根据血压昼夜节律选择服药时间控制血压晨峰

根据血压昼夜节律,观察给药时间对血压晨峰的影响。256例原发性高血压患者,经24h动态血压监测分为超杓型（n＝49）、杓型（n＝127）和非杓型（n＝80）3组;各组再分为清晨服药组和晚上服药组。用药6周,比较用药前后血压昼夜节律及血压晨峰的变化,发现在改变血压昼夜节律及降低血压晨峰方面,超杓型组清晨服药优于晚上服药,非杓型组晚上服药优于清晨服药;杓型组清晨服药与晚上服药均能降低晨峰值,提示根据个体血压昼夜节律选择服药时间能更好地控制血压晨峰。     

Cerebral blood flow in 5‐ to 8‐month‐olds: Regional tissue maturity is associated with infant affect

Infancy is marked by rapid neural and emotional development. The relation between brain function and emotion in infancy, however, is not well understood. Methods for measuring brain function predominantly rely on the BOLD signal; however, interpretation of the BOLD signal in infancy is challenging because the neuronal‐hemodynamic relation is immature. Regional cerebral blood flow (rCBF) provides a context for the infant BOLD signal and can yield insight into the developmental maturity of brain regions that may support affective behaviors. This study aims to elucidate the relations among rCBF, age, and emotion in infancy. One hundred and seven mothers reported their infants' (infant age M ± SD = 6.14 ± 0.51 months) temperament. A subsample of infants completed MRI scans, 38 of whom produced usable perfusion MRI during natural sleep to quantify rCBF. Mother‐infant dyads completed the repeated Still‐Face Paradigm, from which infant affect reactivity and recovery to stress were quantified. We tested associations of infant age at scan, temperament factor scores, and observed affect reactivity and recovery with voxel‐wise rCBF. Infant age was positively associated with CBF in nearly all voxels, with peaks located in sensory cortices and the ventral prefrontal cortex, supporting the formulation that rCBF is an indicator of tissue maturity. Temperamental Negative Affect and recovery of positive affect following a stressor were positively associated with rCBF in several cortical and subcortical limbic regions, including the orbitofrontal cortex and inferior frontal gyrus. This finding yields insight into the nature of affective neurodevelopment during infancy. Specifically, infants with relatively increased prefrontal cortex maturity may evidence a disposition toward greater negative affect and negative reactivity in their daily lives yet show better recovery of positive affect following a social stressor.     

An exploratory analysis of the influence of personality and emotional factors on cerebral blood flow responses during painful stimulation in Fibromyalgia

This study explored the influence of certain personality traits (neuroticism, extraversion, psychoticism, alexithymia), emotional variables (depression, catastrophizing), and insomnia on cerebral blood flow (CBF ) responses to painful stimulation in fibromyalgia, using functional transcranial Doppler sonography. CBF velocities were recorded bilaterally in the anterior cerebral arteries (ACA ) and middle cerebral arteries (MCA ) of 24 fibromyalgia patients during exposure to two painful pressure conditions: (1) fixed pressure (2.4 kg) and (2) an individually calibrated pressure to produce an equal‐moderate subjective pain intensity in all participants (average, 3.5 kg). Psychological factors were assessed by means of questionnaires. Neuroticism, and the externally‐oriented thinking dimension of alexithymia were positively, and extraversion was inversely, associated with specific components of ACA and MCA CBF responses. Regarding catastrophizing and depression, correlations were positive for the fixed pressure condition and negative for the equal subjective intensity condition. The findings suggest that alterations in central nervous pain processing in fibromyalgia vary according to psychological factors. While most of the observed associations reflect a linear increase in nociceptive processing with the magnitude of negative cognitive and emotional states, the inverse associations for catastrophizing and depression during more intense painful stimulation may be ascribed to anti‐nociceptive effects due to activation of the defense reflex.     

The Construct Validity of the Work-Related Flow Inventory in a Sample of Australian Workers

The purpose of this study was to examine the construct validity of the WOrk-reLated Flow inventory (WOLF; Bakker, 2008). This instrument was administered to 711 men and women who were working in Queensland, Australia. The results from the confirmatory factor analysis showed that the WOLF has moderately acceptable construct validity, with the three-factor model being a borderline fit to the data. Tests of the convergent validity of the WOLF yielded satisfactory results. However, the analysis of the discriminant validity of the WOLF showed that the instrument poorly discriminated between work enjoyment and intrinsic work motivation. Follow-up exploratory factor analysis, using recommended procedures for determining the number of factors to extract, revealed a two-factor solution, with the work enjoyment and intrinsic work motivation items loading on the same factor. Drawing on literature on psychological flow and motivation, as well as the findings of the present study, questions are raised over the adequacy of the conceptual basis of the three-factor model of work-related flow, the discriminant validity of the WOLF subscales, and the appropriateness of the wording of several of this measure's items. Using alternative methods and measures to investigate flow in work settings is recommended.     

Hemodynamic responses to active and passive coping tasks and the prediction of future blood pressure in Thai participants: A preliminary prospective cohort study

Cardiovascular responses to mental stress tests have been related to future blood pressure (BP) levels. However, most studies have been completed in North America and Europe; only one study has been conducted in Asia. Therefore, the study explored whether cardiovascular responses to mental stress predict future resting BP in Thailand. Hemodynamic measures were obtained from 101 healthy adults before, during and after mental arithmetic, a speech task, and a cold pressor task. A follow‐up assessment of resting BP was undertaken 1 year later. Results showed that Thais responded to standardized mental stress tasks with large and significant cardiovascular reactivity. Regression analyses indicated that, after adjustment for baseline BP and traditional risk factors, heightened systolic blood pressure (SBP) responses to mental arithmetic were associated with increased future SBP (ΔR² = .045). These findings suggest that BP reactivity predicts future BP and may play a role in the development of hypertension. In addition, Thais displayed large cardiovascular responses to standardized mental stress tasks, of a similar magnitude to previous studies of North Americans and Europeans.     

The role of teammate relationships,communication and self-efficacy in predicting athlete flow experience

This study aimed at testing a structural model of athlete flow in a sample of South African students. A quantitative, cross-sectional research design was implemented. Participants completed self-report measures at pre-arranged times that were in close proximity to the completion of athletic activity. Student athletes (n = 235) participating in South Africa's two major sports, football and rugby, were surveyed. The instruments utilised in this study included the Short Flow State Scale-2, the Questionnaire on Experience and Assessment of Work, and the Generalised Self-Efficacy Scale. The results indicated positive relationships between the variables and established predictor paths. Teammate relationships and self-efficacy were established to as the best predictors of flow experiences of athletes.     

Does cardiovascular reactivity during speech reflect self-construction processes?

Abstract

Substantial empirical research has been undertaken on cardiovascular reactivity (CVR). however interpretation of this research is hampered by a lack of theoretical frameworks. This paper develops a framework initially stimulated by evidence demonstrating that the cardiovascular system increases in activity during communication, and that the extent of this activation depends upon numerous and diverse psychosocial factors. We attempt to account for this phenomenon using merit post-structuralist ideas concerning the constructive nature of language and its centrality to an individual's sense of self. Our theoretical framework proposes that the CVR exhibited during language use is explicable in terms of self-construction - From this analysis we hypothesised that CVR would differ across conversations about private self. public self and non-self topics, and that these differences would depend upon people's speaking histories. We found that the blood pressure and heart rate of 102 women was most reactive when they talked in a laboratory with a stranger about aspects of their private self, and least reactive during non-self talk, whilst their heart rate was most reactive during talk about their public self. Overall the results highlight the inextricable link between our inherent socialness and our cardiovascular systems.

SUMMARY

The explanatory scheme outlined here is an attempt to provide a social reconceptualisation of a phenomenon that is typically interpreted in individualistic psychophysiological terms, and which is consistent with the notion that repeated exposure to situations which provoke large haemodynamic changes may lead to CHD disease progression. The explanation draws heavily on post-structuralist ideas regarding language, and the social constructionist notion that engaging in language use is central to constructing and maintaining a sense of self. This sense of self is a central theoretical entity in our everyday lives, produced and maintained in our interactions with others. We argue that it is this centrality of self-construction that helps to explain the extraordinary consistency of elevated CVR in conversation. Further, we have noted the striking parallels between those features of conversations that make the self salient, and those that have been associated with elevated CVR. To examine it more explicitly, it needs to be tested empirically with new data, using explicitly derived operationalisations and hypotheses.     

大连某医院体检人群血脂四项的调查分析

对大连地区健康成人血清总胆固醇（TC）、血清甘油三脂（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）进行调查研究.选取2009年4月至2010年12月大连地区16 052名健康体检者,并按性别和年龄分组.早晨空腹,采集所有调查对象3ml肝素抗凝血,用日立7060全自动生化分析仪检测血清TC、TG、HDL-C和LDL-C的结果.结果大连地区健康成人血脂水平比2007年发表的中国成人血脂异常防治指南所确定的正常参考区间偏高,因此,我们对大连地区人们的血脂水平必须引起高度重视,以预防和减少高脂血症及其相关疾病的发生.     

The Influence of Attitude on Learning

Automaticity theory and the effect of coloring a single element were tested with all or only 1 element colored in Stroop tasks. The 312 participants in 5 experiments indicated stimulus presentation color by key press. Experiments 1 and 2 replicated those of D. Besner, J. A. Stoltz, and C. Boutilier (1997) with some changes, and revealed similar results: less Stroop interference with only 1 letter colored. Besner et al. (1997) interpreted the results as indicating that coloring a single letter eliminates automatic reading processes. The cause of that reduction in Stroop interference was investigated in Experiments 3, 4, and 5 using color words, bars, and rectangles. The effect of coloring 1 element was to increase color-naming time by the same amount for congruent and neutral, nonverbal stimuli, but not for incongruent stimuli. The results are interpreted in terms of automaticity theory, and a continuous flow approach to the Stroop effect is presented.     

Postural Requirements and Progression Velocity in Young Walkers

This article describes developmental changes in gait velocity and relates these changes to gait parameters that index postural stability (step width and lateral acceleration) and two components of velocity (cadence and step length).

Five children were observed longitudinally over a 2-year period after onset of independent walking. Their range of speed increased threefold in the first 6 months of independent walking and then remained constant. In contrast, step width decreased approximately twofold. Whereas in adults, cadence and step length contribute approximately equally to speed, when infants first begin to walk independently, increase in velocity is due mostly to increased step length. After 5 months of independent walking, the pattern reverses, and increase in velocity is due primarly to increased cadence. The pattern remains constant over the next 18 months. From a developmental point of view, the data lead us to interpret early walking (the first 5 months) as a process of integration of postural constraints into the dynamic necessities of gait movement. A second phase, beginning after 4 to 5 months of independent walking, is considered to be a tuning phase characterized by a more precise adjustment of the gait parameters.