心肌保护基因治疗进展及展望

心肌保护基因治疗的研究目前仍停留在动物实验阶段。本文从哲学的角度论述了心肌保护基因治疗研究的进展与优点,以及存在的安全性、局限性与伦理学方面的问题,并就目前其它领域基因治疗的进展对其作了进一步的展望。     

Treatment effectiveness of combined medication/behavioural treatment with chinese ADHD children in routine practice

BACKGROUND: The effectiveness of a combined methylphenidate/behavioural treatment (BT) versus methylphenidate-only for Chinese children with Attention-Deficit/Hyperactivity Disorder (ADHD) was tested in routine clinical practice in Hong Kong. METHODS: A randomized group comparison design was adopted with two treatment conditions (methylphenidate-only; methylphenidate/BT), which lasted for 6 months. There were four assessment time points (pre-treatment, post-treatment, and 6-month and 12-month follow-ups), using the Strengths and Weaknesses of ADHD Symptoms and Normal Behaviours (SWAN) Rating Scale. Parental attitude toward different treatment options of ADHD was also assessed at pre-treatment and post-treatment. Participants included 90 Chinese ADHD children (mean age=8 years, SD=.95). RESULTS: The combination of BT and a low-dose methylphenidate was significantly more effective than methylphenidate-only in reducing ADHD and ODD symptoms at post-treatment. At follow-ups, the benefits of the combined treatment were maintained, while the methylphenidate-only group caught up in improvement in ADHD symptoms. Parents in both treatment conditions showed improved attitude toward medication after the 6-month treatment phase, while their attitude toward BT was positive all along. CONCLUSIONS: This study supported the added benefits of BT, on top of medication, for Chinese ADHD children in routine practice with treatments conducted by regular medical and paramedical staffs.     

学习压力引发焦虑情绪的咨询——我是一位“笨”女孩

本案例是一位刚入学的研究生,由于是跨专业读研,学习统计,实验有点吃力,担心自己做不出科研成果。从而压力大,情绪低落,认为自己是位"笨"女孩。咨询师主要运用认知疗法,帮助其调整认知观念,运用合理情绪疗法对求助者心理问题进行了分析,改善其适应不良情绪,咨询效果明显。     

Solution-Focused Brief Therapy and the Kingdom of God: A Cosmological Integration

The core cosmological dimension of Solution-Focused Brief Therapy (SFBT) and Christianity emphasizes a similar truth—the future is now. As humans live in their preferred realities, they experience the future, problem free solution for their lives from a SFBT perspective. The Christian tradition emphasizes the in-breaking Kingdom of God beginning with the Christ event. The end has entered the now. However, the final consummation of the end-times is still as yet in the future which means that sin and death are part of the world. This Christian understanding of sin and fallenness provides humility to SFBT’s inherently positive view of the world (Bidwell, D. R. Am J of Pastor Couns, 3:3–21, 1999), while SFBT encourages Christians to see the kingdom of God in the now instead of the future.     

内观疗法对情绪体验影响的ERP研究

采用事件相关电位技术(ERPs)考察内观疗法对情绪体验影响的变化特点,以探明内观疗法是否引起情绪体验的变化。结果表明,内观组在400-1100ms平均波幅显著大于对照组,在内观组和对照组间,出现了显著的组间差异。由此得出结论,说明了内观疗法对情绪体验产生了影响,主要体现在情绪体验的深度与弥散性上。     

我国病毒疫苗研发战略的几点思考

对我国目前病毒性疫苗的研发战略问题进行探讨。提出应根据我国目前的经济发展水平及公众基本卫生保健措施的实施情况,在病毒性疫苗的开发研究中必须坚持有所为有所不为的原则,将有限的公共卫生资源向预防性病毒疫苗的研发倾斜;对于抗病毒药物开发的投入,主要应由制药厂商承担;在疫苗的研制中重点保证常见传染病的传统疫苗的研制,新疫苗的研发重点应放在那些传统疫苗不能奏效及传统疫苗的改造上,而对于病毒基本生物学特征的研究及新出现的病毒性传染病疫苗的研究仅对国家顶尖级实验室给予资助,以便及时应对由新发现病毒所造成的重大疫情及国际上在该领域的重大突破;同时,应根据国情尽快制定和完善疫苗研发、生产、使用的质量标准及立法,以保证疫苗生产厂商的权益。     

Universal Selection Theory: Implications for multidisciplinary approaches to clinical psychology and psychiatry

Universal Selection Theory claims that the increases in the fit of a system to its environment are achieved through a process of blind variation and cumulative selection that is analogous to evolution by natural selection. The process is proposed to occur in many domains, including the gene, behavior, cognition, and culture (meme). This paper reviews the background for the theory and explains how it may contribute to clinical psychology and psychiatry. It is suggested that the theory provides: A framework for integrating biological, psychological and cultural perspectives; an account for why problem-solving and cognitive reappraisal prove to be effective interventions; and an understanding of why psychological disorders can be resistant to change. Implications for psychological treatments, theoretical integration, and future research are discussed.     

Distinguishing Between Conceptualizations of Attachment: Clinical Implications in Marriage and Family Therapy

Authors described four distinct conceptualizations of the construct of attachment and identified clinical implications associated with each. Three of the conceptualizations, which are influenced by the work of Bowlby and Ainsworth, seem to have some empirical support; these conceptualizations are compatible with systemic and social constructionist approaches to family therapy. The other conceptualization— Reactive Attachment Disorder (RAD)—contradicts the extensive body of literature associated with the Bowlby/Ainsworth traditions and tends to pathologize children. Therefore, family therapists interested in attachment are encouraged to maintain conceptual clarity in their clinical work and are further encouraged to rely on clinical conceptualizations and interventions that are consistent with the work of Bowlby and Ainsworth.     

Work and Family Balance Among Dual-Earner Working-Class Mexican-Americans: Implications for Therapists

The ability to balance work and family demands can affect marital satisfaction, family cohesion, and job satisfaction. While most research in this area has utilized middle-class Anglo-American samples, the present investigation examined dual-earner, working-class Mexican- Americans. Positive relationships were found between work-family balance and satisfaction with marriage, family life and jobs with gender and acculturation showing moderating effects on some variables. Family therapists should be cognizant of the impact of work- family demands on marriage and family functioning even when working class minority families do not offer these issues as presenting problems.     

Fostering Client Creativity in Family Therapy: A Process Research Study

Creativity has been shown to enhance problem solving, and to increase flexibility and adaptability—qualities associated with positive therapeutic outcomes. Literature related to therapist and/or client creativity is primarily anecdotal. Empirical literature addressing how therapists can facilitate the creativity of their clients in family therapy is scarce. In this study, the researchers used process methodology to code the behavior of therapists and clients in 31 videotaped family therapy sessions. Results show a significant positive correlation between interventions that induce positive affect and the creative client behaviors of optimism and playfulness.