Personal Dispositions and Shift‐Work Tolerance: A Longitudinal Study of Municipality Shift Workers

The aim of this study was to investigate how dispositional resistance to change and neuroticism could predict shift‐work tolerance (SWT) over a period of 6 months. Electronic questionnaires were completed by 74 shift workers employed in a municipality in Norway in January 2013 (1st wave of data collection) and in June 2013 (2nd wave of data collection). The findings suggest that individual differences, especially neuroticism, can predict SWT over a period of 6 months.     

The effect of question type on resistance to misinformation about present and absent details

The typical misinformation effect shows that accuracy is lower for details about which people received misleading compared to non-misleading (control) information. In two experiments, we examined the misinformation effect for non-witnessed details (i.e., absent). Three question types introduced control, misleading, and absent details (closed, closed-detailed, and open questions) about a mock burglary video. On this misinformation test, participants' reports of absent details were less accurate than control details only when they were introduced using open questions. Misinformation effects in a subsequent recognition test were present for misleading details in both experiments, but for absent details only in Experiment 2. Experiment 2 also revealed that participants who avoided answering open questions containing misleading and absent details had more accurate memories for these details on the subsequent recognition test than participants who answered these questions. In both experiments, confidence was lowest for absent details. Implications for theory and practice are discussed.     

Response–reinforcer dependency and resistance to change

The effects of the response–reinforcer dependency on resistance to change were studied in three experiments with rats. In Experiment 1, lever pressing produced reinforcers at similar rates after variable interreinforcer intervals in each component of a two‐component multiple schedule. Across conditions, in the fixed component, all reinforcers were response‐dependent; in the alternative component, the percentage of response‐dependent reinforcers was 100, 50 (i.e., 50% response‐dependent and 50% response‐independent) or 10% (i.e., 10% response‐dependent and 90% response‐independent). Resistance to extinction was greater in the alternative than in the fixed component when the dependency in the former was 10%, but was similar between components when this dependency was 100 or 50%. In Experiment 2, a three‐component multiple schedule was used. The dependency was 100% in one component and 10% in the other two. The 10% components differed on how reinforcers were programmed. In one component, as in Experiment 1, a reinforcer had to be collected before the scheduling of other response‐dependent or independent reinforcers. In the other component, response‐dependent and ‐independent reinforcers were programmed by superimposing a variable‐time schedule on an independent variable‐interval schedule. Regardless of the procedure used to program the dependency, resistance to extinction was greater in the 10% components than in the 100% component. These results were replicated in Experiment 3 in which, instead of extinction, VT schedules replaced the baseline schedules in each multiple‐schedule component during the test. We argue that the relative change in dependency from Baseline to Test, which is greater when baseline dependencies are high rather than low, could account for the differential resistance to change in the present experiments. The inconsistencies in results across the present and previous experiments suggest that the effects of dependency on resistance to change are not well understood. Additional systematic analyses are important to further understand the effects of the response–reinforcer relation on resistance to change and to the development of a more comprehensive theory of behavioral persistence.     

Preference,resistance to change,and the cumulative decision model

According to behavioral momentum theory (Nevin & Grace, 2000a), preference in concurrent chains and resistance to change in multiple schedules are independent measures of a common construct representing reinforcement history. Here I review the original studies on preference and resistance to change in which reinforcement variables were manipulated parametrically, conducted by Nevin, Grace and colleagues between 1997 and 2002, as well as more recent research. The cumulative decision model proposed by Grace and colleagues for concurrent chains is shown to provide a good account of both preference and resistance to change, and is able to predict the increased sensitivity to reinforcer rate and magnitude observed with constant‐duration components. Residuals from fits of the cumulative decision model to preference and resistance to change data were positively correlated, supporting the prediction of behavioral momentum theory. Although some questions remain, the learning process assumed by the cumulative decision model, in which outcomes are compared against a criterion that represents the average outcome value in the current context, may provide a plausible model for the acquisition of differential resistance to change.     

Prevalence of Types of Perpetration: Gender and Patterns of Intimate Partner Violence Within a Prison Sample in Singapore

It has been reported in Western research on intimate partner violence (IPV) that there are similar rates between males and females (Filbert, 2010). The objective of this study was to compare male and female prisoners from Singapore on rates of IPV as well as the Johnson (2006) types of IPV. Women (n = 75) self-reported higher rates of physical IPV perpetration in the past year (64.0%) than (n = 75) did men (46.1%). Women reported similar rates of IPV for themselves and their partners in the past year (64.0%), while men reported slightly more physical IPV for themselves (46.1%) than they did for their female partners (41.3%). In line with Johnson (2006), rates of intimate terrorism were calculated between 5% and 7% for themselves and their partners, with little variation due to gender. Violent resistance (VR) was calculated at between 2.1% and 7%, with more female than male VR reported for women. Much higher rates of situational couple violence was calculated for both males and females, ranging from 53.3% to 66.7% in the past year, while mutual violent control was significantly lower, ranging from between 14.8% to 20.0%, with data being discussed in relation to patriarchal and family violence perspectives. We concluded that the rates of IPV between males and females were very similar as were the types of IPV. Further research with other cultures should be encouraged for comparison with Western samples.     

克服肿瘤干细胞耐药性的策略和思路

肿瘤干细胞（cancersterncells,CSCs）是肿瘤细胞的祖细胞。已有的研究表明,肿瘤干细胞对多种化疗药物具有耐药性,是导致肿瘤治疗后复发的根源。研究针对肿瘤干细胞的治疗方法,克服肿瘤干细胞耐药性,将给肿瘤治疗模式带来全新的改变,有望彻底改善肿瘤患者的预后。     

冠脉介入治疗时期氯吡格雷抵抗的认识与思考——抓住本质，全面获益

急性冠脉综合征已步入药物洗脱支架进行血运重建的时期,双联抗血小板治疗是接受PCI治疗的常规手段。临床发现部分患者不能从氯吡格雷治疗中获益,存在氯吡格雷抵抗的现象。笔者就氯吡格雷抵抗的发生机制、临床意义及治疗对策进行描述,反映相关研究的趋势和方向,为未来更优化抗血小板治疗提出一种策略。     

Within-subject testing of the signaled-reinforcement effect on operant responding as measured by response rate and resistance to change

Response rates under random-interval schedules are lower when a brief (500 ms) signal accompanies reinforcement than when there is no signal. The present study examined this signaled-reinforcement effect and its relation to resistance to change. In Experiment 1, rats responded on a multiple random-interval 60-s random-interval 60-s schedule, with signaled reinforcement in only one component. Response resistance to alternative reinforcement, prefeeding, and extinction was compared between these components. Lower response rates, and greater resistance to change, occurred in the component with the reinforcement signal. In Experiment 2, response rates and resistance to change were compared after training on a multiple random-interval 60-s random-interval 60-s schedule in which reinforcer delivery was unsignaled in one component and a response-produced uncorrelated stimulus was presented in the other component. Higher response rates and greater resistance to change occurred with the uncorrelated stimulus. These results highlight the significance of considering the effects of an uncorrelated signal when used as a control condition, and challenge accounts of resistance to change that depend solely on reinforcer rate.     

Employee Cynicism and Resistance to Organizational Change

We offer a reconceptualization of employee cynicism and present the results of two studies to test the hypotheses that (a) cynicism about an organizational change is distinguishable from skepticism about the change, more general forms of cynicism (disposition and management), and trust in management, (b) change-specific cynicism and skepticism relate differently to personal and situational antecedent variables, and (c) change-specific cynicism accounts for variance in employees intention to resist change not explained by skepticism, trust, and more general forms of cynicism. Study 1 was conducted with employees (N=65) from several organizations undergoing various changes, and Study 2 with employees (N=701) from a single organization undergoing restructuring and culture change. Results were generally consistent with prediction. Implications for future research and for the management of change are discussed.     

Analyzing Thorndike's Law Of Effect: The Question Of Stimulus-response Bonds

The stimulus—response bond postulated by Thorndike's (1911) law of effect is not required in a functional account of behavior in relation to its consequences. Moreover, the notion of a bond has been challenged by the findings of several experiments. Nevertheless, it remains viable in the light of reanalyses of those findings. Thorndike's suggestion that the strength of the bond depends on the magnitude of satisfaction is consistent with current research on resistance to change.