Objective: To investigate the efficacy of 3-D printed bone models as a tool to facilitate initiation of bisphosphonate treatment among individuals who were newly diagnosed with osteoporosis.
Design: Fifty eight participants with estimated fracture risk above that at which guidelines recommend pharmacological intervention were randomised to receive either a standard physician interview or an interview augmented by the presentation of 3-D bone models.
Main outcome measures: Participants’ beliefs about osteoporosis and bisphosphonate treatment, initiation of bisphosphonate therapy assessed at two months using self-report and pharmacy dispensing data.
Results: Individuals in the 3-D bone model intervention condition were more emotionally affected by osteoporosis immediately after the interview (p = .04) and reported a greater understanding of osteoporosis at follow-up (p = .04), than the control group. While a greater proportion of the intervention group initiated an oral bisphosphonate regimen (alendronate) (52%) in comparison with the control group (21%), the overall initiation of medication for osteoporosis, including infusion (zoledronate), did not differ significantly (intervention group 62%, control group 45%, p = .19).
Conclusion: The presentation of 3-D bone models during a medical consultation can modify cognitive and emotional representations relevant to treatment initiation among people with osteoporosis and might facilitate commencement of bisphosphonate treatment. 相似文献
Generate a human organ in an animal in order to elaborate a stock of available organs for transplantation… This is not the scenario of a science fiction movie but the result of the hard work of some researchers convinced of the feasibility of this major innovation. If the interest of this discovery is undeniable, it generates also many ethical and legal questions. 相似文献
Goodman's (1979, 1981, 1985) loglinear formulation for bi-way contingency tables is extended to tables with or without missing cells and is used for exploratory purposes. A similar formulation is done for three-way tables and generalizations of correspondence analysis are deduced. A generalized version of Goodman's algorithm, based on Newton's elementary unidimensional method is used to estimate the scores in all cases.This research was partially supported by National Science and Engineering Research Council of Canada, Grant No. A8724. The author is grateful to the reviewers and the editor for helpful comments. 相似文献
Abstract : A Lutheran bioethics must rest on a reconstructed version of Martin Luther's ethics. In the article it is shown that this ethics is Christian in that it has faith in Jesus Christ as its source. But the ethics of neighbor love is practiced in the secular world where it to some extent corresponds with natural law ethics. A Christian believer acts ethically both as an individual and as a citizen. Against the background of this understanding of Lutheran ethics, the position of Ted Peters and Gilbert Meilaender on genetics and stem cells is presented and criticized. One conclusion is that there is no Lutheran doctrine on the status of the human embryo. 相似文献