Treatment of resistance to change in children with autism

“Resistance to change” represents a core symptom of autism that we conceptualized and assessed as resulting in part due to factors known to govern free‐operant choice. During a free‐choice baseline, participants chose between problematic, resistive responses and an appropriate alternative response. During the asymmetrical‐choice condition, we delivered their most highly preferred item if the participant chose the alternative response (i.e., differential reinforcement of alternative behavior [DRA]). During the guided‐ (Experiment 1) and singular‐ (Experiment 2) choice conditions, we prompted participants to choose the alternative response and then delivered their most highly preferred item (i.e., DRA with escape extinction). All participants learned to tolerate (Experiment 1) or choose (Experiment 2) the alternative response when we combined DRA with escape extinction. After exposure to escape extinction, two participants showed strong maintenance effects with DRA alone. We discuss these finding relative to the effects of DRA and escape extinction on resistance to change.     

未雨绸缪：变革前非正式信息对员工变革抵制意愿的影响

组织变革前总会有小道消息等非正式信息传播, 这些信息是员工提前了解变革的重要来源。研究探索变革前非正式信息对员工变革前抵制意愿的影响, 以及员工变革抵制意愿随时间推移的变化。基于255位样本数据的结构方程模型及多层次线性增长模型分析表明：(1)变革前非正式信息的消极性及不完整性, 显著负向影响员工变革认知, 进而使员工变革抵制意愿上升; (2)随着时间推移, 员工变革抵制意愿显著衰减, 即从变革前到变革发生时抵制意愿显著降低。研究揭示了变革前非正式信息对员工有“热身准备”的作用, 能够帮助员工提前适应, 从而更好地应对变革。研究结果有助于变革的顺利实施。     

核苷类似物治疗慢性乙型肝炎中的耐药及治疗决策

尽管核苷类药物做为慢性乙型肝炎抗病毒治疗的一线用药广泛应用于临床多年,但随着用药时间的延长,治疗过程中出现了耐药这个极具挑战性的问题。核苷类药物的联合治疗或许能阻止或延缓耐药发生。     

Use of the Group Therapist's Personality Via the Countertransferences

Rather than use the term therapist personality, the author uses an operational definition of countertransference to examine the intersubjective field between group therapist and individual patients, the group, and subgroups. Differentiating between objective and subjective countertransferences, the author traces their sources to the transferences and resistances that arise from individuals, subgroups, and the group-as-a-whole. The transferences, resistances, and their related countertransferences are then integrated with enactments and history to create interventions. The charismatic leader makes no differentiation between the countertransferences and primarily acts on impulse or a rigid system.     

Using High-Probability Request Sequences to Increase Journal Writing

Written expression is a key aspect of academic success. Programs to enhance writing skills often rely on a feedback loop that consists of student production (i.e., get something on paper) and teacher feedback. Unfortunately, some students fail to produce enough written product so that the teacher can give constructive feedback. The purpose of this study was to examine two methods to increase the written word production of four students with difficulties in written expression. In the verbal prompt condition, students were given verbal prompts by their teacher to resume writing in their journals after the student stopped writing for approximately one min. In the high-p request condition, the teacher asked students to write a series of three words that typically occasioned compliance prior to asking the student to resume journal writing. Both interventions were assessed within the context of verbal praise and no verbal praise. Results suggested that both interventions increased the number of words written, particularly in the verbal praise condition. However, the high-p request sequence was more efficient and produced writing behavior that was more persistent across sessions. Results are discussed within the context of the theory of behavioral momentum.     

Buying cars online: the adoption of the web for high‐involvement,high‐cost purchases

This research explores the adoption of the Web throughout the buying process within high‐value, high‐involvement product categories (the car sector). Diffusion of innovations (Rogers, 1983) and innovation resistance Ram and Sheth (1989) theories are utilised and found to be useful. The research is exploratory, based on eight qualitative, semi‐structured individual interviews with potential car buyers. Findings indicate that there is resistance to adopting online car purchase overall, but relative advantage is recognised at the early, information seeking stages. Consumers use the Web to improve the balance of power between themselves and car salespeople. Innovation resistance during later stages, result from the need for personal experience of the product prior to purchase, ie test driving, as well as the uncertainty regarding after‐sales support. Further resistance comes from a reluctance to give up the social aspects of car buying and a perceived inability to negotiate with websites. It is suggested that organisations operating in these markets should focus Web activities on information provision, or opt for a hybrid strategy using both online and offline channels. Copyright © 2002 Henry Stewart Publications.     

如何才能保持拉米夫定的疗效及降低耐药——临床优化治疗策略

探讨拉米夫定的临床优化治疗策略,包括选择适用人群,用药最佳时机,预防和应对耐药的方法。旨在提高和保持拉米夫定在慢性乙型肝炎抗病毒治疗的效果。     

序贯疗法根除幽门螺杆菌

幽门螺旋杆菌（HP）感染是胃炎、消化性溃疡、胃癌和胃黏膜相关淋巴组织淋巴瘤的主要病因,根除HP具有重大的临床意义。随着抗生素耐药株HP逐年增加,HP根除率日益下降,因此出现了一种新的HP根除方案——10天或14天序贯疗法。此疗法指前5天或7天的诱导期中应用质子泵抑制剂（PPI）加一种抗生素的二联治疗,随后5天或7天应用PPI和两种抗生素的三联治疗。目前除少数研究外,绝大多数临床研究表明序贯疗法能够获得比传统的7天或10天三联疗法更高的HP根除率,其具体机制尚不明确。目前大部分相关的研究为单中心、样本量少,缺乏双盲对照,未能评估抗生素耐药性,尚待大样本、多中心、随机双盲对照的临床研究来进一步证实该疗法的有效性和安全性。