Memories defining the self in Alzheimer’s disease

ABSTRACT

There is a debate over the extent to which personal identity or the self is preserved in patients with Alzheimer’s disease (AD). Autobiographical memory deficits at early stages of AD could contribute to altering patients’ self. However, the nature of the relationship between autobiographical memory deficits and the self in AD has not been much investigated experimentally. In the present study, we aimed to investigate the integrative meaning of self-defining memories (SDMs) in early stages of AD and to analyse its relationship with the self-concept. The results showed that, when compared to the control group, AD patients less frequently extracted meaning from their SDMs and the meaning was less frequently tied to the self. Patients exhibited some altered aspects of the self-concept (i.e., complexity and strength), though some other components still persisted (i.e., valence and certainty). Correlation analyses showed that the impaired integrative meaning in the AD group was correlated with some changes in self-concept. We suggest that integrative meaning may act as a bridge between autobiographical memories and the self-concept, with reduced integration abilities appearing as a potential mechanism for the deterioration of the self-concept in AD.     

The orientation and temperature dependences of dislocation velocity in Ni 3 Al single crystals

The average velocities of screw dislocations in Ni 3 Al single crystals have been directly measured as a function of resolved shear stress (RSS) and orientation in the temperature domain of the flow stress anomaly using the etch-pit technique. The velocity was found to be extremely sensitive to the RSS in all cases. In contrast with ordinary metals, the screw dislocation velocities in Ni 3 Al show anomalous behaviour; under a constant RSS, the velocities decrease dramatically with increasing temperature. Furthermore, the velocities and the tension-compression asymmetry of the velocities depend on the orientation of applied stress.     

A Note Regarding the Validity of Lee's Typology of Love

In the present study, we investigated how well Lee's (1973/1976) typology of love characterized response data that adult subjects provided on selected items written by Hendrick and Hendrick. Results suggest that the model represents response data reasonably well and that Hendrick and Hendrick's (1986) measure ought to be valid.     

GAIA,OCKHAM'S RAZOR,THE SCIENCE OF COMPLEXITY

In this article, the author describes his sense of synchronicity with Edgar Morin's concepts of complexity. Although Morin only briefly addresses Gaia per se, the implications of Morin's work may reveal the Gaia concept as an element of the general breakthroughs of complexity science. Morin demonstrates a phase transition that is gaining momentum right now, whereby the new, more benign science is overwhelming the old Cartesian world.     

La naturaleza y medida de la ansiedad

RESUMEN

En este artículo se presenta una caracterización general de la naturaleza y medida de la ansiedad, a través de un enfoque factorial. Gracias a éste se consigue separar la ansiedad de dos cosas con las que se confunde constantemente: La reacción a la tensión y la inadaptación de la personalidad neurótica. Las medidas más precisas de la ansiedad que ahora son posibles aclaran también la relación entre la ansiedad y un factor tal como la inteligencia, y deben ayudar a contestar muchas preguntas similares sobre la relación entre la ansiedad y varias situaciones y actuaciones.     

On the archetypes in information systems development: An exploration

In this paper I examine possible archetypes that embody the role that systems analyst play in different models of systems development and briefly review attendant epistemological and ontological assumptions.     

Handedness and Hemispheric Asymmetry in the Control Of Movements

This study investigated the influence of hemispheric specialization of function on the motor performance of the hands. Right-handed (n=17), ambidextral (n=21), and ambisinistral (n=12) subjects performed Fitts' (1954) reciprocal tapping task under two conditions with each hand. Conditions had the same index of difficulty but differed in movement precision. The left hand of righthanders was superior in the condition requiring the greatest amount of preprogramming. Conversely, the right hand was not superior in the condition having the greatest demand for feedback control. For ambidextrals, left-hand superiority in the relatively preprogrammed condition was also revealed. Ambisinistrals showed no significant difference between conditions with either hand. The results partially support the hypothesis that the motor performance of the hands mirrors the dominant processing mode of their contralateral hemisphere. Failure to find supportive evidence in ambisinistrals is consistent with the contention that they lack hemispheric specialization of function.     

Bilateral Transfer as a Function of Mental Imagery

Three experiments are reported which investigate the role of mental imagery in the bilateral transfer from right to left hand of rotary pursuit skill. In Experiment 1 both mental imagery and physical rehearsal showed significant positive transfer relative to a control condition. However, work decrement may have accumulated and transferred in the physical rehearsal group thereby depressing this group’s left-hand performance. Experiment 2 was conducted under conditions designed to allow work decrement to dissipate prior to transfer to the contralateral limb. The data still showed no difference between physical re-hearsal and mental imagery. One interpretation of these data is that work decrement was present under both the physical rehearsal and mental imagery manipulations in Experiment 1. The data from Experiment 3 confirmed this interpretation as well as replicated the positive transfer effects found for mental imagery in Experiments 1 and 2. The data are discussed in terms of central versus peripheral explanatory mechanisms.     

Impaired finger dexterity in Parkinson's disease is associated with praxis function

A controversial concept suggests that impaired finger dexterity in Parkinson’s disease may be related to limb kinetic apraxia that is not explained by elemental motor deficits such as bradykinesia. To explore the nature of dexterous difficulties, the aim of the present study was to assess the relationship of finger dexterity with ideomotor praxis function and parkinsonian symptoms. Twenty-five patients with Parkinson’s disease participated in the study. Their left and right arms were tested independently. Testing was done in an OFF and ON state as defined by a modified version of the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS). Finger dexterity was assessed by a coin rotation (CR) task and ideomotor praxis using a novel test of upper limb apraxia (TULIA), in which the patients were requested to imitate and pantomime 48 meaningless, as well as communicative and tool-related gestures. Coin rotation significantly correlated with TULIA irrespective of the motor state and arm involved, but not with the MDS-UPDRS. This association was significantly influenced by Hoehn and Yahr stage.The strong association of finger dexterity with praxis function but not the parkinsonian symptoms indicates that impaired finger dexterity in Parkinson’s disease may be indeed apraxic in nature, yet, predominantly in advanced stages of the disease when cortical pathology is expected to develop. The findings are discussed within a cognitive-motor model of praxis function.