基因检测与治疗中若干问题的伦理学思考

随着基因组学的发展,临床医学中出现了基因检测与基因治疗的新方法,伴随着基因技术的临床应用出现了一些伦理、法律和社会新问题,迫使人们从理论和观念层次加以考察并探讨解决问题的可能性途径,对基因检测和基因治疗中出现或可能出现的伦理学问题进行了初步探讨,结合国际人类基因组计划的有关规范,探索了解决问题的可能性途径。     

The Influence of Phonological Context on the Sound Errors of a Speaker with Wernicke's Aphasia

A corpus of phonological errors produced in narrative speech by a Wernicke's aphasic speaker (R.W.B.) was tested for context effects using two new methods for establishing chance baselines. A reliable anticipatory effect was found using the second method, which estimated chance from the distance between phoneme repeats in the speech sample containing the errors. Relative to this baseline, error-source distances were shorter than expected for anticipations, but not perseverations. R.W.B.'s anticipation/perseveration ratio measured intermediate between a nonaphasic error corpus and that of a more severe aphasic speaker (both reported in Schwartz et al., 1994), supporting the view that the anticipatory bias correlates to severity. Finally, R.W.B's anticipations favored word-initial segments, although errors and sources did not consistently share word or syllable position.     

小学儿童假设检验思维策略的发展

采用自创的“固定样例”程序,利用自行设计的两种不同任务的图形推理材料,研究了小学儿童假设检验策略的发展。550名不同年级的被试参加了本研究：结果发现,在该研究条件下：(1)答案存在多种可能性的任务Ⅰ明显难于答案确定的任务Ⅱ;(2)小学儿童假设检验能力随年级提高而增长,但增长的速度因任务不同而不同;(3)随着年级的提高,小学儿童使用的不成功策略逐步下降,成功策略显著上升,但这也受任务不同的影响;(4)固定样例程序较好地克服了变化样例程序所带来的假设检验研究的缺陷。     

A Systemic Approach to Fetal Loss Following Genetic Testing

Advances in genetic technology challenge couples to make complex life and death decisions about their fetus that have far-reaching practical and emotional consequences. When genetic defects lead to fetal loss, whether by miscarriage, elective interruption, or still birth, it can be a devastating experience with ripple effects on couple and family development. This paper presents a systemic approach to coping and adaptation to fetal loss in the wake of genetic testing. Clinical vignettes illustrate common experiences and present interventions designed to help the individual grieving partners as well as the marriage. thereby strengthening the family fabric at a vulnerable transitional stage.     

变长CD-CAT中的曝光控制与终止规则

本研究借鉴传统计算机化自适应测验的思想, 并结合认知诊断的特点, 在认知诊断框架下提出了4种变长CD-CAT的终止规则, 分别是属性标准误法(SEA)、邻近后验概率之差法(DAPP)、二等分法(HA)以及混合法(HM)。在未控制曝光和采用不同曝光控制条件下, 与HSU法及KL法进行了比较。研究结果表明：(1) 终止条件越严格, 平均测验长度越长, 按测验长度最大值终止的测验百分比越大, 模式判准率越高。(2) 当未加入曝光控制时, 4种新的终止规则均有较好表现, 与HSU法十分接近。随着最大后验概率预设值的增加或e的减小, 模式判准率呈上升趋势, 平均测验长度逐渐增加, 但在题库使用率方面均较差。(3) 当加入项目曝光控制时, 6种变长终止规则下的题库使用率有了极大的提升, 仍能保持较高的模式判准率, 并且不同的曝光控制方法对终止规则的影响是不同的。其中, 相对标准终止规则极易受到曝光控制方法的影响。(4) 综合来看, SEA、HM以及HA法在各项指标上的表现与HSU法基本一致, 其次为KL法和DAPP法。     

Measuring misinformation in repeat trial pick 1 of 2 tests

An extension is described to a product testing model to account for misinformation among subjects. A misinformed subject is one who associates the taste of product A with product B and vice-versa; thus, the subject would tend to perform incorrectly on pick 1 of 2 tests. A likelihood ratio test for the presence of misinformation is described. The model is applied to a data set, and misinformation is found to exist. Biases due to model misspecificationand other implications for product testing are discussed.The first author is currently on leave from Carnegie Mellon University.     

差数显著性t检验与元分析的对比研究

利用计算机构造被试总体、模拟实验研究程序进行抽样研究,探讨显著性ｔ检验方法与元分析方法在检验实验结果数据方面的差异。在模拟实验过程中,ｔ验受到显著性水平、样本容量和总体效果大小的影响,因此最终影响了统计推断的可靠性,建议：在进行显著性检验过程中,应对统计检验能力进行估计;元分析方法以样本为元素对总体进行推断,因此具有很高的准确性和可靠性,它将很有可能成为今后心理学研究的重要统计工具。     

Behavioral community psychology: training a community board to problem solve

This study demonstrated the effect of training nine lower socio-economic adults participating as policy board members in a federally funded rural community project to make behaviorally defined statements to increase problem-solving behaviors in board meetings. A multiple-baseline design across subjects and skills was used to analyze the behavioral categories of: (1) stating the problem; (2) finding solutions to the problem, and (3) implementing the action to the solution. Problem-solving responses during board meetings increased for subjects following training and remained higher than baseline during follow-up.     

Training public-speaking behavior: an experimental analysis and social validation

The effect of an instructional package on public-speaking behaviors was analyzed in two experiments. The instructional package was designed to teach public-speaking trainees to look at the audience, make gestures, and perform a number of speaking behaviors. The results of Experiment I, with a university student serving as the trainee, showed that the percentage of each category of public-speaking target behavior increased only after the instructional package was introduced for that category. The results of Experiment 2, with three low-income paraprofessional staff members of a neighborhood service center serving as trainees, showed that the percentage of target behaviors increased after the instructional package was introduced for the respective trainee. Audience ratings of public-speaking performance were correlated with direct observations of target responses. All trainees showed marked improvements in audience ratings from pretraining to posttraining. This study demonstrated an effective procedure for training public-speaking behaviors.