Measuring merit in animal research

Merit review of scientific projects involving laboratory animals is a central issue in the current debate over the ethics of animal experimentation. In this essay, I examine several conceptual, regulatory, and practical problems inherent in the merit review process. Contemporary challenges to the existing merit review system and suggestions for reform are also discussed. The essay concludes with comments on legal and political questions relevant to the future of merit assessment.     

The pigeon's perception of saturation.

Three experiments used similar methods to investigate the pigeon's perception of saturation of monochromatic lights. This trial-wise procedure consisted of brief presentations of positive and negative stimuli in random sequence. Pecks to the positive stimuli were occasionally reinforced on a low fixed-ratio schedule. The first study determined absolute thresholds for "white" and monochromatic lights by establishing a discrimination between lights of various radiances and a dark key. Experiment II investigated generalization from a white light to various monochromatic lights under conditions that minimized the use of luminance as a cue. The third experiment examined discrimination of various monochromatic lights along a colorimetric purity continuum; responses to white light were reinforced, while responses to lights that combined white and monochromatic lights in various proportions were not. The results indicated that lights of different wavelength differ in saturation, but that all are discriminable from white. Wavelengths between 550 and 600 nm are least saturated for the pigeon, and saturation increases markedly as wavelength decreases below this region of the spectrum.     

A note on the nonmetric analysis of psychological intervals for an unknown ordering of stimuli

A modified version of a coordinate adjustment technique which permits the analysis of comparisons of psychological intervals for an unknown ordering of stimuli is described and compared to the original version and to TORSCA. For configurations with a large number of points, knowledge of the rank order of the stimuli does not improve the solution. For configurations with a small number of points, the performance of the new algorithm with an unknown ordering is equivalent to TORSCA.This research was supported by a grant from the Natural Sciences and Engineering Research Council of Canada.     

CAN A DECAY PROCESS EXPLAIN THE TIMING OF CONDITIONED RESPONSES?

To explain time-scale invariant distributions of response latencies, it appears to be necessary to postulate scalar noise in the remembered intervals, against which the subjective measure of the currently elapsing interval is compared. At least in some cases, the observed variability cannot be due to variability in the subjective intervals written to memory; it must come from noise (variability) in the reading of a memory. The Staddon and Higa proposal offers no explanation for the observed variability, and it is unclear what noise assumption would yield the observed variability, given their assumption that intervals are timed by a nonlinear decay process. The decay process cannot plausibly be represented by the logarithmic function, because it begins and ends at infinity. The assumption of any form of nonlinear timing is inconsistent with the most important result of the time-left experiment, which is that the changeover time increases linearly with the comparison-standard difference.     

Is the mind-body interface microscopic?

This paper puts forward the hypothesis that consciousness might be linked to matter in a way which is more sophisticated than the traditional macroscopic Cartesian hypothesis suggests.Advances in the biophysics of the nervous system, not only on the level of its macroscopic functioning but also on the level of individual ion channels, have made the question of how finely consciousness is tied to matter and its dynamics more important. Quantum mechanics limits the attainable resolution and puts into doubt the idea of an infinitely fine-woven attachment. A recent approach to physics rekindles such a rationalist hope. Endophysics focuses on the global implications of microscopic computer simulations of chemical and biophysical processes. A complete artificial universe can be set up in the computer. It produces non-classical and nonlocal effects inside — on the interface that exists between an internal observer (fluid neuron) and the rest of the world. This interface is finer than any brain property to which the status of the mind-body interface has been attributed hitherto. A new class of experiments becomes possible in the artificial world and, by analogy, in the real world. Magnetic resonance imaging experiments, routinely performed under open-loop conditions, can be repeated under psychophysical (closed-loop) conditions — in search for microscopically induced changes in the perceived and measured structure of the world.     

Reasonable Partiality to Domestic Animals

The paper deals with partiality flowing from special relationships. Two main problems are discussed. The first concerns the relationship between partiality and genuine moral obligations. If partiality can bring about such obligations only if it is reasonable, what requirements should it meet in order to be reasonable? The second problem is one of animal ethics. Can the concept of reasonable partiality help us articulate what is morally at stake in a current discussion about the treatment of domestic animals, viz. the European discussion about the castration of pigs?     

Animals and the Image of God in the Bible and Beyond

Abstract :  This article examines theological thought pertaining to the imago Dei doctrine in light of its relation to non-human animals within the framework of biblical, intertestamental Jewish, and early Christian writings. Evaluating theological understandings of human nature as they relate to and interact with theological and philosophical understandings of animals and animal nature, the author finds that the understandings of the image of God and dominion as they are ideally conceived in the Jewish and Christian Scriptures are significantly more closely related to the ideas of human-animal continuity, compassion, and responsibility than to human rationality or the human immaterial immortal soul (and the entailed implication of animals' lack thereof).     

A Christian Rationale for Vegetarianism

Abstract :  This article lays out an argument for vegetarianism based on a Christian theological rationale, specifically on a new articulation of a Christian anthropology for the 21^st century. What I suggest is that an exploration of what it means to be human in a contemporary first world context leads to the conclusion that vegetarianism is a logical expression of one's understanding of oneself as a Christian, and one's exercise of one's Christian faith and discipleship.     

The influence of perceptual and semantic categorization on inhibitory processing as measured by the N2–P3 response

In daily activities, humans must attend and respond to a range of important items and inhibit and not respond to unimportant distractions. Our current understanding of these processes is largely based on perceptually simple stimuli. This study investigates the interaction of conceptual-semantic categorization and inhibitory processing using Event Related Potentials (ERPs). Participants completed three Go–NoGo tasks that increased systematically in the degree of conceptual-semantic information necessary to respond correctly (from single items to categories of objects and animals). Findings indicate that the N2 response reflects inhibitory processing but does not change significantly with task difficulty. The P3 NoGo amplitude, on the other hand, is attenuated by task difficulty. Further, the latency of the peak of the P3 NoGo response elicited by the most difficult task is significantly later than are the peaks detected during performance of the other two tasks. Thus, the level of complexity of conceptual-semantic representations influences inhibitory processing in a systematic way. This inhibition paradigm may be a key for investigating inhibitory dysfunction in patient populations.