关于实验动物运动模型建立的伦理思考

基于目前广泛应用的动物实验伦理3R和5F原则,通过深入分析已有运动干预文献中的动物运动模型构建方法,分别就运动模型建立前实验动物的选取,运动模式、运动剂量的确定,模型建立过程中不同阶段不同运动形式所涉及的伦理问题,以及实验动物安乐死等各个方面进行伦理分析,探讨伦理关怀在动物运动模型建立中的必要性和重要性。运动模型的构建作为研究运动干预的关键环节是极其重要的,此建立过程中涉及到诸多动物实验伦理问题。

     

Disgust sensitivity and fear of animals: Effect of exposure to violent or revulsive material

Subjects were asked to rate their fear of four categories of animals both before and after viewing one of three brief video films. Subjects watched either (a) a video depicting extreme violence, (b) a video depicting revulsive scenes from a hospital operation, or (c) a video showing neutral landscape scenes. The results suggested that exposure to violent material produced an increase in fear ratings for animals in the Hi Fear/Hi Predatory category (e.g., lion, tiger, shark) which was significantly different from a decrease in fear ratings recorded for all other categories of animals. However, exposure to revulsive material produced an increase in fear ratings to animals in both the Hi Fear/Lo Predatory category (e.g., rat, spider, snake) and the Hi Revulsion category (e.g., slug, maggot, snail) which was significantly different to the decrease in fear ratings recorded for animals in the remaining categories. The neutral landscape scenes produced a decrease in mean fear ratings for all categories of animals. These results are considered further support for a disease-avoidance model of common animal fears, and suggest a causal link between disgust sensitivity and fear of certain fear-relevant animals.     

Characteristics of individuals with fear of spiders

Abstract

This paper reports the results of two studies which investigated some of the factors that differentiated individuals with fear of spiders from those without such fears. The main results suggested that (a) there was little evidence that fear of spiders in nonclinical subjects is normally acquired through direct conditioning experiences; (b) there was some evidence for a familial component to spider fears; (c) there was no support for the view that individuals reporting a fear of spiders were especially sensitized to the movement cues possessed by spiders; (d) fear of spiders was not associated either with higher levels of trait anxiety or with an increased predisposition to other fears in general; but (e) fear of spiders did appear to be associated with increased fear of other animals, but only animals that are normally considered fear-evoking or disgust-evoking. These results provide little support for a traditional conditioning view of spider fears, and they are not entirely consistent with some preparedness accounts of the acquisition of specific fears. However, the results do suggest that fear of spiders is part of a functionally integrated set of animal fears, and it is argued that the present results could be better understood by attempting to integrate predator-defence and disease-avoidance models of animal fears.     

“Age-associated memory impairment”: A critique

Abstract

This paper is a critical evaluation of the construct of age-associated memory impairment (AAMI) and the criteria for assigning the AAMI label. It is argued that AAMI should not be regarded as a clinical diagnosis; that the AAMI criteria fail to isolate selective memory impairments, ignore crucial longitudinal information, and are vague, arbitrary, and unreliable; that studies of memory loss should examine a wider range of subjects than those who meet the AAMI criteria-moreover, use of the criteria may impede research; and that treatment studies should await investigations of the biological antecedents of memory loss. Several recommendations address subject selection and assessment issues.     

Episodic memory and the hippocampus: it's about time

Several recent studies have sought to develop animal models of episodic memory, the capacity to recollect unique personal experiences. However, these studies have not yet provided unambiguous evidence that this capacity is based on recollection of the learning episodes. A recent study that examined memory for the ordering of events within unique experiences, and demonstrated a critical and selective role for the hippocampus, suggests a new and promising model for neurobiological analyses of episodic memory.     

THE ANIMAL BODY MULTIPLE: SCIENCE,RELIGION, AND THE INVENTION OF HALAL STUNNING

This article proposes a specific kind of ontological investigation in the field of science and religion. I argue that science and religion can create distinct practices that enact multiple realities, and thus they should be seen as more than different views of the same world. By analyzing the details of scientific experiments crucial for the invention of halal stunning, I demonstrate that religion and science are both permeable to the social, the biological, and to each other, and that seemingly incommensurable realities can co-occur in the body of an animal. Here, animals’ modes of existence are interdependent with the technologies being used, and with the web of interactions that they are drawn into. In the process of inventing halal stunning, it is not so much about the same animal body that is thought about differently as it is about animals spanning across multiple, physiological, realities as they are recruited into different webs of interactions to create a new slaughter method.     

Effects of the range and frequency of vibrations on the momentary riding comfort evaluation of a railway vehicle

When trains pass level-crossings, turnouts, and rail joints, they are momentarily subjected to extreme vibrations. In railway engineering, evaluation of the riding comfort under such occasional vibrations is called the momentary riding comfort evaluation, as distinct from the long-term evaluation, which addresses the riding comfort of passengers for certain lengths of train operation. In order to identify the effective vibrational characteristics of the momentary evaluation, an experiment was performed with a riding comfort simulator. Ten adult subjects for each condition, 80 in total, participated in the experiment. The effects of differences in the range of stimuli, frequency of each stimulus, and scores on a rating scale of discomfort were studied. Differences in the range and frequency affected the evaluation such that subjects tended to make a relative judgment on discomfort. They made almost an absolute judgment when the rating scale was well defined, with a small number of categories.     

Weigh(t)ing for Awareness

We wished to learn if weight perception can be extinguished by studying two patients with right hemisphere brain damage. When lifting weights simultaneously, a patient with right frontal damage was not biased in her judgments of which weight was heavier. By contrast, a patient with right parietal damage reported left-sided weights as being lighter than those on the right. Psychophysical power functions revealed that her awareness of increasing weights on the left was dampened compared to the right when lifting weights individually on each side. Strikingly, her awareness of weight changes on the left was completely abolished when she lifted weights in both hands simultaneously. She demonstrated an unusual split in awareness, being motorically aware of and actively engaged with left-sided weights while being unaware of their incremental changes.     

Perceptual learning effect on decision and confidence thresholds

Practice can enhance of perceptual sensitivity, a well-known phenomenon called perceptual learning. However, the effect of practice on subjective perception has received little attention. We approach this problem from a visual psychophysics and computational modeling perspective. In a sequence of visual search experiments, subjects significantly increased the ability to detect a “trained target”. Before and after training, subjects performed two psychophysical protocols that parametrically vary the visibility of the “trained target”: an attentional blink and a visual masking task. We found that confidence increased after learning only in the attentional blink task. Despite large differences in some observables and task settings, we identify common mechanisms for decision-making and confidence. Specifically, our behavioral results and computational model suggest that perceptual ability is independent of processing time, indicating that changes in early cortical representations are effective, and learning changes decision criteria to convey choice and confidence.     

Sexual Nature? (Re)presenting Sexuality and Science in the Museum

The past 15 years have seen dramatic changes in social norms around sex and sexuality in the UK and worldwide. In 2011, the London Natural History Museum (NHM) contributed to these debates by opening the temporary exhibition Sexual Nature, which aimed to provide ‘a candid exploration of sex in the natural world’ whilst also drawing in an under-represented audience of young adults. Sexual Nature provides an opportunity to explore Macdonald's ‘politics of display’ in the mutual construction of (public) scientific knowledge, society and sexuality, at a time of intense contestation over sexual norms. Whilst Sexual Nature both reflected and contributed to major reframings of sexuality and what science can say about it, the assumption that it would be possible to present this topic as morally neutral, reliable and uncontested, in line with traditions of public science, proved to be problematic. The language of the exhibition moved back and forth between human/animal similarity and difference, and between scientific and cultural tropes as the NHM tried to maintain epistemic authority whilst also negotiating the moral boundaries of acceptable sexual behaviour. The topic of sex pushed the museum far beyond its usual expertise in the natural sciences towards the unfamiliar territory of the social and human, resulting in an ad hoc search for, and negotiation with, alternative sources of expertise. Boon et al.’s co-curation approach to exhibition building has the potential to extend the NHM's audience-driven strategy, whilst also producing a more coherent and nuanced exhibition about the science of sex.