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Benoît Beck Phil Iversen Andreas Sashegyi 《Journal of Multi-Criteria Decision Analysis》2014,21(3-4):139-151
Taking decisions during the development of a new drug requires combining many and varying pieces of information. The interconnections between these different pieces of information are often only partially known and in some cases merely conjectured. Despite this uncertainty, decisions must be taken – often with regard to the balance of risk and benefit – in order to make progress. A clear, consistent and efficient methodology for describing the structure of a project and the comprehensive state of knowledge at any point in time is required in order to add transparency to the decision process. A viable methodology must allow for a natural characterization of the uncertainty inherent in the drug development process and a relatively easy implementation. We present a possible solution that satisfies these requirements. The foundation of the proposed approach is based on a beta‐binomial update mechanism well known in Bayesian statistics. This work provides a consistent framework for solving hierarchical multicriteria decision problems. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
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《Quarterly journal of experimental psychology (2006)》2013,66(3):505-526
Recently, there has been considerable debate about whether readers can identify multiple words in parallel or whether they are limited to a serial mode of word identification, processing one word at a time (see, e.g., Reichle, Liversedge, Pollatsek, & Rayner, 2009). Similar questions can be applied to bimorphemic compound words: Do readers identify all the constituents of a compound word in parallel, and does it matter which of the morphemes is identified first? We asked subjects to read compound words embedded in sentences while monitoring their eye movements. Using the boundary paradigm (Rayner, 1975), we manipulated the preview that subjects received of the compound word before they fixated it. In particular, the morpheme order of the preview was either normal (cowboy) or reversed (boycow). Additionally, we manipulated the preview availability for each of the morphemes separately. Preview was thus available for the first morpheme only (cowtxg), for the second morpheme only (enzboy), or for neither of the morphemes (enztxg). We report three major findings: First, there was an effect of morpheme order on gaze durations measured on the compound word, indicating that, as expected, readers obtained a greater preview benefit when the preview presented the morphemes in the correct order than when their order was reversed. Second, gaze durations on the compound word were influenced not only by preview availability for the first, but also by that for the second morpheme. Finally, and most importantly, the results show that readers are able to extract some morpheme information even from a reverse order preview. In summary, readers obtain preview benefit from both constituents of a short compound word, even when the preview does not reflect the correct morpheme order. 相似文献
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Aleksandra Luszczynska Alicja B. Durawa Marta Dudzinska Marta Kwiatkowska Brygida Knysz Nina Knoll 《Psychology & health》2013,28(10):1227-1243
Individuals confronted with a life-threatening illness often report posttraumatic growth (PTG) or finding benefits in disease. These positive evaluations of personal strength, perceptions of improved personal relations and new possibilities may represent a defensive response (cf Janus-face model). Three studies investigated the effects of mortality reminders on reports of PTG or benefit findings among people living with life-threatening illness or their caregivers. 80 people living with HIV (Study 1), 164 breast cancer survivors (Study 2) and 50 family caregivers for a patient with Huntington Disease (Study 3) were randomly assigned to the experimental (mortality reminders) or control conditions. Across three studies, those exposed to mortality reminders reported lower PTG or benefit finding, compared to the controls. These effects were moderated by time elapsed since diagnosis: mortality reminders led to lower PTG/benefit finding among those who received the diagnosis more recently. The results provide an insight into the defensive character of PTG/finding benefits in illness and changes in the function of these beliefs over time elapsing since diagnosis. 相似文献
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Liza-Marie Johnson Christopher L. Church Monika Metzger Justin N. Baker 《The American journal of bioethics : AJOB》2015,15(5):3-17
There is little information about the content of ethics consultations (EC) in pediatrics. We sought to describe the reasons for consultation and ethical principles addressed during EC in pediatrics through retrospective review and directed content analysis of EC records (2000–2011) at St. Jude Children's Research Hospital. Patient-based EC were highly complex and often involved evaluation of parental decision making, particularly consideration of the risks and benefits of a proposed medical intervention, and the physician's fiduciary responsibility to the patient. Nonpatient consultations provided guidance in the development of institutional policies that would broadly affect patients and families. This is one of the few existing reviews of the content of pediatric EC and indicates that the distribution of ethical issues and reasons for moral distress are different than with adults. Pediatric EC often facilitates complex decision making among multiple stakeholders, and further prospective research is needed on the role of ethics consultation in pediatrics. 相似文献
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Ronald J. Burke 《Anxiety, stress, and coping》2013,26(1):3-5
Abstract For many decades, the stress process was described primarily in terms of negative emotions. However, robust evidence that positive emotions co-occurred with negative emotions during intensely stressful situations suggested the need to consider the possible roles of positive emotions in the stress process. About 10 years ago, these possibilities were incorporated into a revision of stress and coping theory (Folkman, 1997). This article summarizes the research reported during the intervening 10 years that pertains to the revised model. Evidence has accumulated regarding the co-occurrence of positive and negative emotions during stressful periods; the restorative function of positive emotions with respect to physiological, psychological, and social coping resources; and the kinds of coping processes that generate positive emotions including benefit finding and reminding, adaptive goal processes, reordering priorities, and infusing ordinary events with positive meaning. Overall, the evidence supports the propositions set forth in the revised model. Contrary to earlier tendencies to dismiss positive emotions, the evidence indicates they have important functions in the stress process and are related to coping processes that are distinct from those that regulate distress. Including positive emotions in future studies will help address an imbalance between research and clinical practice due to decades of nearly exclusive concern with the negative emotions. 相似文献
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Daniel L. Segal Heather C. Tucker Frederick L. Coolidge 《Journal of aggression, maltreatment & trauma》2013,22(4):367-381
This study investigated the effects of expressing through writing either positive feelings, negative feelings, or both about an upsetting event in order to assess which mode of expression facilitated greater emotional and cognitive processing. Undergraduate student participants with self-reported unresolved upsetting experiences were randomly assigned to one of three writing groups. After completing three writing sessions, they were evaluated at baseline, postexperimentally, and at 1-month follow-up. All groups experienced positive benefits; however, participants in the positive writing group showed greater adaptive cognitive changes than the other groups. Thus it appears that the written expression of positive feelings is as therapeutic as the written expression of negative emotions, which may prompt increased cognitive reorganization or benefit finding among a nonclinical sample. 相似文献
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高危型人类乳头瘤病毒(HR—HPV)感染是宫颈癌发生的必要条件,本文就是否将HR—HPV纳入宫颈癌筛查进行探讨。通过对我院行宫颈癌筛查的2505例患者资料分析,结果显示对于经济条件良好或有宫颈癌高危因素的女性,细胞学检查(TCT)联合HR—HPV检测做为宫颈癌的初筛,其临床效益大于成本收益。 相似文献
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Rule finding is an important aspect of human reasoning and flexibility. Previous studies associated rule finding failure with past experience with the test stimuli and stable personality traits. We additionally show that rule finding performance is severely impaired by a mindset associated with applying an instructed rule. The mindset was established in Phase 1 (manipulation) of the experiment, before rule finding ability was assessed in Phase 2 (testing). The impairment in rule finding was observed even when Phase 1 involved executing a single trial (Experiment 2), and when entirely different stimuli and rules were used in the two phases of the experiment (Experiments 3–6). Experiments 4–6 show that applying an instructed rule in Phase 1 impaired subsequent (Phase 2) feedback evaluation, rule generation, and attention switching between rules, which are the three component processes involved in rule finding according to COVIS (Ashby, Alfonso-Reese, Turken, & Waldron, 1998). 相似文献