Association rule learning in neuropsychological data analysis for Alzheimer’s disease

Efficient methods of analysis readily available for clinicians continue to be limited within neuropsychological assessment at the raw data level. Here, a novel approach for generating predictive response patterns and analysing neuropsychological raw data is offered. In order to assess the usefulness of association rule learning as an analysis tool for neuropsychological raw data, Frequent Pattern Growth (FP-Growth) was used to mine patterns from the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Battery (CERAD-NB) database. Complete assessment data for 84 post-mortem confirmed Alzheimer’s disease (AD) cases and 294 age, race, and education matched controls were analysed across baseline and one-year follow-up using FP-Growth, for the purpose of assessing the clinical utility of a finer analysis at the raw data level and the feasibility of predicting response patterns for clinical/control groups. Output from FP-Growth, in terms of the number of frequent itemsets retained across both evaluation timepoints, was discernable between controls, mild, and moderate to severe Alzheimer’s disease cases (p < .001, and η² = .488). Patterns within raw data scores, both in terms of frequent itemsets and predictive association rules, appear to be differentiable across groups within neuropsychological analysis, which indicates that FP-Growth is applicable as a supplementary analysis tool for neuropsychological assessment by means of offering an additional level of data analysis, predictive item response capabilities, and aiding in clinical decision making.     

The ontology of character traits in Hume

This paper argues that Hume can account for character traits as lasting mental qualities without violating his reductionist account of the mind as a changing bundle of ideas and impressions. It argues that a trait is a disposition to act according to certain passions or motivations, explained entirely with reference to the ideas and impressions constituting one's current self. This account is consistent with Hume's view of the mind, and relies solely on his accounts of the association of impressions and ideas, and of the relationship between belief and passion, to establish relations that can properly be called lasting mental qualities.     

The uses of humor in life,neurosis and in psychotherapy: Part 2

Abstract

The first part of the paper focused on the dynamics of wit in life, literature, and psychoanalysis; the second part of this paper is devoted to the use of humor in therapy. The central concept is Freud's psychoanalytic method, as distinguished from Freud's various theories of disorder, or neurosis, with a further elaboration of Freud's inherently interpersonal conception of the analytic process, already present in the cathartic phase of the therapeutic technique. The cathartic, or discharge, function of humor is connected to reciprocal free association (a term coined by the author) to define the mutual and reciprocal free association in analysand and analyst, playing an essential role in the genesis of insight and interpretation. Humor has its role in loosening repression, facilitating the emergence of unconscious emotions and ideas, bringing to light character defenses, and thus driving the process of analysis.     

The analysand and analyst team practicing reciprocal free association: Defenders and deniers

Abstract

By 1900, Freud had formulated an original and operational method of psychoanalytic treatment and research: the technique of free association. In 1912–1915 and later writings, he recommended it as a fundamental procedure and process, called the fundamental rule, in psychoanalytic therapy. In recent years, free association as a method has been variously misrepresented, misunderstood, and denied by some schools of psychoanalysis. This paper reviews the history of free associations and argues for upholding the continuity and relevance of Freud's fundamental methodology and for a renewal of interest in reciprocal, i.e., interactive and interpersonal, free association.     

The association between dopamine D4 receptor exon III polymorphism and intensity of PTSD symptoms among flood survivors

Abstract

Thanks to the development of molecular genetics methods it is now possible to look for the genes which may contribute to posttraumatic stress disorder (PTSD). Polymorphism located in exon III of dopamine receptor type 4 (DRD4) gene was related to maladaptive stress responses as well as temperament traits related to PTSD. This study analyzed the association between the variable number tandem repeat (VNTR) DRD4 exon III polymorphism and intensity of PTSD symptoms in 107 (57 women and 50 men) survivors of a flood aged 14–62. Intensity of PTSD symptoms was measured using PTSD-F and PTSD-C questionnaires. Multivariate analysis of covariance (MANCOVA) was conducted to test the main and interactive effects of genotype and level of trauma exposure. Participants with at least one copy of the DRD4 long allele (seven or eight repetitions) had more intense PTSD symptoms on the Avoidance/Numbing scale (Cohen's f = .22) and the Total Scale (Cohen's f = .2) of the PTSD-F than participants who did not have these alleles in genotype. The results must be treated with caution, however, due to methodological restrictions and they need to be replicated on a larger sample.     

The Executive Manager and His or Her Organisation

Thoughts based on an inquiry and on experiences from my practice as a consultant, manager and company executive.     

防艾宣传大学生对艾滋病患者的内隐态度与交往意愿

目的：探讨大学生防艾宣传者对艾滋病患者的内隐态度。方法：采用自编大学生与艾滋病患者交往意愿调查问卷,通过测量获得对艾滋病患者有较高交往意愿的防艾宣传者100名,并随机抽取其中30名作为实验被试,完成了两组内隐联想测验（IAT）。结果：当艾滋病相关词与普通正性词相联以及非艾滋类乙型传染病与普通负性词相联时,其平均反应时低于艾滋病与一般消极性词相联及非艾滋类乙型传染病与普通正性词相联时的反应时;当艾滋病相关词与正性人际词相联以及非艾滋类乙型传染病与负性人际词相联时,其平均反应时与艾滋病和负性人际词相联及非艾滋类乙型传染病与正性人际词相联时的反应时无统计学意义的差异。结论：大学生防艾宣传者对各类传染病患者的内隐交往意愿处于同一水平,但相对于非艾滋类乙型传染病而言,其对艾滋病患者的消极厌恶水平较低。     

Linking mind,body and language: free association revisited

Psychoanalysis differs from other theories because of the great significance it attributes to a man's unconscious. Psychoanalysis differs fundamentally from other therapeutic methods in its use of free association and the significance and power it gives to this method when investigating unconscious phenomena. The present article begins with a brief review of the history of free association and its use as a method. After that, I discuss the relationship between free association and memory, neuropsychoanalysis and semiotics. Free association is linked with implicit memory and seen as a way of remembering; unconscious experiences are given a verbal form with the help of free association. The psychoanalytical setting and transference together constitute a psychic space, in which it becomes possible for the patient to get into touch with his or her bodily, psychic and verbal experiences and material simultaneously. The author sees free association specifically as a form of mental processing which is typical to psychoanalysis; it is a core process where the experiences of mind, body and language and their expressions link together. Free association is simultaneously the result of a memory activity and creative activity and, above all, a combination or synthesis of these two processes.     

Semantic priming in French children with varying comprehension skills

Semantic priming was analysed in two groups of French children contrasted on comprehension skills with a visual lexical-decision task using a long SOA (800 ms). Two relation types between related primes and targets were examined: pure semantic relation (categorical vs. functional), and lexical association strength (strong vs. weak). Targets were preceded by related, unrelated, and neutral primes. Skilled comprehenders showed semantic priming only for category-related words, whatever their association strength, and without any evidence of an associative boost. Less-skilled comprehenders also showed semantic priming for category-related words, irrespective of their association strength, but with an indication of an associative boost. They also displayed semantic priming for function-related awords that are strongly associated, but not for those that are weakly associated. These results are discussed within the theoretical frame proposed by Plaut and Booth (2000 Plaut, D. C. and Booth, J. R. 2000. Individual and developmental differences in semantic priming: Empirical and computational support for a single-mechanism account of lexical processing. Psychological Review, 4: 786–823.  [Google Scholar]).