a risk behavior, or a family cancer history, reported higher subjective risk. Those who mentioned a personal health habit reported lower subjective risk. Results highlight needed efforts to increase screening among high-risk individuals through targeted education messages.     

Risk factors for psychological morbidity in women attending a one-stop diagnostic clinic with suspected breast disease

Abstract

The present study was designed to identify risk factors for psychological morbidity in women attending a one-stop diagnostic clinic with suspected breast disease. A cohort of 158 women were recruited and were asked to complete scales measuring psychological morbidity and psychosocial factors in the period immediately before their appointment and to repeat the assessments of psychological morbidity on the day of the appointment. Relevant clinical and demographic data were also collated. Within the cohort 1.4% of respondents received a diagnosis of malignant disease. Psychological morbidity, both prior to and during the diagnostic appointment was strongly predicted by psychosocial factors (i.e., acceptance-resignation coping, personal self esteem and discrepancies in social support), accounting for 54% and 63% of the variance at pre-appointment and appointment day phases respectively. Other measured variables were found not to be correlated with and/or to account for a significant proportion of the variance in the measures of morbidity. These results suggest that these psychosocial variables should be targeted in interventions designed to reduce psychological morbidity in this patient group.     

A Burden to Others: A Common Source of Distress for the Terminally Ill

Recent research into the desire for death among people with terminal illness has begun to recognize the importance of “feeling oneself a burden to others” as a factor in suicidal behaviour. In this study, 69 patients with advanced cancer underwent semi‐structured interviews. The sense of self‐perceived burden was found to be a common experience, reported by 39.1% of participants as a minimal or mild concern and by 38% as a moderate to extreme concern. The sense of burden showed a low correlation with physical symptoms (r = 0.02–0.24) and higher correlations with psychological problems (r = 0.35–0.39) and existential issues (r = 0.45–0.49). Comparisons of participants with high or low levels of self‐perceived burden showed the importance of this factor for overall quality of life. In summary, self‐perceived burden is an important but underestimated dimension of social cognition in the medically ill.