Predictive Genetic Testing for Hereditary Breast and Ovarian Cancer: Psychological Distress and Illness Representations 1 Year Following Disclosure

This prospective study evaluates emotional functioning and illness representations in 68 unaffected women (34 carriers/34 noncarriers) 1 year after predictive testing for BRCA1/2 mutations when offered within a multidisciplinary approach. Carriers had higher subjective risk perception of breast cancer than noncarriers. Carriers who did not have prophylactic oophorectomy had the highest risk perception of ovarian cancer. No differences were found between carriers and noncarriers regarding perceived seriousness and perceived control of breast and ovarian cancer. Mean levels of distress were within normal ranges. Only few women showed an overall pattern of clinically elevated distress. Cancer-specific distress and state-anxiety significantly decreased in noncarriers from pre- to posttest while general distress remained about the same. There were no significant changes in distress in the group of carriers except for ovarian cancer distress which significantly decreased from pre- to posttest. Our study did not reveal adverse effects of predictive testing when offered in the context of a multidisciplinary approach.     

Evaluating the Impact of Genetic Counseling and Testing with Signal Detection Methods

One measure of the impact of genetic counseling and testing (GCT) is the extent to which it fosters behavioral change that is consistent with mutation status. We describe and illustrate how two different signal detection methods, receiver operating characteristic (ROC) analysis and recursive partitioning, can be used in this context to evaluate the impact of GCT. We analyzed real screening behavior data obtained in the 12 months following GCT for Hereditary Nonpolyposis Colon Cancer (HNPCC) using these two different signal detection approaches. Each approach demonstrated that GCT had an impact on behavioral outcomes, and was effective in fostering behavioral outcomes appropriate to mutation status. The ROC approach demonstrated that GCT was effective because mutation positive and mutation negative individuals could be distinguished on the basis of the number of recommended screening behaviors. The recursive partitioning approach demonstrated that GCT was effective because there were generally high rates of adherence to screening guidelines among subjects. The recursive partitioning technique also identified four subgroups of subjects, each with distinct characteristics, for which tailored interventions could be developed to increase rates of adherence to screening guidelines. Signal detection methods are easily implemented and are useful techniques for evaluating the impact of GCT.     

Using response times to detect aberrant responses in computerized adaptive testing

A lognormal model for response times is used to check response times for aberrances in examinee behavior on computerized adaptive tests. Both classical procedures and Bayesian posterior predictive checks are presented. For a fixed examinee, responses and response times are independent; checks based on response times offer thus information independent of the results of checks on response patterns. Empirical examples of the use of classical and Bayesian checks for detecting two different types of aberrances in response times are presented. The detection rates for the Bayesian checks outperformed those for the classical checks, but at the cost of higher false-alarm rates. A guideline for the choice between the two types of checks is offered.This study received funding from the Law School Admission Council (LSAC). The opinions and conclusions contained in this paper are those of the authors and do not necessarily reflect the policy and position of LSAC. The authors are most indebted to Wim M. M. Tielen for his computational assistance and to the US Defense Manpower Data Center for the permission to use the ASVAB data set in the empirical examples.     

The Ethics of Type 1 Diabetes Prediction and Prevention Research

There are approximately one million cases oftype 1 diabetes in the US, and the incidenceis increasing worldwide. Given that two-thirdsof cases present in childhood, it is criticalthat prediction and prevention research involvechildren. In this article, I examine whethercurrent research methodologies conform to theethical guidelines enumerated by the NationalCommission for the Protection of Human Subjectsof Biomedical and Behavioral Research, andadopted into the federal regulations thatprotect research subjects. I then offer twopolicy recommendations to help researchersdesign studies that conform to these ethicalrequirements.     

Integrity and Honesty Testing: What Do We Know? How Do We Use It?

This selective review of integrity and honesty testing addresses two primary questions: ‘What do we know about honesty testing?’ and ‘How do we use what we know?’ Up-to-date information about test reliability, validity, and construct definition from recent reviews of the research literature in the USA is presented and interpreted. Relationships to other selection devices and personality measures are discussed, as well as how integrity tests fit into a multiple assessment selection system.     

Study for now,but judge for later: Delayed judgments of learning promote long‐term retention

Larsson Sundqvist, M., Todorov, I., Kubik, V. & Jönsson, F.U. (2012) Study for now, but judge for later: Delayed judgments of learning promote long‐term retention. Scandinavian Journal of Psychology 53, 450–454. Delayed judgments of learning (JOL) are assumed to be based on covert retrieval attempts. A common finding is that testing memory during learning improves later retention (i.e., the testing effect), and even more so than an equivalent amount of study, but only after a longer retention interval. To test the assertion that also delayed JOLs improve memory, the participants either studied Swahili‐Swedish word pairs four times, or they both studied (two times) and performed delayed JOLs (two times) alternately. Final cued recall test were given after either five minutes or one week. Results showed a reliable learning‐group by retention‐interval interaction, with less forgetting in the group that alternated between studying and making JOLs. The results are discussed in relation to the self‐fulfilling prophecy account of Spellman and Bjork (1992) , and in terms of study advice, the results further underscore the importance of delaying JOLs when studying and evaluating one’s ongoing learning.     

Faking on self-report emotional intelligence and personality tests: Effects of faking opportunity, cognitive ability, and job type

We assessed the combined effects of cognitive ability, opportunity to fake, and trait job-relevance on faking self-report emotional intelligence and personality tests by having 150 undergraduates complete such tests honestly and then so as to appear ideal for one of three jobs: nurse practitioner, marketing manager, and computer programmer. Faking, as expected, was greater (a) in higher-g participants, (b) in those scoring lower under honest conditions (with greater opportunity to fake), and (c) on job-relevant traits. Predicted interactions accounted for additional unique variance in faking. Combining all three factors yielded a “perfect storm” standardized difference of around 2, more than double the overall .83 estimate. Implications for the study of faking are discussed.     

新世纪20年国内假设检验及其关联问题的方法学研究

新世纪20年来国内假设检验方法学研究内容可分为如下几类: 零假设显著性检验的不足、p值的使用问题、心理学研究的可重复性问题、效应量、检验力、等效性检验、其他与假设检验关联的研究。零假设显著性检验已经发展成一套组合流程: 为了保证检验力和节省成本, 实验研究需要做先验检验力分析预估样本容量, 但问卷超过160人在传统统计中就没有必要这样做。当拒绝零假设时, 应当结合效应量做出结论。当不拒绝零假设时, 需要报告后验检验力; 如果效应量中或大而检验力不够高, 则可增加被试再行分析, 但这一过程应主动披露, 报告最后的实际p值并对可能犯的第一类错误率做出评估。     

基于项目区分度的双目标CD-CAT选题策略

针对双目标CD-CAT,将六种项目区分度（鉴别力D、一般区分度GDI、优势比OR、2PL的区分度a、属性区分度ADI、认知诊断区分度CDI）分别与IPA方法结合,得到新的选题策略。模拟研究比较了它们的表现,还考察了区分度分层在控制项目曝光的表现。结果发现：新方法都能明显提高知识状态的判准率和能力估计精度;分层选题均能很好地提高题库利用率。总体上,OR加权能显著提高测量精度;OR分层选题在保证测量精度条件下显著提高项目曝光均匀性。     

计算机化分类测验终止规则的类别、特点及应用

计算机化分类测验(Computerized Classification Testing, CCT)能够高效地对被试进行分类, 已广泛应用于合格性测验及临床心理学中。作为CCT的重要组成部分, 终止规则决定测验何时停止以及将被试最终划分到何种类别, 因此直接影响测验效率及分类准确率。已有的三大类终止规则(似然比规则、贝叶斯决策理论规则及置信区间规则)的核心思想分别为构造假设检验、设计损失函数和比较置信区间相对位置。同时, 在不同测验情境下, CCT的终止规则发展出不同的具体形式。未来研究可以继续开发贝叶斯规则、考虑多维多类别情境以及结合作答时间和机器学习算法。针对测验实际需求, 三类终止规则在合格性测验上均有应用潜力, 而临床问卷则倾向应用贝叶斯规则。