骨髓间充质干细胞移植治疗感音神经性聋的进展及评价

目前感音神经性聋缺乏直接有效的药物治疗措施,基因治疗及干细胞移植治疗为临床治疗提供新的思路。骨髓间充质干细胞具有异于其他干细胞的优点,耳蜗内移植后能起到基因治疗的目的,并有潜在的分化为内耳功能细胞的功能,但仍面临诸多尚待解决的问题。     

Maternal depression and dyadic interaction: the role of maternal attachment style

Maternal mental health and the contents of her representational world are important determinants of early parent–child relationship. We examined, first, the role of prenatal and postnatal depressive symptoms and maternal attachment style in predicting the quality of mother–child interaction. Second, we analysed whether the secure‐autonomous attachment style can protect the dyadic interaction from the negative effects of maternal depression. The participants were 59 mother–infant pairs examined during pregnancy (T1), 4–5 months postpartum (T2) and when the children were approximately 14 months old (T3). Maternal attachment style was assessed with a modified Adult Attachment Interview ‐procedure, depressive symptoms with Edinburgh Postnatal Depression Scale, and observed mother–child interaction with Care Index. The results show that autonomous mothers were more sensitive and responsive and their children more co‐operative than dyads with dismissing maternal attachment style. As hypothesized, mothers with the combination of both prenatal and postpartum depressive symptoms were highly unresponsive in their dyadic interaction. Further, prenatal depressive symptoms had a stronger impact on maternal unresponsiveness than postnatal symptoms. As hypothesized, mother's autonomous attachment style protected the mother–child interaction from the negative impact of maternal postnatal depressive symptoms, whereas dyads with preoccupied mothers were especially at risk for interaction problems when mothers had postpartum depressive symptoms. Copyright © 2010 John Wiley & Sons, Ltd.     

Brief report: Relativism and identity crisis in young adulthood

This study investigated the relationship between epistemological world views and identity formation. Forty college students, aged 17 to 23 years, were presented with a paradigm belief scale (Social Paradigm Belief Inventory; SPBI), an identity status questionnaire, and an indepth interview about a conflict they had recently experienced. It was hypothesized that a relativistic world view would be related to a moratorium identity status because relativistic thought processes involve a questioning of the objectivity of knowledge and authority structures and hence an awareness of the variety of alternative and potentially conflicting roles and choices. Results indicated that relativism was the most common world view used when responding to questions about a personal conflict and that relativistic scores on the SPBI were predictive of the moratorium status. Relativistic scores on the SPBI were also negatively related to identity achievement, as were mechanistic scores. Females experienced moratorium to a greater extent than males but were not more relativistic. Results are discussed in terms of linkages among cognitive development, psychosocial development, gender, and the type of measures used to assess world view status.     

Effort as Person-Focused Praise: “Hard Worker” Has Negative Effects for Adults After a Failure

Although work with children demonstrates a benefit of process-focused praise relative to person-focused praise on post-failure motivation, few studies have examined this result in adults. We tested the effect of three types of praise on adults' post-failure outcomes: person-focused intelligence (“high intelligence”), person-focused effort (“hard worker”), and process-focused effort (“worked hard”) in a sample of 156 adults recruited from Amazon's MTurk. Participants completed a set of easy visual pattern recognition problems and were told that they performed better than most adults and were given one of the three types of feedback. They then completed more difficult problems and were told that they had not performed well. Participants in the “hard worker” condition (compared to “worked hard”) were more likely to endorse intelligence as a reason for failure. They also reported lower perceived success and less enjoyment than participants in other conditions. Participants in the “high intelligence” condition were more likely to attribute their failure to intelligence than participants in the “worked hard” condition. The results suggest that the benefit of process-focused praise typically found in children (worked hard compared to intelligent) was mostly not replicated in adults, and person-focused effort praise was detrimental in a non-college student adult sample.     

Research Misconduct in the Age of Open Science: The Case of STAP Stem Cells

In early 2014, Dr Haruko Obokata and her co-authors caused a global media storm by publishing two scientific papers in Nature on stem cells. The papers proposed a surprisingly simple new method called stimulus-triggered acquisition of pluripotency (STAP) to generate pluripotent stem cells for research purposes in a fast and inexpensive way. To the dismay of many, both papers were retracted within six months of their release due to data fabrication and falsification. The rise and fall of the STAP research illustrates the impacts of open science practices of quality control and validation on new scientific claims. In the STAP case, collective action generated through two online forums—the Knoepfler Lab Stem Cell Blog and PubPeer—exposed not only data manipulation in the two papers but also the irreproducibility of the purported new cellular reprogramming method. The case brings to the fore the tentative possibilities as well as potential pitfalls of ‘accelerated virtual witnessing’ through crowdsourced post-publication peer reviews that value accessibility and inclusiveness. Indeed, it calls for empirically grounded discussion on the ongoing reconfiguration of the shared system of values and norms or the moral economy of science.     

A Comparison of Underage,Young, Middle,and Late Adults in Indicated Prevention Following Impaired Driving

The authors examined age differences in baseline features and program response in individuals completing indicated prevention (Prime For Life^®) for impaired driving. Risk perception, substance use, and support differed by age at baseline and, despite improvements, continued to differ postprogram.     

A Metastudy of Adultspan Journal: An Analysis of Publication Characteristics From 1999 to 2019

Articles published in Adultspan Journal from 1999 to 2019 were analyzed for trends over time in author characteristics (e.g., leading contributors and institutions, work setting, gender, domicile) and article characteristics (e.g., reporting standards, topics, research design, participant characteristics, and statistical sophistication).     

How impaired is too impaired? Exploring futile neuropsychological test patterns as a function of dementia severity and cognitive screening scores

Some older adults cannot meaningfully participate in the testing portion of a neuropsychological evaluation due to significant cognitive impairments. There are limited empirical data on this topic. Thus, the current study sought to provide an operational definition for a futile testing profile and examine cognitive severity status and cognitive screening scores as predictors of testing futility at both baseline and first follow-up evaluations. We analysed data from 9,263 older adults from the National Alzheimer’s Coordinating Center Uniform Data Set. Futile testing profiles occurred rarely at baseline (7.40%). There was a strong relationship between cognitive severity status and the prevalence of futile testing profiles, χ²(4) = 3559.77, p < .001. Over 90% of individuals with severe dementia were unable to participate meaningfully in testing. Severity range on the Montreal Cognitive Assessment (MoCA) also demonstrated a strong relationship with testing futility, χ²(3) = 3962.35, p < .001. The rate of futile testing profiles was similar at follow-up (7.90%). There was a strong association between baseline dementia severity and likelihood of demonstrating a futile testing profile at follow-up, χ²(4) = 1513.40, p < .001. Over 90% of individuals with severe dementia, who were initially able to participate meaningfully testing, no longer could at follow-up. Similarly, there was a strong relationship between baseline MoCA score band and likelihood of demonstrating a futile testing profile at follow-up, χ²(3) = 1627.37, p < .001. Results can help to guide decisions about optimizing use of limited neuropsychological assessment resources.