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721.
We investigated the trauma narratives of 131 road traffic accident survivors prospectively, at 1 week, 6 weeks, and 3 months post-trauma. At 1 and 6 weeks, narratives of survivors with acute stress disorder (ASD) or post-traumatic stress disorder (PTSD) were less coherent and included more dissociation content. By 3 months, their narratives also contained more repetition, more non-consecutive chunks, and more sensory words. Traumatic brain injury was associated with a separate characteristic, confusion, at all three time points. Three aspects of narrative organisation at 1 week--repetition, non-consecutive chunks, and coherence--predicted PTSD severity at 3 months after controlling for initial symptoms. The results suggest both a strong concurrent and predictive relationship between narrative disorganisation and ASD/PTSD but that as people recover from ASD, their narratives do not necessarily become less disorganised. 相似文献
722.
Swanson JM Kinsbourne M Nigg J Lanphear B Stefanatos GA Volkow N Taylor E Casey BJ Castellanos FX Wadhwa PD 《Neuropsychology review》2007,17(1):39-59
Multiple theories of Attention-Deficit/Hyper- activity Disorder (ADHD) have been proposed, but one that has stood the test
of time is the dopamine deficit theory. We review the narrow literature from recent brain imaging and molecular genetic studies
that has improved our understanding of the role of dopamine in manifestation of symptoms of ADHD, performance deficits on
neuropsychological tasks, and response to stimulant medication that constitutes the most common treatment of this disorder.
First, we consider evidence of the presence of dopamine deficits based on the recent literature that (1) confirms abnormalities in dopamine-modulated frontal-striatal circuits, reflected
by size (smaller-than-average components) and function (hypoactivation); (2) clarifies the agonist effects of stimulant medication
on dopaminergic mechanisms at the synaptic and circuit level of analysis; and (3) challenges the most-widely accepted ADHD-related
neural abnormality in the dopamine system (higher-than-normal dopamine transporter [DAT] density). Second, we discuss possible
genetic etiologies of dopamine deficits based on recent molecular genetic literature, including (1) multiple replications that confirm the association of ADHD with
candidate genes related to the dopamine receptor D4 (DRD4) and the DAT; (2) replication of differences in performance of neuropsychological
tasks as a function of the DRD4 genotype; and (3) multiple genome-wide linkage scans that demonstrate the limitations of this
method when applied to complex disorders but implicate additional genes that may contribute to the genetic basis of ADHD.
Third, we review possible environmental etiologies of dopamine deficits based on recent studies of (1) toxic substances that may affect the dopamine system in early development and contribute substantially
to the etiology of ADHD; (2) fetal adaptations in dopamine systems in response to stress that may alter early development
with lasting effects, as proposed by the developmental origins of health and disease hypothesis; and (3) gene-environment
interactions that may moderate selective damage or adaptation of dopamine neurons. Based on these reviews, we identify critical
issues about etiologic subtypes of ADHD that may involve dopamine, discuss methods that could be used to address these issues,
and review old and new theories that may direct research in this area in the future. 相似文献
723.
Experience-dependent changes of spine structure and number may contribute to long-term memory storage. Although several studies demonstrated structural spine plasticity following associative learning, there is limited evidence associating motor learning with alteration of spine morphology. Here, we investigated this issue in the cerebellar Purkinje cells using high voltage electron microscopy (HVEM). Adult rats were trained in an obstacle course, demanding significant motor coordination to complete. Control animals either traversed an obstacle-free runway or remained sedentary. Quantitative analysis of spine morphology showed that the density and length of dendritic spines along the distal dendrites of Purkinje cells were significantly increased in the rats that learned complex motor skills compared to active or inactive controls. Classification of spines into shape categories indicated that the increased spine density and length after motor learning was mainly attributable to an increase in thin spines. These findings suggest that motor learning induces structural spine plasticity in the cerebellar Purkinje neurons, which may play a crucial role in acquiring complex motor skills. 相似文献
724.
神经经济学:迈向脑科学的决策科学 总被引:2,自引:0,他引:2
神经经济学是一门应用神经科学技术来确定经济决策的神经机制的新兴学科。文章首先概述了神经经济学这一学科,说明了经济学、心理学和神经科学与神经经济学之间的关系并主要介绍决策与奖惩系统和情绪在神经经济学中的研究发现及相关理论。文章最后评价了神经经济学在发展中的问题。 相似文献
725.
Randall R. Benson D. H. Whalen Matthew Richardson Brook Swainson Vincent P. Clark Song Lai Alvin M. Liberman 《Brain and language》2001,78(3):364-396
Candidate brain regions constituting a neural network for preattentive phonetic perception were identified with fMRI and multivariate multiple regression of imaging data. Stimuli contrasted along speech/nonspeech, acoustic, or phonetic complexity (three levels each) and natural/synthetic dimensions. Seven distributed brain regions' activity correlated with speech and speech complexity dimensions, including five left-sided foci [posterior superior temporal gyrus (STG), angular gyrus, ventral occipitotemporal cortex, inferior/posterior supramarginal gyrus, and middle frontal gyrus (MFG)] and two right-sided foci (posterior STG and anterior insula). Only the left MFG discriminated natural and synthetic speech. The data also supported a parallel rather than serial model of auditory speech and nonspeech perception. 相似文献
726.
There often appears to be a striking correspondence between mythic stories and aspects of reality. We will examine the processes of creative imagination within a neurobiological frame and suggest a theory that may explain the functions of myth in relation to the hidden aspects of reality. Myth is peppered with archetypal entities and interactions that operate to reveal hidden processes in reality that are relative to the human condition. The imagery in myths in a sense "sustains the true." That is, mythopoetic imagery keeps the interpretive process in experience closer to the actual nature of reality than the rational faculties operating alone are able to do. Indeed, whereas rationalizing can easily lead us awry, genuine myth rarely does. Explanations of events offered by cultures around the world are frequently couched in terms of mythic themes and events. An important function of myth is to provide a "field of tropes" that in-forms the lived experience of people. This paper focuses especially on those aspects of myth that represent facets of the quantum universe and give us clues as to the relationship between consciousness, symbolism, and reality. 相似文献
727.
Laura H. Schopp Cheryl L. Shigaki Brick Johnstone Heather A. Kirkpatrick 《Journal of clinical psychology in medical settings》2001,8(3):181-188
This study examined gender differences in cognitive and emotional status after traumatic brain injury (TBI) among 262 men and 140 women with TBI referred for neuropsychological evaluations. In this cross-sectional study, cognition was measured in terms of both absolute level of functioning (i.e., raw/standard scores) and estimated decline from premorbid levels expressed as z-deficit scores in the following domains: intelligence [Wechsler Adult Intelligence Scale—Revised (WAIS-R)], memory and attention [Wechsler Memory Scale—Revised (WMS-R)], processing speed (Trails A), and cognitive flexibility (Trails B). Emotional functioning was measured in terms of depression (Beck Depression Inventory) and general emotional distress (Brief Symptom Inventory). Kruskal–Wallis nonparametric one-way ANOVAs indicated that women and men differed significantly on 2 of 8 raw/standard cognitive scores [men demonstrated lower WMS-R General Memory (p < .05) and Trails B scores (p < .0001) and 4 of 8 relative decline scores [women demonstrated more estimated change in VIQ (Verbal IQ) [p < .0001], FSIQ (Full Scale IQ) [p < .01], and Attention (p < .01)]; men demonstrated greater estimated z-decline scores on Trails B (p < .01)]. Women reported significantly higher levels of depression (p < .01), but men endorsed significantly greater general psychological distress (p < .05). Research and assessment recommendations are suggested. 相似文献
728.
人类的判断并非十分精确,而且人类还无法清醒认识到自己判断并不准。进化心理学理论认为看似不精确的判断最小化了人类付出的生存代价,从而使个体具有更大的收益,在竞争资源中具有适应优势;而脑科学领域运用fMRI、TMS等技术发现了前额叶的某些区域与判断的精确性有关。未来的研究有待结合进化发展心理学的角度、进化适应的现实解释性角度和认知神经科学发现临床应用的角度展开。 相似文献
729.
默认网络是静息状态活动较强的大脑结构, 它包含的海马和内侧前额叶两个脑区是记忆巩固的关键部位, 同时静息态也被证明伴随有记忆巩固现象, 我们推测默认网络是睡眠依赖记忆巩固的核心结构。本研究拟借助同步EEG-fMRI在时空分辨率上的优势, 研究默认网络参与睡眠依赖记忆巩固的神经机制。包括:1)发掘默认网络活动的电生理指标, 应用EEG源定位和跨频段耦合分析, 揭示记忆巩固的动态过程; 2)应用滑动时间窗和模块分析, 研究默认网络参与静息态和睡眠过程记忆巩固的异同, 揭示记忆在昼夜更迭中得以强化的神经机制; 3)通过多模态信息融合, 揭示记忆类型和睡眠阶段等因素对睡眠依赖记忆巩固的影响。本研究的开展对阐明睡眠依赖记忆巩固的神经机制具有深刻的理论意义, 并最终可能为治疗学习记忆相关障碍提供全新的思路。 相似文献
730.