汉语加工脑神经机制研究的新进展

随着脑科学研究手段的改进．人们对汉语加工的脑神经机制有了更多、更深入的了解。大量研究表明,汉语加工有不同于拼音语言加工的脑机制,在加工汉语时．激活的脑区和在加工拼音语言时激活的脑区不同．母语为汉语的人和母语为拼音语言的人在脑的形态结构上也存在显著差异。对汉语加工脑机制的研究有利于对音素和音节加工的皮层表征的分离,有助于揭示语言加工脑机制的普遍性和特殊性。     

Using Cognitive Mapping to Understand Problems Experienced by Family Caregivers of Persons with Severe Physical Disabilities

Individuals who provide ongoing care for family members who have a chronic disease or disability are likely to encounter a wide array of problems that can compromise their own health and their ability to function effectively in a caregiving role. Structured focus group meetings were conducted to elicit a comprehensive list of the problems that caregivers experienced during their first year of providing care to a person with a severe physical disability. A separate group of caregivers (N = 60) individually sorted problems into piles based on their similarity and assigned relative importance to each problem. The aggregated data were analyzed with multidimensional scaling and hierarchical cluster analysis. Results indicated that caregivers cognitively organize problems along three dimensions: I. Centeredness–caregiver versus patient-oriented; II. Relationship Demands–physical versus emotional; and III. Caregiver Burden–time versus emotional. Additionally, 6 clusters of substantively similar problems were identified and prioritized in terms of personal relevance: Basic Needs (lowest); Perceived Constraints; Caregiver Challenges; Patient Resentment; Patient Withdrawal; and Patient Intrapsychic Adjustment (highest). Further examination of the organization of problems identified by caregivers should provide important insights about the experience of caregivers and how more targeted interventions can be developed to address their specific needs.     

安全基地启动及其脑机制

近几年,安全基地启动已成为拓展依恋理论的重要实验方法。安全启动能够改善情绪及情绪调节策略、增进人际关系、促进自我实现和利他等。安全启动下,研究者得以考察成人依恋与母婴依恋的神经基础及它们之间的区别与联系。该文分析了安全启动实验的不足,如生态效度和重复率不高,应用范围局限,缺乏启动效应持续性的研究等。未来的安全启动研究应突破现有实验室情境研究局限,拓展应用领域,加强对其心理机制与神经机制的探讨等。     

脑功能磁共振伦理学问题初探

本文概略介绍新兴的脑功能磁共振检查原理及其对人脑运作机制、人类精神活动的研究。讨论脑功能磁共振的临床技术是否完善、现阶段普及该技术是否可能和必要,以及进行脑功能磁共振检查可能引发的隐私权、歧视等伦理学问题,并探讨解决之道。     

原发性甲亢合并严重肝损伤患者的循证治疗

为原发性甲亢合并严重肝损伤患者制定循证治疗方案。根据PICO原则,提出临床问题并转换成便于检索的形式,检索美国国家指南交换中心（NGC）、Cochrane图书馆（2010年第3期）、PubMed（1995-2010．11）和维普数据库（CHKD,1995～2010．11）。根据检索结果,制定治疗方法,2月后患者肝功能、...     

体外循环所致炎性肺损伤机制及保护进展

肺损伤是体外循环心内直视手术的主要并发症之一。肺损伤的机制十分复杂,主要是全身炎性反应和缺血/再灌注损伤所致。肺保护的方法多种多样,其目的是降低全身炎性反应,减轻或避免缺血/再灌注损伤。本文探讨体外循环肺损伤的机制和保护进展。     

脾虚与胃黏膜损伤相关性的理论探讨

本文就脾虚与胃黏膜损伤的相关性从中医发病学、病机关联观、证型归纳属性及治法归类等4个方面,进行了理论探讨。认为中医脾虚的病理状态为胃黏膜损伤提供了客观条件,而胃黏膜损伤因素则又易加重脾虚证候,二者间存在着互为因果的相关关系。其观点为构建“从脾虚论治”胃黏膜损伤性疾病的治则观提供了理论基础。     

中药及其提取物防治血管内皮细胞损伤的研究概况

血管内皮细胞衬覆于血管内膜表面,不仅是血液与血管壁之间的屏障,更是重要的内分泌和效应器官,内皮细胞损伤和功能障碍是动脉粥样硬化发生的启动步骤。近年来的研究表明,中药及其提取物对血管内皮细胞具有保护作用,因此对防治动脉粥样硬化相关疾病有重要的意义。     

循环肿瘤细胞的研究进展

循环肿瘤细胞（circulating tumor cells,CTCs）指自发或因诊疗操作由实体瘤或转移灶释放进入外周血循环的肿瘤细胞。CTCs能被看作液体活检,具有实时监测功能,是一种非侵入性的新型诊断工具,有助于早期发现肿瘤的微转移,可评估预后,在治疗的监测及个体化治疗上具有重要的临床意义。     

Walking dreams in congenital and acquired paraplegia

To test if dreams contain remote or never-experienced motor skills, we collected during 6 weeks dream reports from 15 paraplegics and 15 healthy subjects. In 9/10 subjects with spinal cord injury and in 5/5 with congenital paraplegia, voluntary leg movements were reported during dream, including feelings of walking (46%), running (8.6%), dancing (8%), standing up (6.3%), bicycling (6.3%), and practicing sports (skiing, playing basketball, swimming). Paraplegia patients experienced walking dreams (38.2%) just as often as controls (28.7%). There was no correlation between the frequency of walking dreams and the duration of paraplegia. In contrast, patients were rarely paraplegic in dreams. Subjects who had never walked or stopped walking 4–64 years prior to this study still experience walking in their dreams, suggesting that a cerebral walking program, either genetic or more probably developed via mirror neurons (activated when observing others performing an action) is reactivated during sleep.