Avoidant coping in panic disorder: a yohimbine biological challenge study

Abstract

Few studies have addressed whether the use of avoidance-oriented coping strategies is related to the development of panic in patients with panic disorder(PD). Self-report, clinician-rated, and physiological data were collected from 42 individuals who participated in a yohimbine biological challenge study, performed under double-blind, placebo-controlled conditions. Participants included 20 healthy controls and 22 currently symptomatic patients who met DSM-IV-TR diagnostic criteria for PD. Consistent with prediction, patients with PD who had higher perceived efficacy of avoidance-oriented strategies in reducing anxiety-related thoughts reported increased severity in panic symptoms during the yohimbine challenge condition as compared to the placebo. Further, patients with PD who had more fear of cognitive dyscontrol, cardiovascular symptoms, and publicly observable anxiety also reported increased severity in panic symptoms during the challenge. Healthy controls who had more fear of cardiovascular symptoms similarly reported increased severity in panic symptoms during the challenge. No effects were found for heart rate response to the challenge agent. These results provide support for the role of avoidance-oriented coping strategies and fear of anxiety-related symptoms as risk and maintenance factors in the development of panic symptoms, particularly within a biological challenge model.     

Temporal binding during apparent movement of the human body

Alternating between static images of human bodies with an appropriate interstimulus interval (ISI) produces apparent biological motion. Here we investigate links between apparent biological motion and time perception. We presented two pictures of the initial and final positions of a human movement separated by six different ISIs. The shortest movement path between two positions was always biomechanically impossible. Participants performed two tasks: In an explicit task, participants judged whether they saw the longer, feasible movement path between the two postures, or the shorter, biomechanically impossible path. In an implicit task, participants judged the duration of a white square surrounding the picture sequence. At longer ISIs participants were more likely to see a longer, feasible movement path (explicit task) and underestimated the duration of body picture pairs, compared to trials displaying degraded body pictures (implicit task). We argue that perceiving apparent biological motion involves temporal binding of two static pictures into a continuous movement. Such temporal binding may be mediated by a top-down mechanism that produces a percept of biological motion in the absence of any retinal motion.     

Naturism as a Form of Religious Naturalism

The version of religious naturalism sketched here is called naturism to distinguish it from conceptions of religious naturalism that make fundamental appeal to some idea of deity, deities, or the divine, however immanental, functional, nonontological, or purely valuational or existential such notions may be claimed to be. The focus of naturism is on nature itself as both metaphysically and religiously ultimate. Nature is sacred in its own right, not because of its derivation from some more–ultimate religious principle, state, being, beings, or order of being. Humans, their cultures, and their histories are conceived as integral parts of nature, manifestations of potentialities that lie within it and have been actualized by biological evolution. While there is no purpose of nature, the natural order contains beings capable of purposive behavior. With this purposive behavior, and the goals and ideals implicit in it, humans have the capacity to give significant direction to their ongoing cultural evolution and to discover and maintain their appropriate place within the community of creatures.     

双螺旋的发现与生物学的统一

双螺旋的发现和遗传密码的破译是20世纪激动人心的大事。在生物学的这个发展过程中,洛克菲勒基金会对应用物理学方法研究分子生物学问题的资助以及大批物理学家向生物学的转移对分子生物学的发展起到了重要的推动作用。选择战略性的课题,善于学习和鉴别已有的研究成果,站在巨人的肩上,是沃森和克里克成功的关键。双螺旋的发现不仅揭示了遗传的奥秘,而且促进了生物学的统一。     

Implications of MDMA use for prospective memory function and substance use patterns in an Australian sample: A web‐based pilot study

The use of amphetamine type stimulants, particularly MDMA, is a global concern. Little research has been conducted on the association between MDMA use and everyday memory function—prospective memory. Twenty‐five MDMA users, 37 cannabis users, and 43 illicit substance‐naïve controls were assessed on their substance use history and reported prospective memory performance as measured by the Prospective Memory Questionnaire (PMQ) using a web‐based survey. There were significant differences between MDMA users and controls and cannabis users and controls on long‐term episodic subscale of the PMQ. However, given the high prevalence of cannabis co‐use by MDMA users, it was not possible to determine if MDMA use alone is associated with prospective memory performance. The substance use patterns of the sample were evaluated. Alcohol was the most used substance followed by tobacco, cannabis, and MDMA. The incidence of polydrug use was high, with all illicit substance use reporting having used at least two substances in their lifetime. The present study supports previous research into prospective memory deficits associated with substance use, and provides a basis for future research, particularly for elucidation of prospective memory deficits specific to MDMA use and further evaluation of substance use patterns.     

How people familiarize themselves with complex ecological concepts—anchoring of social representations of invasive non‐native species

New terms and frameworks are constantly being incorporated into scientific and public discourses on the management of natural resources and the environment. The idea of invasive non‐native plant and animal species, i.e. of species that enter a new range and spread prolifically, is currently becoming part of the public discourse in Scotland. This constitutes a valuable opportunity to study how people engage with new scientific concepts. We analysed focus group and personal interview data to examine how participants (including the general public, conservation volunteers and scientists) familiarized themselves with the ecological concept of invasive non‐native species. Our analysis draws on the idea of anchoring in the formation of social representations, complemented by concepts from cognitive linguistics and conceptual blending, and defines anchoring as a process of information transfer from source to target domains. Our findings suggest that social representations of invasive non‐native species were constituted to a large degree by perceptions of species' detrimental impacts and the human role in and responsibility for the introduction process. By contrast, the non‐nativeness of a species was not relevant for participants from the general public and conservation volunteers. Three types of anchoring could be distinguished in our participants' discussions that differed with regard to the relations between source and target domain. Whereas participants from the general public and conservation volunteers used all three types of anchoring, scientists did not. The identification of different anchoring types also helped to explain incongruencies in the scientific discourse on invasive non‐native species, and has implications for public information campaigns. Copyright © 2010 John Wiley & Sons, Ltd.     

Analyse des prélèvements biologiques médico-légaux : quel cadre juridique à l’ère de la qualité?

Medico-legal autopsy sometimes requires the use of the Parasitology-Mycology specialty. Two recent medico-legal clinical cases, involving this specialty, have questioned us. First of all, may a non-conformity biological analytical (compared to accepted and accredited standards by COFRAC) fail the whole biological expertise, and thereafter, the medico-legal expertise of the file? The answer must consider that the raw result obtained as a result of a medical biology technique must be interpreted and discussed by the expert in the discipline (in this case by the parasitologist) before being included in the medical discussion and discussed by the medical examiner. The judgment is secondarily delivered by the judge according to his intimate conviction and without determining the probative value of the examination. Should a post-mortem biological examination be part of an expertise in medical biology or is it a technical and scientific examination? This answer is based on the previous one, considering the significant contribution of the expert who will bring his knowledge, interpreting and discussing the raw result. A simple technical and scientific examination would only provide the raw result without any assessment of the context and circumstances of the biological sample.     

Do children think that inheritance determines height and weight?

Three studies were conducted to investigate if children think that physical growth is determined by inheritance. All three studies employed the “switched‐at‐birth” task. Study 1 investigated if children and adults thought that height and weight were determined by parentage. Study 2 examined preschoolers and elementary school children's and adults' understanding of the role of parentage and nutrition in determining weight. Study 2a examined children's and adults' understanding of the role of parentage and nutrition in determining height. Results indicate that overall, preschoolers and third graders have more of an inheritance bias for height than for weight. However, when nutrition was introduced, apart from third graders, all other grades reasoned that nutrition played a greater role in determining weight. Overall, these results indicate that even young children have a rudimentary but differentiated theory of the role of inheritance in determining height and weight.

Highlights

• Participants were presented with switched‐at‐birth tasks to determine if they thought that parentage and/or nutrition influences height and weight.
• Young children viewed height as determined more by parentage than weight, suggesting that they have a differentiated and autonomous theory for the determination of height.

     

睡眠拖延行为背后的心理生理机制解析

摘 要 睡眠拖延行为是健康行为拖延领域提出的一个新概念,其可概括为在没有外部原因阻碍的情况下,仍无法在预定时间上床睡觉的现象。目前的研究认为睡眠拖延行为是导致普通人群睡眠不足的重要原因,睡前日常活动及沉浸式活动常常诱导其发生,探讨其背后机制主要涉及自我调节和生物节律两大因素。利用时限性自我调节理论可尝试解析睡眠拖延行为的发生过程。未来研究可从其神经机制探讨及预防和干预措施等方面尝试展开。     

1940年日本细菌战引发的农安长春鼠疫考——基于731部队解密资料的研究

1940年6月～11月,农安长春鼠疫流行。虽有部分文献和档案记录了这场鼠疫流行,然而关于鼠疫流行原因、过程及相关问题却并不十分清楚。在对已有文献梳理基础上,通过对731部队解密科学研究报告的解读分析发现,1940年农安长春鼠疫始于日军细菌战“谋略”,是与浙江细菌战同时进行的细菌战研究,农安鼠疫是细菌战基础研究,浙江细菌战则是实战模型,目的是对鼠疫细菌战剂的播撒方式及其杀伤力进行检测,为寻找有效的细菌武器提供科学依据。1940年农安长春鼠疫是其细菌战研究中的重要节点。