The Cards that are Dealt You

Various philosophers have argued that in order to be morally responsible, we need to be the "ultimate sources' of our choices and behavior. Although there are different versions of this sort of argument, I identify a "picture' that lies behind them, and I contend that this picture is misleading. Joel Feinberg helpfully suggested that we scale down what might initially be thought to be legitimate demands on "self-creation,' rather than jettison the idea that we are truly and robustly responsible. I follow Feinberg in rejecting various "inflated' demands on "origination,' "initiation,' or ultimate sourcehood.     

Patenting humans: Clones,chimeras, and biological artifacts

The momentum of advances in biology is evident in the history of patents on life forms. As we proceed forward with greater understanding and technological control of developmental biology there will be many new and challenging dilemmas related to patenting of human parts and partial trajectories of human development. These dilemmas are already evident in the current conflict over the moral status of the early human embryo. In this essay, recent evidence from embryological studies is considered and the unbroken continuity of organismal development initiated at fertilization is asserted as clear and reasonable grounds for moral standing. Within this frame of analysis, it is proposed that through a technique of Altered Nuclear Transfer, non-organismal entities might be created from which embryonic stem cells could be morally procured. Criteria for patenting of such non-organismal entities are considered. An earlier version of this paper was presented at an international conference, “The Ethics of Intellectual Property Rights and Patents,” held in Warsaw, Poland on 23–24 April, 2004.     

Why-questions, determinism and circular reasoning

In this article I shall aim at showing that there exists beneath the surface of many why-questions about human behaviour a nest of deterministic assumptions which can preclude their ever being truly answered. A symptom of the presence of these underlying assumptions can be observed in an explanation-seeking dialogue in which the questioner persistently tries to discover why a certain human behaviour occurred. He repeats his why-question until he gets the type of answer he wants, but in the process he effectively reasons in a circle. If the repeated questioning with its implied circular reasoning becomes chronic, then the questioner will beg the question with regards to the answer he desires and consequently run the risk of missing the truth.     

ON THE EVOLUTION OF HUMAN FREEDOM

Abstract. The age–old dilemma of free will and determinism is attacked by proving that both sides are flawed with contingencies, that the notion of eternal law is a theologically tainted projection rather than a reality of the real world that is understood to be evolutionary. Determinism is dissolved into conditionalism. This excludes materialistic scientific explanation of the deterministic style. As it brings forth freedom, evolutionary reality transcends essentially the explanatory possibilities of statistically structured natural laws. The dilemma of determinism and free will based on a logic of contradiction is replaced by an ontology of polarity.     

The Biology of Morality

Abstract. The morality of human beings, defined here as our ability to determine whether our actions are right or wrong, depends not just on following rules but also on understanding the impact of our actions on another person. How we understand the impact of our actions on another person depends on our state of consciousness, which is mediated by our brain and nervous system. We describe how we understand our morality to flow naturally from the biological state we are living in and how we see our biology and our morality as mutually interactive. A change in one changes the other. Another way of saying this is that changing either our morality or our biology changes both—changes who we are and what we do.     

The Machinations of Luck

Luck is at issue when it is a matter of pure chance that a result of significant positive of negative value ensues for someone. Luck differs from fate, which pivots on an individual's condition, and from fortune, which pivots on an individual's talent and effort. It is by luck that you are rich when you win the lottery, by fortune if your wealth comes from talent and hard work, and by fate if you inherit those millions. On this basis luck lies beyond anyone's rational control. With risk (R) as the probability of failure in a chancy situation and the stake (S) as the difference between a favorable and an unfavorable outcome, luck (L) can be measured as the product of these quantities: L = R × S. The condition of humankind in an uncertain world being as it is, luck cannot be eliminated as a key factor of our existence, be it in cognitive, practical, or ethical regards.     

The Ontological Roots of Human Science: the Message of Evolution—The Physics of Freedom (Choice)

The original proposal of H. H. Pattee (1971) Pattee, H. H. 1971. “Can life explain quantum mechanics?”. In Quantum theory and beyond, Edited by: Bastin, T. 307–319. Cambridge: Cambridge University Press.  [Google Scholar] of basing quantum theoretical measurement theory on the theory of the origin of life, and its far reaching consequences, is discussed in the light of a recently emerging biological paradigm of internal measurement. It is established that the “measurement problem” of quantum physics can, in principle, be traced back to the internal material constraints of the biological organisms, where choice is a fundamental attribute of the self-measurement of matter. In this light, which is shown to be a consequence of Pattee's original suggestion, it is proposed that biological evolution is a gradual liberation from the inert unity of “subject” and “object” of inanimate matter (as “natural law” and “initial conditions”), to a split biological existence of them and, as a consequence, the “message of evolution” is freedom, rather than complexity in itself. Some classical philosophical systems are brought into context to show that the epistemologies of several strictly philosophical systems of the social sciences are well acquainted with the problem and their solutions support our conclusions.     

Highly fluorescent silver nanofluids with ferroelectric molecules

Highly fluorescent silver nanoparticles (Ag-NPs), soluble in a ferroelectric host of polymer molecules such as poly(vinylidene fluoride) (PVF₂), have been created in the form of nanofluids. The content of Ag-NPs (flocculates) is varied in steps 0.1–0.2 wt% up to a value of 5.0 wt% in tailoring a broad green emission band over 520–620 nm out of a hybrid percolation Ag–PVF₂ composite. A maximum intensity arises in this band at as small a percolation threshold as ～0.1 wt% Ag-NPs. It contains three distinct bands of peak values 541, 565, and 582 nm in an Ag-NPs tunable response of the localized surface plasmons. The emission-dependent anti-Stokes excitation spectrum contains a similar group of three bands 348, 401, and 421 nm. For Ag-contents above 0.1 wt%, interdependent intensities in the emission and excitation bands drop rapidly by as much as five times, conferring a metal–polymer percolation network. The results open wide applications for biological labels and light emitters using such nanofluids.     

肿瘤干细胞分离方法研究现状

肿瘤干细胞理论能够解释肿瘤的发生、发展和转移等生物学行为,使人们对恶性肿瘤有一个全新的认识,为临床治疗展现全新视角,使肿瘤靶向治疗找到了新靶点,改变目前药物针对全部癌细胞的治疗策略。本文就肿瘤干细胞分离方法做一简要综述。