错误相关负波（ERN）在精神病理学研究中的应用

错误相关负波（error-related negativity, ERN）是由行为错误诱发的一种脑电波成分,最大峰值在错误反应之后的50ms左右,偶极子源定位于前扣带回（anterior cingulate cortex, ACC）附近。错误加工（error processing）的经典研究范式中出现的ERN成分可能反映了ACC具有错误检测、冲突监控、强化学习、情绪动机等功能。大量研究表明过度的和不足的错误相关脑活动（hyperactive and hypoactive error processing）可能分别与精神病理学的内化性和外化性障碍（internalizing and externalizing disorders）相关联。内化性和外化性障碍的内表型（endophenotype）的研究,还存在许多值得进一步探索的问题。     

脑功能可塑性与灾后心理功能康复

神经系统具有惊人的可塑性,这种可塑性可以终生保留。大脑不仅可因个体的经验与行为而改变,也可因内在思维、放松和注意的不同而发生改变。如汶川地震这样的大型自然灾害,因其突发性和巨变性,可使身临其境的人大脑功能状态在瞬间就发生持久的改变,从而表现为认知、情感等心理功能的改变。反过来,利用有关神经可塑性的认识,同样可使受损的大脑得以修复,使发育障碍的个体增强功能,亦可使由各种内外因素导致的心灵扭曲重新舒展开来。利用放松、修复、重建的3R脑功能重塑技术,可望解决包括地震灾后心理健康重建在内的各种神经和心理问题,具有广泛的应用前景     

MINDS, INTRINSIC PROPERTIES, AND MADHYAMAKA BUDDHISM

Certain philosophers and scientists have noticed that there are data that do not seem to fit with the traditional view known as the Mind/Brain Identity theory (MBI). This has inspired a new theory about the mind known as the Hypothesis of Extended Cognition (HEC). Now there is a growing controversy over whether these data actually require extending the mind out beyond the brain. Such arguments, despite their empirical diversity, have an underlying form. They all are disputes over where to draw the line between intrinsic and relational causal powers. The second-century Buddhist philosopher Nagarjuna deals with similar issues when he argues for a middle way between the two positions that were known in his time by the terms eternalism and nihilism. Eternalism, like MBI, asserts that the mind is a permanent enduring substance (although the two theories disagree as to how long mind endures). Nihilism argued that the mind had no intrinsic existence, and today some argue that HEC could lead us to a similar conclusion. Nagarjuna's argument for a middle way between these two extremes is similar to an argument that can be made for HEC. We can accept that neither the brain nor any other single physical item is identical to the mind without falling down the slippery slope that leads to "The mind does not really exist, and therefore we are one with everything." Nagarjuna was correct to say that the mind has conventional reality—that the mind exists even though there is no sharp border between the mind and the world.     

USING DIFFERENTIAL REINFORCEMENT TO DECREASE ACADEMIC RESPONSE LATENCIES OF AN ADOLESCENT WITH ACQUIRED BRAIN INJURY

The present study investigated the effects of contingency‐specifying rules and a token economy to decrease the latency to comply with academic instructions by a 16‐year‐old girl with acquired brain injury. Results showed that treatment was successful in reducing academic response latencies. These results replicate previous research in which differential reinforcement was used to decrease slow responding to academic tasks.     

Lateralization of egocentric and allocentric spatial processing after parietal brain lesions

The purpose of this paper was to verify whether left and right parietal brain lesions may selectively impair egocentric and allocentric processing of spatial information in near/far spaces. Two Right-Brain-Damaged (RBD), 2 Left-Brain-Damaged (LBD) patients (not affected by neglect or language disturbances) and eight normal controls were submitted to the Ego-Allo Task requiring distance judgments computed according to egocentric or allocentric frames of reference in near/far spaces. Subjects also completed a general neuropsychological assessment and the following visuospatial tasks: reproduction of the Rey-Osterreith figure, line length judgement, point position identification, mental rotation, mental construction, line length memory, line length inference, Corsi block-tapping task. LBD patients presented difficulties in both egocentric and allocentric processing, whereas RBD patients dropped in egocentric but not in allocentric judgements, and in near but not far space. Further, RBD patients dropped in perceptually comparing linear distances, whereas LBD patients failed in memory for distances. The overall pattern of results suggests that the right hemisphere is specialized in processing metric information according to egocentric frames of reference. The data are interpreted according to a theoretical model that highlights the close link between egocentric processing and perceptual control of action.     

Anomalous brain dominance and the immune system: Do left-handers have specific immunological patterns?

Geschwind and Behan (1982) and Geschwind and Galaburda (1985a, 1985b, 1985c) suggested a correlation between brain laterality and immune disorders. To test whether this hypothesis holds true not only for the frequency of immune diseases and circulating autoantibodies, but extends also to cellular immunity, we examined the association between handedness and markers of cellular immunity. Twenty-seven left-handed and 37 right-handed subjects were serologically screened for cellular parameters and 22 left-handed subjects were typed for human leukocyte antigen (HLA). When compared to the right-handers, the left-handed group showed a significant decrease in the inflammatory cell types CD3(+) T cells (total T cells), CD4(+) T cells (T-helper cells), and HLA-Dr (MHC-II, antigen-presenting cells) as well as in the CD19(+) cells (B cells) and CD16/CD57(+) cells (natural killer cells). We assume a relationship exists between cerebral hemispheric specialisation and the immune system not only for humoral but also for cellular immunity, and we discuss the role of the major histocompatibility complex in neurological and immunological development.     

共情的认知神经研究回顾

共情是指个体对他人情绪和想法的感受及理解,它在人类个体和社会的发展中起到了重要作用。近年来,脑成像技术为研究共情的神经基础提供了有力的技术支持,发现了共情的关键功能脑区。基础与临床的实验证据表明,更好地理解共情的神经机制对于孤独症、反社会人格等精神障碍有重要的意义。该文对相关的研究进行了综述并对未来可能的研究方向提出了展望     

自我和他人的协调与心理理论的神经机制

有关心理理论神经机制的研究远未达到共识。从自我与他人协调的角度看,可认为它是一个由多脑区有机组织而成的系统。自我中心化偏差是人类认知的一种默认选择,要正确理解他人的心理状态,需要抑制自我中心偏差。因此,心理理论的加工至少包括以下几个不同的过程：通过模拟自我理解他人,相应的加工脑区为镜像神经元系统;从他人与客体形成的二元关系中表征心理状态的内容,相应脑区是颞顶联合区;对模拟自我进行抑制,相应脑区为背外侧额叶;以及整合协调以上几个过程,其脑区可能是内侧前额叶     

发展中的行为决策研究

行为决策研究人们如何进行判断与选择。该学科希望能在描述决策的过程中帮助人们更好地进行决策,其研究的使命是促进和改善我们对人类决策行为的理解。在过去的1年里,中国科学院心理研究所行为决策课题组在社会与经济决策领域中已开展的研究包括：行为决策与脑、社会互动与决策、决策的文化差异、消费与投资的行为决策、效用最大化与幸福感。该文着重报告并讨论了我们在行为决策及其跨文化比较研究中的一些最新的主要发现     

关于条件推理的ERP研究

以抽象的条件命题作为实验材料,测定13名大学生在完成MP、AC、DA、MT推理（推测判断任务）和基线任务（记忆判断任务）时的事件相关电位（ERP）,初步探讨不同推理类型的脑内时程动态变化。这是使用ERP技术来研究条件推理脑机制的初步尝试。结果发现,五种任务所诱发的ERP早成分均不存在显著差异,在头皮前部的左外侧额区和左颞区,MP与DA推理与基线任务相比,均诱发一个更明显的晚期正成分（450-1100ms）,在右外侧额区则诱发一个更明显的晚期负成分（450~1100ms）;与之相反,MT与AC推理与基线任务相比,在左侧诱发一个更明显的晚期负成分（450~1100ms）,在右侧诱发一个更明显的晚期正成分（450~1100ms）,这一结果可能是由于左右脑在推理中的认知功能以及四种推理类型之间存在的差异所致,同时也表明推测过程主要激活了左右侧的前额部、颞叶等区域,基本支持Goel等人的双加工理论