循环肿瘤细胞的研究进展

循环肿瘤细胞（circulating tumor cells,CTCs）指自发或因诊疗操作由实体瘤或转移灶释放进入外周血循环的肿瘤细胞。CTCs能被看作液体活检,具有实时监测功能,是一种非侵入性的新型诊断工具,有助于早期发现肿瘤的微转移,可评估预后,在治疗的监测及个体化治疗上具有重要的临床意义。     

A Typology of Youth Participation and Empowerment for Child and Adolescent Health Promotion

Research suggests that increasing egalitarian relations between young people and adults is optimal for healthy development; however, the empirical assessment of shared control in youth–adult partnerships is emerging, and the field still requires careful observation, identification, categorization and labeling. Thus, our objective is to offer a conceptual typology that identifies degrees of youth–adult participation while considering the development potential within each type. We use an empowerment framework, rooted in evidence-based findings, to identify five types of youth participation: (1) Vessel, (2) Symbolic, (3) Pluralistic, (4) Independent and (5) Autonomous. The typology is constructed as a heuristic device to provide researchers, practitioners and policy-makers with a common language for articulating degrees of youth participation for optimal child and adolescent health promotion.     

干细胞移植治疗缺血性心脏病研究的新途径:miRNAs

miRNAs在干细胞的自我更新、多向分化及分泌血管活性物质等过程中扮演作非常重要作用。近年来人们对于干细胞移植术治疗缺血性心脏病,取得了一定的成果,但仍然存在着大量有待解决的问题。例如如何增加移植后的干细胞存活率;改善梗死区的微环境,增加迁移或归巢到梗死区干细胞的数量等,而miRNAs在干细胞中的调节机制且表明miRNAs有可能成为干细胞移植研究的一个新的切入点。     

成人和婴儿麻疹临床特点和治疗

麻疹是一种急性呼吸道传染病,常见于6月～5岁儿童。近年来婴儿和成人麻疹患者在总患者数中所占比率表现出上升的趋势,容易造成误诊、漏诊。作为临床工作者,我们认为临床医生应充分认识到麻疹发病人群及年龄的改变,在临床工作中减少误诊,并为患者提供及时有效的治疗,对高危人群的有计划干预对于减低成人麻疹发病率有着重要作用。本文针对婴儿和成人麻疹的诊断和治疗进行了综述,试图提供参考。     

依恋——早期亲密关系的持续影响

依恋形成于婴幼时期,并贯穿人的一生。自从英国精神病学家J.Bowlby最早提出了依恋这一概念以来,依恋一直是发展心理学乃至整个心理学领域的研究重点,文章从不同理论学派对依恋如何形成所持的观点开始,从时间纬度分别介绍了"依恋"研究在幼儿期、青少年期以至成年期的主要理论以及与依恋行为有关的研究发现。     

光照的警觉性作用

光照除了传统的视觉作用外, 还具有一定的非视觉效应, 包括调节昼夜节律、褪黑素分泌和警觉性等生理功能和行为表现。随着光照对生理节律影响研究的不断深入, 近来很多学者开始关注光照的警觉性作用。我们根据最新研究进展总结了：(1)警觉性的测量工具; (2)光照强度、时长、时间点、波长、色温等对光照警觉性作用的影响; (3)光照在治疗情绪障碍、调节生理节律、完善办公照明方面的应用; (4)提出了继续探讨光照警觉性作用的神经机制、优化参数特征和探讨混淆变量的研究方向。     

MUSLIM PERSPECTIVES ON STEM CELL RESEARCH AND CLONING

In Islam, the acquisition of knowledge is a form of worship. But human achievement must be exercised in conformity with God's will. Warnings against feelings of superiority often are coupled with the command to remain within the confines of God's laws and limits. Because of the fear of arrogance and disregard of the balance created by God, any new knowledge or discovery must be applied with careful consideration to maintaining balance in the creation. Knowledge must be applied to ascertain equity and justice for all of humanity. Research in Islam must be linked to the broad ethical base set forth in the Qur'an and the Sunnah. Whether embryonic stem cell research or cloning is ethically acceptable in Islam depends on the benefits derived from such applications. What is most important for the scholars is to adhere to the concepts of compassion, mercy, and benefit to everyone.     

Proximity and distance goals in adult attachment

We used a variant of the Implicit Association Test (IAT) and explicit reports to examine the assumption that attachment anxiety and avoidance are related to proximity and distance goals. Results confirmed that attachment avoidance was associated with a stronger implicit motivation for and positive evaluation of distance goals in attachment relationships. This was found both at the implicit and explicit levels and both in a threat and non‐threat context. Attachment anxiety was associated with proximity goals only when measured explicitly, but not when goal activation was measured implicitly. Our findings highlight the importance of considering both implicit and explicit goal representations when studying motivational processes in the context of attachment, and suggest that the IAT can provide a useful tool for investigating implicit motivational constructs. Copyright © 2008 John Wiley & Sons, Ltd.     

老年人配偶支持的特点及其与夫妻依恋、婚姻满意度的关系

分别从实际和期望支持、情感和物质支持两个维度考察了老年人配偶支持的特点,并且采用结构方程模型来检验配偶支持、夫妻依恋和婚姻满意度三者之间的关系.289位有配偶的城市社区老年人参加了本次问卷调查,年龄范围为60～88岁.重要他人问卷、老年人夫妻依恋问卷及Locke-Wallace婚姻调适测定问卷分别用来测量老年人的配偶支持、夫妻依恋和婚姻满意度情况.结果表明:(1)性别、年龄及受教育水平不同的老年人在配偶支持上存在显著差异;(2)老年人的配偶支持与夫妻依恋和婚姻满意度三者两两相关,配偶支持以夫妻依恋为中介影响婚姻满意度.     

血管干细胞与血管性疾病

血管性疾病是目前严重威胁人类健康的疾病之一。血管干细胞的提出及其技术的应用对传统的治疗方式提出了巨大的挑战,开辟了新的思路。但同时也面临着一系列的技术和社会问题,有待进一步的探讨。