骨源性因子ucOCN在运动抗抑郁中的作用机制

羧化不全骨钙素(ucOCN)是骨中成骨细胞分泌的特异性蛋白,因其在调控神经发育、神经可塑性等中的重要角色而受到神经科学领域关注。"骨-脑"串联"对话"是骨内分泌-神经介导的应答系统,ucOCN透过血脑屏障后介导单胺类神经递质、神经内分泌、神经免疫、神经再生及基因表达等机制,进而作用于海马CA3区、扣带回等脑区功能发挥来调节抑郁发生及改善。而ucOCN作为骨源性力学刺激敏感基因,运动上调其表达后进入血液循环,通过介导5-HT/GABA分泌、HPA轴功能、炎症反应、神经营养因子(BDNF等)表达或信号途径(如GSK3β/β-catenin、TLR4/miR-223/NLRP3等)激活等来实现"骨串联脑",发挥运动抗抑郁作用。通过对骨源性因子ucOCN介导脑区功能变化从而实现运动抗抑郁的作用机制进行探讨、梳理,一方面有助于更深入了解骨内分泌功能,另一方面为抑郁发生、改善和运动抗抑郁研究提供新的理论基础和研究思路。     

甲骨文所见医疾资料研究综论

甲骨文中保存了目前所见最早的医疾资料,引起了古文字学家、历史学家、中医学者的共同关注,产生了非常丰富的研究成果。目前,关于甲骨文医疾资料的研究,主要集中在甲骨文医疾资料数量、病症名称、致病原因、诊疗方法等几个方面;以往研究中存在释字不确、观点更新滞后、对卜辞语句理解欠准确、过度解读等问题,应引起学界的重视。甲骨文医疾资料的研究当以准确识文断字为前提,其研究具有跨学科性,古文字学、中医学等相关学科的交叉合作有助于推进甲骨文医疾资料的纵深研究。

     

基于扎根理论的志愿者遗体（器官）捐献的动力探索

在濒临死亡情境下,对26名遗体（器官）捐献志愿者进行深度访谈并收集资料,运用扎根理论的开放编码、关联编码及选择编码对原始资料进行分解、检测、比较、概念化及类属化,并围绕志愿者遗体（器官）捐献的动力进行理论编码。结果显示,构建了扎根于原始资料的志愿者遗体（器官）捐献的新利他主义动机心理模型,形成了正确生死观构筑志愿者遗体（器官）捐献的认识基础、追寻意义存在构建志愿者遗体（器官）捐献的心理特征及利他主义新理念成为志愿者遗体（器官）捐献的动力三条新理论,对诠释志愿者遗体（器官）捐献行为具有一定参与价值。

     

L’annonce d’un décès en milieu hospitalier

Announcing a death is always a delicate moment for close familial members but also for caregivers. Law gives some precisions about how this information must be delivered. Recently the state council judged that the lack of empathy from caregivers and the late of the death announcement can create a damage. This judgement gives more precisions about how a death announcement must be in a hospital. This topic is pretty similar with the information which must be given to close familial members about organ donation. This latter is definitely more exceptional and the procedure is a way more regulated. There are much rules which explain how this information must be delivered.     

THE INTERPLAY BETWEEN RELIGIOUS LEADERS AND ORGAN DONATION AMONG MUSLIMS

Bioethics and health researchers often turn to Islamic jurisconsults (fuqahā’) and their verdicts (fatāwā) to understand how Islam and health intersect. Yet when using fatwā to promote health behavior change, researchers have often found less than ideal results. In this article we examine several health behavior change interventions that partnered with Muslim religious leaders aiming at promoting organ donation. As these efforts have generally met with limited success, we reanalyze these efforts through the lens of the theory of planned behavior, and in light of two distinct scholarly imperatives of Muslim religious leaders, the ?ilmī and the islāhī. We argue for a new approach to health behavior change interventions within the Muslim community that are grounded in theoretical frameworks from the science of behavior change, as well the religious leadership paradigms innate to the Islamic tradition. We conclude by exploring the implications of our proposed model for applied Islamic bioethics and health research.     

Enactments of Race in the UK’s Blood Stem Cell Inventory

Recent sociological analyses of the intersections of race and science recognise race’s quality as an enacted object. Through this analytic lens, race is always materialising in the practices and processes that enrol it and therefore enjoys a kind of multiplicity. The context of blood stem cell transplantation, a scientific domain marked by a more and less explicitly racialised logic, offers an opportunity to see the conceptual assertion of race’s multiplicity play out. Indeed, an exploration of the UK’s stem cell inventory reveals—through analysis of interviews, policy and parliamentary meetings—how race materialises in the various practices that comprise this increasingly popular cancer treatment option. Looking at practices of recruitment, inventory management and tissue selection in particular provides an interesting window to look upon race and the many signifiers that implicate it. These cases reveal moments of race’s stablisation and silencing; its oscillation between the status of vital information to the life of a public stem cell inventory, and of secondary data that provides little useful information to clinicians selecting tissue. Adopting an analytic lens that attends to race’s multiple enactments allows us to begin asking why enactments take the shape they do, and why the particular practices that mobilise them come to be.     

骨延长的骨愈合原理

骨延长愈合与骨折愈合等多种多样的骨修复现象可能具有相同的细胞生物学基础,这个理论称为骨修复一元论.血管内皮细胞是启动骨修复的感受器,破骨细胞通过分泌骨形态发生蛋白（BMP）启动骨特异性修复.骨折间隙间断性的力学脉冲通过血管内皮细胞不断地转化为骨修复的生物学脉冲.在微损伤条件下,骨修复具有放大效应.保护下负重和功能锻炼是下肢骨骼延长术后的重要原则.     

治疗感染性骨不连伴大段骨缺损的探讨与思考

感染性骨不连伴大段骨缺损是目前临床骨科较为常见、多发、治疗极为棘手的病种之一,治疗方法多种多样,但疗效却不理想,且缺乏统一的诊治与疗效判断标准,总结、分析几种临床上主要治疗方法的利弊,为该病探寻一条微创、安全、并发症少及疗效确切的可靠治疗方法.随着对Ilizarov技术的基础与临床研究的不断深入,该技术在治疗传统方法难以治愈的疾病如四肢关节严重畸形、感染性骨不连或伴有骨缺损、皮肤软组织缺损等方面显示出自身的优势,为治疗疑难骨科疾病开辟了一条新的有效途径.     

我国公民逝世后器官捐献工作影响因素分析

探讨我国公民逝世后器官捐献工作的影响因素,为提高器官捐献率,推动器官捐献事业的发展,提供决策参考。通过文献查阅等方法,从政治、经济、社会和技术四个方面对影响公民逝世后器官捐献工作的因素进行深入分析。器官捐献与移植工作是一项系统工程,影响因素众多,为做好器官捐献与移植工作,需要政府、医疗机构和社会公众等多方面的努力和配合,从政治、经济、社会、技术等多个层面采取针对性的策略,以进一步提高器官捐献成功率。     

“达”则兼济天下?社会比较对亲社会行为的影响及心理机制

本文通过两个研究探讨社会比较对亲社会行为的影响及其内在机制。研究一中,被试被随机要求与学习成绩排名第一或者最后的人相比,然后测量其助人倾向。结果发现,与向上比较组和控制组相比,向下社会比较会提高个体的助人倾向。研究二通过虚构的智力测验排名反馈操纵社会比较,然后测量被试的捐款意愿。结果发现,得知测验成绩比大多数人好的时候,人们更愿意捐款。两个实验共同表明,社会比较对亲社会行为的影响由个体对弱势群体的同理心所中介。