Modulation of N400 in chronic non-fluent aphasia using low frequency Repetitive Transcranial Magnetic Stimulation (rTMS)

Low frequency Repetitive Transcranial Magnetic Stimulation (rTMS) has previously been applied to language homologues in non-fluent populations of persons with aphasia yielding significant improvements in behavioral language function up to 43 months post stimulation. The present study aimed to investigate the electrophysiological correlates associated with the application of rTMS through measurement of the semantic based N400 Event-related brain potentials (ERP) component. Low frequency (1 Hz) rTMS was applied to the anterior portion of the homologue to Broca’s area (pars triangularis), for 20 min per day for 10 days, using a stereotactic neuronavigational system. Twelve non-fluent persons with aphasia, 2-6 years post stroke were stimulated. Six participants were randomly assigned to receive real stimulation and six participants were randomly assigned to receive a blind sham control condition. ERP measures were recorded at baseline, 1 week and 2 months subsequent to stimulation. The findings demonstrate treatment related changes observed in the stimulation group when compared to the placebo control group at 2 months post stimulation indicating neuromodulation of N400 as a result of rTMS. No treatment related changes were identified in the stimulation group, when compared to the sham group from baseline to 1 week post stimulation. The electrophysiological results represent the capacity of rTMS to modulate neural language networks and measures of lexical-semantic function in participants with non-fluent aphasia and suggest that time may be an important factor in brain reorganization subsequent to rTMS.     

Stability and Invariance of Psychopathic Traits from Late Adolescence to Young Adulthood

The current study examined the longitudinal stability and invariance of psychopathic traits in a large community sample of male twins from ages 17 to 23. Participants were assessed across 6 years to gauge the stability and measurement invariance of the Minnesota Temperament Inventory (MTI), a Cleckley-based measure of psychopathic personality traits, and how family functioning and externalizing behavior were linked to these traits. A latent variable approach was used to model the structure of the MTI and provide a statistical test of measurement invariance across time. The results revealed support for invariance and moderate to strong stability of the MTI factors, which showed significant associations with the external correlates in late adolescence but not early adulthood.     

Executive Functioning and Delay Discounting of Four Different Outcomes in University Students

The study investigated a potential relationship between level of executive functioning and rates of delay discounting (i.e., the subjective decrease in the value of an outcome if its delivery is delayed). University students completed an executive-functioning questionnaire and then a delay-discounting task involving four different outcomes (money, cigarettes, dating partner, body image). Results showed that the overall measure of executive functioning was a significant predictor of rates of discounting of three of the four outcomes, and approached significance for the fourth outcome. Further, different subscales of executive functioning were significantly correlated with discounting of different outcomes. These results suggest that executive functioning plays a role in discounting of delayed outcomes and that procedures designed to affect either executive function or delay discounting might result in concomitant changes in the other measure.     

The structure of executive functioning in 11 to 14 year olds with and without special educational needs

The structure and development of executive functioning (EF) have been intensively studied in typically developing populations, with little attention given to those with Special Educational Needs (SEN). This study addresses this by comparing the EF structure of 132 adolescents (11–14 years-old) with SEN and 138 adolescents not requiring additional support (Non-SEN peers). Participants completed verbal and non-verbal assessments of key components of EF: inhibition, working memory and switching. Confirmatory Factor Analysis on each group tested one-, two- and three-factor models of EF. In both groups, there was statistical support for the fit of one- and two-factor models with no model being clearly better than the others; there was little support for three-factor models. Parsimony suggests that the one-factor model best represents the structure of EF. In light of our results, the implications for the nature of EF in early adolescence in both SEN and Non-SEN groups are discussed.     

高功能自闭症儿童不同常规度转喻加工的发展：来自ERP的证据

采用ERP技术考察了6~11岁高功能自闭症（HFA）儿童常规和新奇转喻的认知加工过程及发展轨迹。结果显示,6~8岁HFA组和典型发展（TD）组加工常规和新奇转喻的N400波幅无差异,未出现常规度效应,其波幅与错误句也无差异。9~11岁HFA组对新奇转喻N400波幅负于常规转喻,出现常规度效应,常规转喻N400波幅异于错误句,9~11岁TD组常规和新奇转喻均异于错误句。6~8岁HFA组对常规转喻N400差异波负于9~11岁,6~8岁TD组对常规和新奇转喻均负于9~11岁。HFA组转喻N400波幅均负于TD组。结论：HFA儿童常规和新奇转喻的加工较TD儿童存在缺陷。从6岁到11岁,HFA儿童常规转喻加工随年龄增长显著提高,新奇转喻则未出现明显变化,较之常规转喻,新奇转喻的加工尤为困难。     

青少年家庭功能与心理复原力的关系：一个有调节的中介模型

为探讨家庭功能、自我控制与青少年心理复原力的关系及其作用机制,采用家庭功能评定量表、自我控制量表、心理复原力量表对浙江省、山东省、河北省957名中学生进行调查。结果发现：（1）家庭功能对青少年心理复原力具有显著正向预测作用。（2）自我控制在家庭功能和青少年心理复原力之间起到部分中介作用。（3）家庭功能对青少年心理复原力中介过程的前半段路径受到性别调节,相比于女生,男生群体的家庭功能对自我控制的影响更为显著。