糖尿病教育在2型糖尿病防控工作中的重要性

近年来,由于糖尿病的高患病率、高致残率和高死亡率带来沉重的社会和经济负担。预防糖尿病发生、改善糖尿病患者现况等均提示推广普及糖尿病教育具有重要意义。通过糖尿病教育可以全面改善患者临床控制指标、知识水平、自我管理水平和自我效能水平,且从卫生经济学角度分析显示其投入相对较小的成本即可达到良好的效果和效用,因而在糖尿病防控体...     

OSAHS在2型糖尿病发病中的作用与对策

阻塞性睡眠呼吸暂停综合征（obstructive sleep apnea hypopnea syndrome,OSAHS）是一种常见的睡眠呼吸紊乱性疾病,以睡眠时反复发作的上气道部分或完全阻塞为特征。近年发现OSAHS与2型糖尿病之间有着明显的相关性,二者均为心血管疾病的高危因素,合并存在能够严重影响生命质量与预期寿命...     

关系研究的新取向：社会网络分析

社会网络分析（Social Network Analysis, SNA）是用社会实体之间的关系来描述、解释和预测社会现象的一种研究取向。SNA提供了深入探究社会环境特征及其对个体心理发展影响的一种方法。本文基于SNA的发展历程,依次介绍了中心性分析、小团体分析、位置分析、QAP以及统计模型法。SNA在社会学研究中得到了较多应用,近年来在心理学研究中开始受到重视。     

审视马克思的工作室:马恩全集中的《资本论》及前期准备工作

本文以《资本论》及其手稿为例介绍了MEGA2即历史上第二次启动的马恩全集历史考证版的编纂工作和特征。作者指出,马克思和恩格斯之间的差异,以及马克思研究工作方式的开放性,是MEGA2这一历史考证版力图展现的两个重点,这一全集版本将开启通向马克思与恩格斯及其浩瀚著作的新入口。文章主体分三个部分,第一部分以《资本论》及其手稿的写作过程为例考察了马克思的工作方式,即他在研究写作中体现出的作为修改者和收集者的特征;第二部分以MEGA2中《资本论》及其手稿的编纂为例,介绍了这一历史考证版是如何展现马克思的工作方式,以及作者马克思和编者恩格斯之间差异的;第三部分介绍了目前网络空间里MEGA2的发布情况。     

Enhanced learning by posttrial injection of H1-but not H2-histaminergic antagonists into the nucleus basalis magnocellularis region

The aim of this study was to examine the effects of histaminergic antagonists on memory upon injection into the region of the nucleus basalis magnocellularis (NBM). In experiment 1, rats with chronically implanted cannulae were trained on the uphill avoidance task, which involves a punishment of a high-probability turning response on a tilted platform (negative geotaxis). Immediately after the training trial, that is, after a tail shock was administered upon performing the response, rats received one microinjection (0.5 microliter) of H1-receptor blocker chlorpheniramine (dose range 0.1 to 20 microgram) or the H2-receptor blocker ranitidine (same dose range) or saline into the NBM region. When tested 24 h later, rats treated with chlorpheniramine (20 micrograms) had significantly longer uphill latencies than vehicle controls and ranitidine-treated animals, indicative of superior learning of the avoidance response. In experiment 2, a test for possible proactive effects of posttrial chlorpheniramine on performance during the retention trial was performed. Animals were injected with either 20 micrograms chlorpheniramine or saline immediately after the training trial of the uphill task. One chlorpheniramine control group was treated with a delay of 5 h. Additional groups which received chlorpheniramine or vehicle after the training trial but no trail shock were included. When tested 24 h later, rats injected with 20 micrograms chlorpheniramine again exhibited significantly longer uphill latencies than did vehicle-injected rats. Retention latencies for the rats of the chlorpheniramine 5-h delayed group did not differ from those of the vehicle-injected rats, ruling out proactive effects of chlorpheniramine on performance. In summary, the histaminergic H1-blocker chlorpheniramine can enhance mnemonic functioning in addition to its reinforcing effects upon NBM injection as reported previously.     

厌恶与恐惧情绪习得的性别差异研究:一项ERP研究

采用事件相关电位技术（ERPs）,用条件性习得范式探讨厌恶与恐惧情绪习得的性别差异。行为结果表明,在成功习得厌恶、恐惧和中性情绪之后,男女性在唤醒度维度上,性别差异显著;脑电结果表明,在早期N1和P2成分,厌恶情绪与恐惧情绪的习得无显著性别差异;但男女不同性别在N2成分上差异显著,主要表现为女性在厌恶、恐惧、中性这三类CS的N2成分均差异显著,但男性仅厌恶与中性情绪的CS差异显著。结果表明在负性情绪的习得中,女性比男性更敏感。     

The inclosure scheme and the solution to the paradoxes of self-reference

Proponents of the explanatory gap claim that consciousness is a mystery. No one has ever given an account of how a physical thing could be identical to a phenomenal one. We fully understand the identity between water and H₂O but the identity between pain and the firing of C-fibers is inconceivable. Mark Johnston [Journal of philosophy (1997), 564–583] suggests that if water is constituted by H₂O, not identical to it, then the explanatory gap becomes a pseudo-problem. This is because all “manifest kinds”—those identified in experience—are on a par in not being identical to their physical bases, so that the special problem of the inconceivability of ‘pain = the firing of C-fibers’ vanishes. Moreover, the substitute relation, constitution, raises no explanatory difficulties: pain can be constituted by its physical base, as can water. The thesis of this paper is that the EG does not disappear when we substitute constitution for identity. I examine four arguments for the EG, and show that none of them is undermined by the move from constitution to identity.     

糖尿病高血压和糖尿病肾病患者血清MMP-2及TIMP-1的表达及意义

为了探讨MMP-2、TIMP-1在DMEH和DN发病中的意义,随机收集T2DM患者146例,其中SDM 57例,DMEH 38例,DN 51例,健康对照38例。用ELISA法测定MMP-2、TIMP-1的含量。结果显示,DM患者尤其是DMEH和DN患者血清MMP-2明显低于健康对照组,P均〈0.01,且随病情发展呈逐渐降低趋势。而血清TIMP-1随病情的发展则呈现明显的上升趋势,SDM、DMEH组和DN组与健康对照组比较,分别为P〈0.05,P〈0.01和P〈0.01。因此,MMP-2和TIMP-1可能参与了DMEH和DN的发生发展过程,定期检测DM患者血清MMP-2和TIMP-1的含量变化有助于DM并发症的早期诊断和疗效观察。