Neurocognitive impairment does not predict treatment outcome in obsessive-compulsive disorder

There is conflicting evidence pertaining to whether or not neurocognitive task performance at baseline predicts treatment response in obsessive-compulsive disorder (OCD). In the present study, we administered a set of executive neurocognitive tests with a putative sensitivity for treatment outcome to a sample of 138 OCD patients. Additionally, subjective neurocognitive dysfunction was determined via a questionnaire. All patients participated in a cognitive-behavioural treatment program (CBT). Results showed that responders (n = 73) did not differ from non-responders (n = 65) on any of the parameters except for decreased performance on the delayed alternation test (p < .1, effect size: .61). A subsidiary analysis revealed that slowing on the Trail-Making Test A and an enhanced rate of perserveration errors on the Wisconsin Card Sorting Test predicted poor outcome for the treatment of compulsions. It is concluded that neurocognitive impairment does not represent a reliable early warning sign for non-response to CBT.     

Deficit of preparatory attention in frontotemporal dementia

We studied preparatory attention in patients suffering from frontotemporal dementia in the beginning stages of the disease, using an experimental test developed by LaBerge, Auclair, and Siéroff (2000). In this experimental test, a distracter can appear while subjects have to prepare to respond to a simple target. The probability that a distracter can appear in a trial is varied across three blocks. Normal controls show an increase of response times to targets (slope) as a function of the distracter probability, preparatory attention to the target is reduced by the increase of the distracter probability. Patients suffering from frontotemporal dementia show a slope of response times which is more than twice as large as the slope obtained by their matched controls. Such an abnormal increase of response times to targets is interpreted as a deficit in preparatory attention. Patients also show more omissions than controls. We suggest that this deficit in preparatory attention is related to the frontal lesion presented by the patients and can result in higher distractibility, a symptom frequently encountered in these patients.     

IQ stability: the relation between child and young adult intelligence test scores in low-birthweight samples

The stability of IQ from childhood to adulthood in low-birthweight subjects was measured in two independent samples with follow-up intervals of approximately 14 and 9.5 years. In both samples, intelligence was assessed with the WISC at a mean age of 9.5. Twenty-six subjects were retested with the WAIS at a mean age of 23.5, and 78 subjects with the BPP (the Danish Military Draft Board Intelligence Test) at the age of 19.1. Both samples obtained childhood and adult test scores below the expected means. For the Wechsler Verbal, Performance and Full-Scale IQs, the stability quotients were 0.86, 0.86, and 0.89 in the WAIS sample, and the retest correlations for the three IQs with the BPP score were 0.66, 0.65, and 0.74. Thus, the majority of children showed stable patterns of intellectual development from middle childhood to young adulthood.     

任务难度对基于位置返回抑制时间进程的影响

在返回抑制的实验范式下,采用线索一靶子模式进行了视觉字母觉察实验、实验发现,返回抑制在线索与靶子之间的时间间隔（ＳＯＡ）为７００ｍｓ时出现,且在９００ｍｓ时消退。这与先前许多实验发现的返回抑制在ＳＯＡ为３００ｍｓ左右时出现的结果不一致。作者认为,实验任务的难度是影响返回抑制时间进程的一个重要因素。     

时点,时距和时序信息加工之间相关性研究

本研究分为两个实验,分别采用预期式和回溯式范型,探讨时距、时序和时点三者之间信息加工的相关性,结果发现：同一时间经历,时距估计与时序判断随注意参与程度的增加,由负相关趋势向正相关变化;时距估计与时点离散度可能呈正相关趋势;时序判断与时点离散度随注意参与程度的增加,由负相关趋势向正相关变化。     

A Gabbay-Rule Free Axiomatization of T×W Validity

The semantical structures called T×W frames were introduced in (Thomason, 1984) for the Ockhamist temporal-modal language, _O, which consists of the usual propositional language augmented with the Priorean operators P and F and with a possibility operator . However, these structures are also suitable for interpreting an extended language, _SO, containing a further possibility operator ^s which expresses synchronism among possibly incompatible histories and which can thus be thought of as a cross-history simultaneity operator. In the present paper we provide an infinite set of axioms in _SO, which is shown to be strongly complete forT ×W-validity. Von Kutschera (1997) contains a finite axiomatization of T×W-validity which however makes use of the Gabbay Irreflexivity Rule (Gabbay, 1981). In order to avoid using this rule, the proof presented here develops a new technique to deal with reflexive maximal consistent sets in Henkin-style constructions.     

Developmental changes in associations between auditory-visual events

The goal of the present study was twofold: to examine the influence of two amodal properties, co-location and temporal synchrony, on infants' associating a sight with a sound, and to determine if the relative influence of these properties on crossmodal learning changes with age. During familiarization 2-, 4-, 6- and 8-month-olds were presented two toys and a sound, with sights and sounds varying with respect to co-location and temporal synchrony. Following each familiarization phase infants were given a paired preference test to assess their learning of sight-sound associations. Measures of preferential looking revealed age-related changes in the influence of co-location and temporal synchrony on infants' learning sight-sound associations. At all ages, infants could use temporal synchrony and co-location as a basis for associating an auditory with a visual event and, in the absence of temporal synchrony, co-location was sufficient to support crossmodal learning. However, when these cues conflicted there were developmental changes in the influence of these cues on infants' learning auditory-visual associations. At 2 and 4 months infants associated the sounds with the toy that moved in synchrony with the sound's rhythm despite extreme violation of co-location of this sight and sound. In contrast, 6- and 8-month-olds did not associate a specific toy with the sound when co-location and synchrony information conflicted. The findings highlight the unique and interactive effects of distinct amodal properties on infants' learning arbitrary crossmodal relations. Possible explanations for the age shift in performance are discussed.     

Ratio versus difference comparators in choice.

Several theories in the learning literature describe decision rules for performance utilizing ratios and differences. The present paper analyzes rules for choice based on either delays to food, immediacies (the inverse of delays), or rates of food, combined factorially with a ratio or difference comparator. An experiment using the time-left procedure (Gibbon & Church, 1981) is reported with motivational differentials induced by unequal reinforcement durations. The preference results were compatible with a ratio-comparator decision rule, but not with decision rules based on differences. Differential reinforcement amounts were functionally equivalent to changes in delays to food. Under biased reinforcement, overall food rate was increased, but variance in preference was increased or decreased depending on which alternative was favored. This is a Weber law finding that is compatible with multiplicative, scalar sources of variance but incompatible with pacemaker rate changes proportional to food presentation rate.