干预胆碱M受体对药物成瘾的影响及其与多巴胺的关系

药物成瘾是一类精神及行为障碍, 涉及到中枢神经系统的病变。毒蕈碱受体(Muscarinic receptor, M受体)属于胆碱能受体, 分5种亚型。行为学研究表明, 干预M受体能有效影响药物成瘾行为, 但其神经机制还亟待探索。阿片类药物与精神活性药物均能激活中枢多巴胺系统, 而M受体与多巴胺系统在多个脑区产生了交互作用。其中激动M2及M4受体抑制了多巴胺系统功能, 而激动M5受体增强了多巴胺系统功能, 与干预M2、M4、M5受体对药物成瘾行为的影响相对应。以上证据提示, 干预M受体可能通过影响多巴胺系统对药物成瘾起作用。     

Using Community Partnerships to Better Understand the Barriers to Using an Evidence‐Based,Parent‐Mediated Intervention for Autism Spectrum Disorder in a Medicaid System

Service use disparities have been noted to impede under‐resourced families' ability to access high‐quality services for their child with autism spectrum disorder (ASD). These disparities are particularly relevant for parent‐mediated interventions and may suggest a lack of fit between these interventions and the needs of under‐resourced community settings. This study used Roger's Diffusion of Innovations theory to guide community partnerships aimed at understanding the perceived compatibility, complexity, and relative advantage of using an evidence‐based, parent‐mediated intervention (Project ImPACT) within a Medicaid system. Three focus groups were conducted with 16 Medicaid‐eligible parents, and three focus groups were conducted with 16 ASD providers operating within a Medicaid system. Across all groups, parents and providers reported general interest in using Project ImPACT. However, primary themes emerged regarding the need to (a) reduce the complexity of written materials; (b) allow for a more flexible program delivery; (c) ensure a strong parent–therapist alliance; (d) involve the extended family; and (e) help families practice the intervention within their preexisting routines. Results are discussed as they relate to the design and fit of evidence‐based, parent‐mediated interventions for under‐resourced community settings.     

“人体器官移植工作体系”框架的初步构想及其伦理使命

借鉴国内外相关成功经验,结合我国实际情况,对“人体器官移植工作体系”的构成以及各系统职能进行初步探讨。研究了该体系在阻止人体器官商业化、提高人体移植器官分配的公平高效性等方面发挥的作用。     

Evaluating dialectical structures with Bayesian methods

This paper shows how complex argumentation, analyzed as dialectical structures, can be evaluated within a Bayesian framework by interpreting them as coherence constraints on subjective degrees of belief. A dialectical structure is a set of arguments (premiss-conclusion structure) among which support- and attack-relations hold. This approach addresses the observation that some theses in a debate can be better justified than others and thus fixes a shortcoming of a theory of defeasible reasoning which applies the bivalence principle to argument evaluations by assigning them the status of being either defeated or undefeated. Evaluation procedures which are based on the principle of bivalence can, however, be embedded as a special case within the Bayesian framework. The approach developed in this paper rests on the assumptions that arguments can be reconstructed as deductively valid and that complex argumentation can be reconstructed such that premisses of arguments with equivalent conclusions are pairwise independent.     

“认知科学”与“第二代认知科学”刍议

以计算隐喻为核心假设的传统认知心理学以及联结主义心理学均不能克服离身心智（disembodied mind）的根本缺陷,当代认知心理学正面临着新的范型转换。以具身性和情境性为重要特征的第二代认知科学将日受重视,并促使认知神经科学进入新的发展阶段。作者认为在身心关系上应该坚持生理只是心理的必要条件,而非充分条件的立场,克服生理还原论的危险;应该重新审视基于二元论的生理机制这种说法;心理学传统中的科学主义和人文主义有可能在第二代认知科学强调认知情境性的基础上达成某种融合;第一代认知科学对意识的研究是不成功的,因为对知觉、注意、记忆、思维等心理过程的研究不能代替意识的研究,同时还应避免以意识内容的研究取代心理学研究的倾向。第二代认知科学中的动力系统理论关于变量（因素）之间的偶合（coupling）关系完全不同于变差分析中的变量之间的交互作用关系”,其动力系统模式可能更有助于破解意识的产生（涌现）之谜,并引发心理学研究的方法论的变革新潮。第二代认知科学的兴起将启发人们对身心关系、生理还原论、意识研究在心理学中的地位、人工智能对心智完全模拟的可能性等重大问题重新思考     

BTL—QZ—V1．1气质测试系统的修订

修订BTL-QZ-V1．1气质测试系统。对519名12—21岁男女学生进行了测量。结果发现：神经系统特性具有年龄差异,随年龄增长兴奋性、抑制性增强,灵活性、稳定性增高;12～14岁是其快速增长期,14～18岁为慢速增长期,18岁后为稳定期;神经系统的兴奋性、抑制性具有性别差异,男生强于女生;可将气质类型划分为10种,年龄和性别不影响气质类型的分布;除灵活性外,神经系统兴奋性、抑制性和稳定性的重测信度系数在0．6～0．8之间,且达到显著性水平;以80·8神经类型量表为效标,所得相关系数达中等程度。提示BTL-QZ-V1．1气质测试系统的评定需按年龄和性别分组进行,建立的分组标准较为准确科学,信度、效度较高,可以广泛应用。     

伊斯兰复兴思潮下的伊斯兰经济思想

20世纪上半叶,伊斯兰教复兴思潮迭起,穆斯林比以往更加明确,伊斯兰教依然是他们解决精神、政治、经济问题的行之有效的途径。20世纪中后期,伊斯兰复兴的浪潮在经济思想领域产生了两方面影响:其一,带动了伊斯兰经济思想的研究。其二,促成了伊斯兰金融体系的建立。     

Bearing the unbearable: ancestral transmission through dreams and moving metaphors in the analtyic field

Abstract: This paper explores how untold and unresolved intergenerational trauma may be transmitted through unconscious channels of communication, manifesting in the dreams of descendants. Unwitting carriers for that which was too horrific for their ancestors to bear, descendants may enter analysis through an unconscious need to uncover past secrets, piece together ancestral histories before the keys to comprehending their terrible inheritance die with their forebears. They seek the relational containment of the analytic relationship to provide psychological conditions to bear the unbearable, know the unknowable, speak the unspeakable and redeem the unredeemable. In the case of ‘Rachael’, initial dreams gave rise to what Hobson (1984) called ‘moving metaphors of self’ in the analytic field. Dream imagery, projective and introjective processes in the transference‐countertransference dynamics gradually revealed an unknown ancestral history. I clarify the back and forth process from dream to waking dream thoughts to moving metaphors and differentiate the moving metaphor from a living symbol. I argue that the containment of the analytic relationship nested within the security of the analytic space is a necessary precondition for such healing processes to occur.     

Development of the Social Behavior of Two Mice Species With Contrasting Social Systems

The house mouse (Mus musculus) and the mound‐building mouse (M. spicilegus) differ in their mating and social systems. The M. musculus is polygynous and females tend to breed cooperatively while M. spicilegus is known to be monogamous and famous for its unique cooperative behavior; the communal overwintering. Mus spicilegus is considered as a highly aggressive species in the genus Mus. In the present study, we attempted to analyze the development of aggressive and sociable behavior in these species and to discover how familiarity with the target moderates the development of sociable and aggressive behaviors and moderates the differences between the species. Dyadic social interaction tests in neutral cages were performed on 21‐, 60‐, and 120‐day‐old mice of both genders and both species. Each individual was tested against a sibling and an unfamiliar individual at all three ages. Our results showed that the development of aggressive and sociable behavior with age differed between the species and sexes; however, familiarity with the other mouse moderated the effect of species on aggression. At 21 days, both genders of M. spicilegus were more aggressive against strangers than siblings. This became true of both species at 60 days. When facing a stranger, both sexes of M. spicilegus were more aggressive than M. musculus at 120 days. However, when facing a sibling, neither gender of M. spicilegus was more agonistic than M. musculus, indicating that either kinship or early social experiences elicit tolerance. Aggr. Behav. 38:288‐297, 2012. © 2012 Wiley Periodicals, Inc.