Memory deficits in young schizophrenics with normal general intellectual function

The aim of the present study was to examine different dimensions of memory functioning in young schizophrenics with normal general intellectual abilities. Thirty-three patients with schizophrenia and 33 healthy controls were included in the study. The results suggest that immediate short-term memory is intact, though there emerged a working memory deficit in the schizophrenia group. Deficient encoding of verbal material was observed in some, but not in other, testing conditions. There also seemed to be a retrieval deficit for verbal material in schizophrenia, though no storage deficit was indicated. Impaired memory for non-verbal material was also revealed. These results occurred in a context of intact executive functioning as measured by the Wisconsin Card Sorting Test. The results indicate that temporal and frontal structures, as well as their interconnections, may be compromised in schizophrenia.     

积极情景线索对内隐攻击性的影响

通过向被试呈现代表积极情景线索的材料(一段含有互助、和谐信息的公益短片),运用内隐联想测验(IAT)范式,从内隐社会认知的角度来研究积极情境线索对个体内隐攻击性的影响,并分析这种影响是否具有性别差异。结果表明:未观看积极情景线索材料的被试表现出显著的内隐攻击性,而观看积极情景线索材料的被试的内隐攻击性不显著;积极情景线索的主效应显著,且这一效应不存在性别差异。这说明,积极情景线索能有效抑制个体的内隐攻击性,并支持自我攻击信念IAT是测量个体内隐攻击性的有效工具。     

Impact of motivation on cognitive control in the context of vigilance lowering: an ERP study

We assessed the effects of time-on-task on cognitive control expressed by the CRN/Nc and the extent to which motivation modulates this relationship. We utilized two groups of participants, who were told that their performance would (evaluation condition) or would not (control condition) be evaluated online. Both groups performed a version of the Eriksen Flanker Task for 60 min. We observed classical vigilance lowering, manifested by a progressive performance decline with time-on-task, in the control, but not in the evaluation, condition. In the latter, performance remained stable throughout the task. ERP analysis indicated the same interaction in our main component of interest, the CRN/Nc, whose amplitude decreased from the first to the last period in the control condition but remained stable over time in the evaluation condition. To our knowledge, this study is the first to demonstrate the impact of motivation on monitoring processes as indexed by the correct response negativity, in the context of a prolonged task. Vigilance lowering caused by a repetitive and prolonged flanker task, results in compromised response control and compromised control of correct responses. Our results suggest that alterations in ACC functioning may underlie vigilance decline and can be viewed as evidence that the action monitoring functions of the ACC can be positively affected by motivation.     

The Occipital Cortex in the Blind

ABSTRACT— Studying the brains of blind individuals provides a unique opportunity to investigate how the brain changes and adapts in response to afferent (input) and efferent (output) demands. We discuss evidence suggesting that regions of the brain normally associated with the processing of visual information undergo remarkable dynamic change in response to blindness. These neuroplastic changes implicate not only processing carried out by the remaining senses but also higher cognitive functions such as language and memory. A strong emphasis is placed on evidence obtained from advanced neuroimaging techniques that allow researchers to identify areas of human brain activity, as well as from lesion approaches (both reversible and irreversible) to address the functional relevance and role of these activated areas. A possible mechanism and conceptual framework for these physiological and behavioral changes is proposed.     

论述理解中逻辑有效与逻辑无效条件推理的研究

句法理论和心理模型理论是解释论述理解中逻辑有效 (如MP)与逻辑无效 (如AC)条件推理机制的两种不同观点。本研究通过两项实验旨在对这两种理论加以检测。实验要求被试阅读遵循MP或AC形式的故事后对故事结论的正确性做出判断。结果表明 ,在论述理解中 ,条件前提的语义联系强度影响MP推理 ;深思熟虑对MP和AC推理均产生影响。研究结果支持心理模型理论。     

Visuospatial and mathematical dysfunction in major depressive disorder and/or panic disorder: A study of parietal functioning

The parietal cortex is critical for several different cognitive functions, including visuospatial processing and mathematical abilities. There is strong evidence indicating parietal dysfunction in depression. However, it is less clear whether anxiety is associated with parietal dysfunction and whether comorbid depression and anxiety are associated with greater impairment. The present study compared participants with major depression (MDD), panic disorder (PD), comorbid MDD/PD and controls on neuropsychological measures of visuospatial processing, Judgement of Line Orientation (JLO), and mathematical abilities, Wide Range Achievement Test (WRAT) Arithmetic. Only comorbid MDD/PD was associated with decreased performance on JLO, whereas all psychopathological groups exhibited comparably decreased performance on WRAT Arithmetic. Furthermore, the results were not accounted for by other comorbid disorders, medication use or psychopathology severity. The present study suggests comorbid depression and anxious arousal are associated with impairment in visuospatial processing and provides novel evidence indicating mathematical deficits across depression and/or anxiety. Implications for understanding parietal dysfunction in internalising psychopathology are discussed.     

Nonparametric IRT: Testing the bi-isotonicity of isotonic probabilistic models (ISOP)

Nonparametric tests for testing the validity of polytomous ISOP-models (unidimensional ordinal probabilistic polytomous IRT-models) are presented. Since the ISOP-model is a very general nonparametric unidimensional rating scale model the test statistics apply to a great multitude of latent trait models. A test for the comonotonicity of item sets of two or more items is suggested. Procedures for testing the comonotonicity of two item sets and for item selection are developed. The tests are based on Goodman-Kruskal's gamma index of ordinal association and are generalizations thereof. It is an essential advantage of polytomous ISOP-models within probabilistic IRT-models that the tests of validity of the model can be performed before and without the model being fitted to the data. The new test statistics have the further advantage that no prior order of items or subjects needs to be known.     

Regulation of glutamate synapses by nicotinic acetylcholine receptors in auditory cortex

Acetylcholine plays an important role in regulating the processing of sensory stimuli, and understanding its specific cellular actions is critical to understanding how sensory cortex develops and functions in different behavioral states. Here we review recent work on the cellular effects of nicotinic receptor activation in auditory cortex and describe how these actions could affect systems-level auditory function. In particular, we describe a novel function of nicotinic acetylcholine receptors to regulate glutamate synapses containing N-methyl-D-aspartate receptors during early postnatal development. The transient regulation of developing glutamate synapses also defines a window of vulnerability during which exposure to exogenous nicotine disrupts synapse development. Thus, it appears that nicotinic regulation of glutamate synapses is a critical feature of auditory cortex development.     

A further note on freeman's measure of association

This note extends and elaborates Hubert's attempt to provide an interpretation of Freeman's measure of association,. The measure is used in a a contingency table when observations are ordered on one variable and unordered on the other. No attempt is made explore the distribution of.