Avoidant coping in panic disorder: a yohimbine biological challenge study

Abstract

Few studies have addressed whether the use of avoidance-oriented coping strategies is related to the development of panic in patients with panic disorder(PD). Self-report, clinician-rated, and physiological data were collected from 42 individuals who participated in a yohimbine biological challenge study, performed under double-blind, placebo-controlled conditions. Participants included 20 healthy controls and 22 currently symptomatic patients who met DSM-IV-TR diagnostic criteria for PD. Consistent with prediction, patients with PD who had higher perceived efficacy of avoidance-oriented strategies in reducing anxiety-related thoughts reported increased severity in panic symptoms during the yohimbine challenge condition as compared to the placebo. Further, patients with PD who had more fear of cognitive dyscontrol, cardiovascular symptoms, and publicly observable anxiety also reported increased severity in panic symptoms during the challenge. Healthy controls who had more fear of cardiovascular symptoms similarly reported increased severity in panic symptoms during the challenge. No effects were found for heart rate response to the challenge agent. These results provide support for the role of avoidance-oriented coping strategies and fear of anxiety-related symptoms as risk and maintenance factors in the development of panic symptoms, particularly within a biological challenge model.     

Evaluating the Relationship Between Childhood Abuse and Neglect,Interpersonal Hostile-Dominance,and Aggression in Psychiatric Hospitals

This study examined whether interpersonal hostile-dominance (HD) mediated the relationship between childhood trauma and aggression in 200 psychiatric inpatients (M age = 38.32 years, 66% male). Childhood emotional (50.5%), physical (42.0%), and sexual (42.0%) abuse, and emotional (46.5%) and physical (41.0%) neglect of moderate to extreme severity was reported. More severe emotional, physical, and sexual abuse, and physical neglect in childhood were associated with higher HD. Higher levels of HD and all forms of childhood abuse and neglect were associated with aggression; HD mediated the relationship between childhood emotional abuse, sexual abuse, and physical neglect and aggression. Findings highlight the high prevalence of childhood trauma in adult psychiatric inpatients. Further, childhood trauma contributes to HD, which increases the risk of aggression.     

Temporal binding during apparent movement of the human body

Alternating between static images of human bodies with an appropriate interstimulus interval (ISI) produces apparent biological motion. Here we investigate links between apparent biological motion and time perception. We presented two pictures of the initial and final positions of a human movement separated by six different ISIs. The shortest movement path between two positions was always biomechanically impossible. Participants performed two tasks: In an explicit task, participants judged whether they saw the longer, feasible movement path between the two postures, or the shorter, biomechanically impossible path. In an implicit task, participants judged the duration of a white square surrounding the picture sequence. At longer ISIs participants were more likely to see a longer, feasible movement path (explicit task) and underestimated the duration of body picture pairs, compared to trials displaying degraded body pictures (implicit task). We argue that perceiving apparent biological motion involves temporal binding of two static pictures into a continuous movement. Such temporal binding may be mediated by a top-down mechanism that produces a percept of biological motion in the absence of any retinal motion.     

The Getting and Losing Wisdom

SUMMARY

The role of aging and culture in the attainment of wisdom is examined m this chapter. The concept of wisdom m industrialised societies is briefly explored. It is argued that both biology and culture can be positive or negative factors m the capacity of a person to be “wise.” It is concluded that, for many, the negative impact of biological factors of aging are overwhelming, but, for a few, aging enriches their insight.     

计算精神病学：抑郁症研究和临床应用的新视角

抑郁症是一种复杂而异质的精神疾病, 给全球带来沉重的疾病负担。尽管基于症状学的诊断方法已被广泛应用于各领域, 但这种方法并不利于病理机制的探讨。另外, 该诊断方法预测效度较低, 导致其难以准确评估和比较各种治疗方案的疗效。计算精神病学方法则能通过理论驱动和数据驱动两种互补的方法解决上述问题, 从而提高对抑郁症的认识、预防和治疗。理论驱动方法基于经验知识或假设, 利用计算建模方法对数据进行多水平分析; 数据驱动方法则基于机器学习算法分析高维数据, 提高抑郁症诊断和预测的准确性, 进而提高治疗的精准度。理论驱动和数据驱动方法的发展与结合, 以及人才和资源的整合, 将会更有效地推进抑郁症的防治。     

The Biology of Morality

Abstract. The morality of human beings, defined here as our ability to determine whether our actions are right or wrong, depends not just on following rules but also on understanding the impact of our actions on another person. How we understand the impact of our actions on another person depends on our state of consciousness, which is mediated by our brain and nervous system. We describe how we understand our morality to flow naturally from the biological state we are living in and how we see our biology and our morality as mutually interactive. A change in one changes the other. Another way of saying this is that changing either our morality or our biology changes both—changes who we are and what we do.     

Naturism as a Form of Religious Naturalism

The version of religious naturalism sketched here is called naturism to distinguish it from conceptions of religious naturalism that make fundamental appeal to some idea of deity, deities, or the divine, however immanental, functional, nonontological, or purely valuational or existential such notions may be claimed to be. The focus of naturism is on nature itself as both metaphysically and religiously ultimate. Nature is sacred in its own right, not because of its derivation from some more–ultimate religious principle, state, being, beings, or order of being. Humans, their cultures, and their histories are conceived as integral parts of nature, manifestations of potentialities that lie within it and have been actualized by biological evolution. While there is no purpose of nature, the natural order contains beings capable of purposive behavior. With this purposive behavior, and the goals and ideals implicit in it, humans have the capacity to give significant direction to their ongoing cultural evolution and to discover and maintain their appropriate place within the community of creatures.     

双螺旋的发现与生物学的统一

双螺旋的发现和遗传密码的破译是20世纪激动人心的大事。在生物学的这个发展过程中,洛克菲勒基金会对应用物理学方法研究分子生物学问题的资助以及大批物理学家向生物学的转移对分子生物学的发展起到了重要的推动作用。选择战略性的课题,善于学习和鉴别已有的研究成果,站在巨人的肩上,是沃森和克里克成功的关键。双螺旋的发现不仅揭示了遗传的奥秘,而且促进了生物学的统一。     

Implications of MDMA use for prospective memory function and substance use patterns in an Australian sample: A web‐based pilot study

The use of amphetamine type stimulants, particularly MDMA, is a global concern. Little research has been conducted on the association between MDMA use and everyday memory function—prospective memory. Twenty‐five MDMA users, 37 cannabis users, and 43 illicit substance‐naïve controls were assessed on their substance use history and reported prospective memory performance as measured by the Prospective Memory Questionnaire (PMQ) using a web‐based survey. There were significant differences between MDMA users and controls and cannabis users and controls on long‐term episodic subscale of the PMQ. However, given the high prevalence of cannabis co‐use by MDMA users, it was not possible to determine if MDMA use alone is associated with prospective memory performance. The substance use patterns of the sample were evaluated. Alcohol was the most used substance followed by tobacco, cannabis, and MDMA. The incidence of polydrug use was high, with all illicit substance use reporting having used at least two substances in their lifetime. The present study supports previous research into prospective memory deficits associated with substance use, and provides a basis for future research, particularly for elucidation of prospective memory deficits specific to MDMA use and further evaluation of substance use patterns.     

Making Meaning of the September 11 Attacks: Spanish- and Mandarin-Speaking Focus Groups

This article examines experiences and perceptions related to the September 11, 2001, attacks among members of two immigrant groups (Spanish-speaking and Mandarin-speaking) in New York City. Focus groups were conducted 1–2 years after the attacks. Qualitative analysis was conducted using ATLAS.ti. Three major themes emerged: (a) Immediate Experience of the Attacks, (b) Evolving Psychological Adjustment, and (c) Long-Term Issues of Public Concern. The groups’ discussions diverged with temporal progression across these themes, reflecting increasing congruence with broad conceptualizations of their respective cultures. The findings suggest that, over time, culture increasingly influenced the meaning these people made of the disaster.